L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: Different participation of NO and COX-products

Bueno, Rosario; Sotomayor, Marı́a Álvarez de; Pérez‐Guerrero, Concepción; Gómez-Amores, Lucía; Vázquez, Carmen M.; Herrera, Marcelino

doi:10.1016/j.lfs.2005.01.035

Cited by 54 publications

(58 citation statements)

References 33 publications

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“…Furthermore, we have recently reported that both compounds improved endothelial dysfunction in aortic rings from spontaneously hypertensive rats (SHR) by increasing NO participation in endothelium-dependent relaxations. In addition to the NO-related effect, LC increased prostacyclin production in this animal model [3]. …”

Section: Introductionmentioning

confidence: 99%

Effect of L-Carnitine and Propionyl-L-Carnitine on Endothelial Function of Small Mesenteric Arteries from SHR

et al. 2007

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Background:The effect of treatment with either 200 mg·kg^–1 of L-carnitine (LC) or propionyl-L-carnitine (PLC) was studied on endothelial dysfunction of small mesenteric arteries (SMA) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Methods: Systolic blood pressure (SBP) was measured and endothelial and vascular functions were assessed by the effect of carbachol (CCh) and phenylephrine (Phe). O₂^– produced by SMA and eNOS expression were evaluated by chemiluminescence and Western blot, respectively. Results: Although SBP was not affected, endothelial relaxation increased in both LC- and PLC-treated SHR. Nevertheless, the CCh-induced contraction remained sensitive to indomethacin in these rats. On the contrary, NO participation was increased in all the groups except for LC-treated WKY. Furthermore, high concentrations of Phe produced NO-dependent relaxation of SMA from PLC-treated rats. Both compounds decreased basal and NADPH-stimulated O₂^– in SHR toward values observed in WKY. Only PLC increased eNOS protein expression in SHR. Neither LC nor PLC affected endothelium-derived hyperpolarizing factor-induced relaxation. Conclusions: LC and its propionate improved endothelial responses of SMA from SHR by decreasing O₂^– production and thus increasing NO availability. PLC also increased NO synthesis by enhancing eNOS expression.

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Section: Introductionmentioning

confidence: 99%

Effect of L-Carnitine and Propionyl-L-Carnitine on Endothelial Function of Small Mesenteric Arteries from SHR

et al. 2007

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“…10 Several studies mentioned that carnitine can induce vasodilatation of subcutaneous arteries involving endothelium through the effect related to the synthesis of prostoglandines. 11,12 Carnitin treatment were applied in various methods such as subcutaneous, intraperi-toneal and subcutaneous + intraperitoneal in this study in order to compare the results of each group. It was observed that the carnitine injected groups (group III-VII) were significantly better in skin necrosis development and progression compared to control group (p<0.001).…”

Section: Resultsmentioning

confidence: 99%

“…10 Recent studies also revealed that carnitine can induce vasodilatation of subcutaneous human arteries involving the endothelium through the effect related to the synthesis of PGs, especially PGI2. 11,12 In this study, the authors aimed to investigate the effect of carnitine on doxorubicin induced extravasation, therefore an experimental study was designed.…”

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The Effect of Carnitine on Doxorubicin Induced Extravasation Injuries: A New Treatment Method for Extravasation Injuries

Menderes¹,

Nazlioglu²,

Ersen³

et al. 2017

World Clin J Med Sci

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“…Hipertansif ve normotansif ratlarda 8 hafta boyunca verilen (200 mg/kg/gün) L-karnitinin endotel disfonksiyonu üze-rindeki etkilerinin araştırıldığı bir çalışmada, her iki grupta da L-karnitin tedavisi ile prostaglandin-2 (PG-2) ve nitrik oksit (NO) yapımının arttığı gözlenmiştir. Çalışmanın bitiminde hipertansif ratlarda L-karnitinin reaktif oksijen ürünlerini düşürebileceği ve nitrik oksit yapımını arttırabileceği ve böylelikle endotel bağımlı relaksasyona katkıda bulunabileceği sonucuna varılmıştır (36). Ayrıca Henera ve ark.…”

Section: Discussionunclassified

Low L-carnitine levels: Can it be a cause of nocturnal blood pressure changes in patients with type 2 diabetes mellitus?

