l-Carnitine in the treatment of painful diabetic neuropathy and its effect on plasma β-endorphin levels

Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis

“…After excluding 218 articles based on title/abstract review (predominantly because they did not include participants with diabetic neuropathy), 12 articles were retrieved for full text review. Finally, six articles [22][23][24][25][26][27] were included in the qualitative synthesis and five [23][24][25][26][27] were included in the quantitative analysis. Of the included articles, three were RCTs [23][24][25] (Figure 1).…”

“…The other three descriptive studies [22,26,27] reporting data regarding the effect of LC on diabetic neuropathy are described in the Supplementary Table 2. All three descriptive studies were conducted in Turkey and involved 53 people with type 1 and/or 2 diabetes.…”

“…All studies (except one [22]) reported the effect of ALC/LC on EMG parameters. We were able to meta-analyze pre and post-test changes from 4 of the 5 studies reporting data on EMG parameters.…”

Beta-endorphin levels in both painful and painless diabetic peripheral neuropathy and its relations to pain characters and severity

“…Cakir et al, conducted a study on 7 diabetic patients with painful DN, 7 diabetic patients without DN, and 7 healthy control subjects to investigate the efficacy of L-carnitine (LC) in the treatment of painful diabetic neuropathy (DN) and its effects on levels of the endogenous peptide b-endorphin. They found no difference in basal b-endorphin levels between diabetic patients with painful DN and diabetic patients without neuropathy and they also spotted that basal b endorphin levels were significantly lower in the diabetic patients in comparison to the control group [30]. Tsigos et al, reported that b-endorphin concentrations are reduced in the CSF of patients with sensory diabetic polyneuropathy.…”

Supplementation with carnitine for weight loss: a biochemical approach

“…Supplementation with carnitine. It has been scientifically recognized that carnitine can be supplemented to improve some clinical conditions like anorexia 23 ; cardiovascular disease, angina and ischemia 24 ; cardiogenic shock 25 ; cardiomyopathy 26,27 ; myocardial infarction 28 ; hyperlipidemia 29 ; insulin resistance 30 ; painful diabetic neuropathy 31 ; chronic fatigue syndrome 32 ; fatty liver 33 ; hepatitis and hepatic encephalopathy 34 ; immunity problems 35 ; hyperthyroidism 36 ; male infertility 37 ; renal failure/dialysis 38,39 ; respiratory distress in premature infants 40 , and inherited inborn errors of fatty-acid oxidation 41 .…”