L-carnitine and acetyl-L-carnitine status during hemodialysis with acetate in humans: a kinetic analysis

Jackson, J M; Lee, H A

doi:10.1093/ajcn/64.6.922

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…The acylcarnitine to total carnitine ratio was 0.30±0.02, indicating a redistribution of the plasma carnitine pool towards acylcarnitines [5]. Acylcarnitines were represented mainly by acetylcarnitine, as reported in other studies [6,7,14]. Interestingly, propionylcarnitine could be detected in five patients with plasma concentrations ranging between 0.52 and 0.81 mmol/l.…”

Section: Discussionsupporting

confidence: 68%

“…In several studies, the metabolism of carnitine in patients on long-term haemodialysis has been investigated. Most of them were restricted to the observation of free and acylcarnitines [12,13], but in some studies the individual acylcarnitines were differentiated [6,14]. In one recent study, the plasma concentration of carnitine, acetylcarnitine and total carnitine was investigated in patients on haemodialysis before and after intravenous supplementation of different doses of carnitine [6].…”

Section: Introductionmentioning

confidence: 99%

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Effect of L-carnitine on the kinetics of carnitine, acylcarnitines and butyrobetaine in long-term haemodialysis

Vernez¹,

Dickenmann²,

Steiger³

et al. 2006

Nephrology Dialysis Transplantation

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Background. The current study was performed to investigate the kinetics of carnitine, individual acylcarnitines and butyrobetaine in patients on haemodialysis. Methods. Eight stable long-term haemodialysis patients were studied under basal conditions (no carnitine supplementation) and 3 weeks after intravenous supplementation with L-carnitine (10 or 20 mg/kg body weight) after each haemodialysis session. The kinetic studies included serial determinations of carnitine and metabolites just before, during or between haemodialysis sessions. Analysis was performed by liquid chromatography-tandem mass spectrometry. Results. Before haemodialysis, the plasma concentrations were (mmol/l) 15.1±0.6 (mean±SEM) for carnitine, 5.9±0.7 for acetylcarnitine, 0.66±0.04 for propionylcarnitine and 0.98±0.08 for butyrobetaine (basal conditions) or 142±23 for carnitine, 69±12 for acetylcarnitine, 6.0±1.1 for propionylcarnitine and 2.6±0.3 for butyrobetaine (carnitine 20 mg/kg). During haemodialysis, the plasma concentrations dropped by $80% for all compounds determined, with extraction coefficients ranging from 0.65 to 0.86. In patients supplemented with 20 mg/kg carnitine, the amount of carnitine removed by haemodialysis equalled 42% of the dose administered, consisting of 2.08 mmol carnitine, 1.03 mmol acetylcarnitine and 0.051 mmol propionylcarnitine. Between the haemodialysis sessions, carnitine, acylcarnitines and butyrobetaine reached apparent steady-state concentrations within 1 day both under basal conditions and after supplementation. Conclusions. Patients on haemodialysis have reduced carnitine, acylcarnitine and butyrobetaine plasma levels, which can be increased by supplementing carnitine. Propionylcarnitine, an important constituent of the acylcarnitine pool, can be removed by haemodialysis. Removal of potentially toxic acyl-groups may represent a mechanism for a beneficial effect of carnitine in these patients.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Effect of L-carnitine on the kinetics of carnitine, acylcarnitines and butyrobetaine in long-term haemodialysis

Vernez¹,

Dickenmann²,

Steiger³

et al. 2006

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

show abstract

“…Correspondingly, skeletal muscle-free LC in hemodialysis patients may decrease (9,10). Because gut absorption of carnitine is unimpaired (11), reversal of this deficiency by oral supplementation is biologically plausible and reasonable.…”

mentioning

confidence: 99%