Korkmaz¹,

Yıldız²,

Kilicli³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Tip 2 diyabetes mellituslu (tip 2 DM) hastalarda noktürnal kan basıncındaki (NKB) düşüş normalden daha azdır. L-karnitin eksikliği tip 2 DM olgularında hiperglisemi, insülin direnci ve endotel disfonksiyonuna yol açarak NKB değişikliklerine neden olabilmektedir. Bu çalışmada; tip 2 DM'li "dipper" ve "non-dipper" olgularda L-karnitin düzeyinde farklılık olup olmadığının araştırılması amaçlanmıştır. Yöntemler: Bu bir enine-kesitli gözlemsel kohort çalışmasıdır. Çalışmada tip 2 DM'li 50 (33 kadın, 17 erkek) olguyu ve kontrol grubu olarak sağ-lıklı 35 (18 kadın, 17 erkek) kişiyi karşılaştırdık. Tüm olgularda ambulatuvar kan basıncı izlemi (ABPM) yapıldı ve L-karnitin ölçüldü. Verilerin değerlendirilmesinde iki ortalama arasındaki farkın önemlilik testi, Ki-kare testi, Mann-Whitney U testi ve Pearson korelasyon analizi kullanıldı. Bulgular: Tip 2 DM'lerin %72'sinde "non-dipper" örnek saptadık. Tip 2 DM'lerde L-karnitin düzeyi (52.77±12.34 μmol/L) kontrol grubuna göre (79.18±10.59 μmol/L) istatistiksel olarak anlamlı derecede düşük saptandı (p<0.05). "Non-dipper" olgularda L-karnitin düzeyleri (50.02±16.30 μmol/L) "dipper" olgulara (53.83±10.50 μmol/L) göre daha düşüktü, ancak bu farklılık anlamlı değildi (p=0.125). Sonuç: Tip 2 DM' lu hastalarda "non-dipper" örnek sık görülmektedir. "Non-dipper" örnek hedef organ hasarı ile ilişkilidir. Bu yüzden ABPM ile saptanacak olan "non-dipper" örnek çok önemlidir. Hasta grubunda L-karnitin düzeyleri düşük saptanmıştır. Tip 2 DM'li "non-dipper" olgularda L-karnitin, "dipper" olgulara göre daha düşük saptanmıştır. Bu farklılık istatistiksel olarak anlamlı olmamakla birlikte, tip 2 DM'li olgularda "nondipper" sıklığı ve L-karnitin ile ilişkisini araştıracak daha geniş ölçekli ve detaylı araştırmalara gereksinim olduğu sonucuna varılmıştır. (Anadolu Kardiyol Derg 2011 1: 57-63) Anahtar kelimeler: Tip 2 diyabetes mellitus, L-karnitin, noktürnal kan basıncı, "non-dipper" örnek ABSTRACT Objective: The nocturnal blood pressure (NBP) reduction is less than normal in the patients with type 2 diabetes mellitus (type 2 DM). L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM. The purpose of the study was to investigate whether there is a difference in levels of L-carnitine in dipper and nondippers patients with type 2 DM. Methods: This is a cross-sectional observational cohort study. We compared the 50 (33 females, 17 males) patients with type 2 DM and the 35 healthy persons (18 females, 17 males) as a control group. In all cases, ambulatory blood pressure monitoring (ABPM) was performed and L-carnitine was measured. The independent samples t test, Chi-square test, Mann-Whitney U test and Pearson correlation analysis were used in the statistical evaluation of data. Results: We found that the percentage of nondipper pattern was 72% in patients with type 2 DM. L-carnitine levels were lower in patients with type 2 DM (52.77±12.34 μmol/L) than those of control group (79.18±10.59 μmol/L...

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L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: Different participation of NO and COX-products

Cited by 54 publications

References 33 publications

Effect of <i>L</i>-Carnitine and Propionyl-<i>L</i>-Carnitine on Endothelial Function of Small Mesenteric Arteries from SHR

Effect of <i>L</i>-Carnitine and Propionyl-<i>L</i>-Carnitine on Endothelial Function of Small Mesenteric Arteries from SHR

The Effect of Carnitine on Doxorubicin Induced Extravasation Injuries: A New Treatment Method for Extravasation Injuries

Low L-carnitine levels: Can it be a cause of nocturnal blood pressure changes in patients with type 2 diabetes mellitus?

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