Effect of hemodialysis session on the dynamics of carnitine ester profile changes in l-carnitine pretreated end-stage renal disease patients

Csiky, Botond; Bene, Judit; Wittmann, István; Sulyok, E.; Melegh, Béla

doi:10.1007/s11255-012-0209-x

Cited by 9 publications

(6 citation statements)

References 38 publications

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“…Next, we calculated the removal rate of long‐chain acylcarnitine, adjusting for total protein levels before and after dialysis. We found that, similarly to previous reports, the removal rate of long‐chain acylcarnitine was lower than that of short‐chain or medium‐chain acylcarnitines, The reason for this is considered to be because long‐chain acylcarnitines have greater molecular weight and lipophilicity. However, in all patients in the present study, haemodialysis or haemodiafiltration using a high performance membrane with high β2MG (molecular weight: 11800) clearance was used.…”

Section: Discussionsupporting

confidence: 88%

Association between resistance to erythropoiesis‐stimulating agents and carnitine profile in patients on maintenance haemodialysis

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Association between resistance to erythropoiesis‐stimulating agents and carnitine profile in patients on maintenance haemodialysis

et al. 2018

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“…5 We found that Fc and Tc levels in non-medicated patients undergoing HD were lower than those in the control group. Patients may have low Tc and Fc levels due to lower protein and meat intake, which results in lower carnitine intake; less absorption by the gastrointestinal tract; reduced carnitine synthesis in the kidneys; low renal tubular reabsorption; carnitine transport disorder; and the fact that it is highly dialyzable because of its low molecular weight and lack of protein binding in the plasma.…”

Section: Discussionmentioning

confidence: 61%

Clinical significance of different carnitine levels for improving the prognosis of patients undergoing hemodialysis

Zhang

et al. 2016

Renal Failure

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Objective: To investigate plasma-free carnitine (Fc), acylcarnitine (Ac), and total carnitine (Tc) levels in patients undergoing hemodialysis (HD), and to explore their clinical significance. Methods: A total of 20 subjects were in the normal control group and 133 patients undergoing HD were divided into medicated (received carnitine treatment) and non-medicated groups. The medicated group was further divided into three subgroups according to Fc level: , and ! 300 lmol/L. We used non-derivative tandem mass spectrometry to determine carnitine levels, and clinical symptoms such as weakness, hypotension, and muscle cramps were recorded during dialysis. Results: Fc and Tc levels were significantly lower in the non-medicated group than in the control group, whereas Fc, Ac, and Tc levels were higher in the medicated than non-medicated group (p< .05). The medicated group had fewer symptoms during dialysis than the non-medicated group such as weakness, hypotension, and muscle cramps (p< .05). An additional comparison showed that the incidence rates of hypotension and muscle cramps in the Fc < 80-199 lmol/L group were significantly lower than those in the Fc ! 300 lmol/L medicated and non-medicated groups. Conclusions: Patients undergoing HD have low carnitine levels. L-Carnitine can effectively increase Fc concentration and improve clinical symptoms; however, only the proper Fc range can reduce complications caused by dialysis. Thus, this range needs to be determined. ARTICLE HISTORY

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“…Therefore, the potential role of uridine 5-diphosphate in the inflammatory response is likely to be related to the involvement of chemokines in inflammation. The depletion of carnitine was previously reported to be prevalent in hemodialysis patients, which was assumed to be associated with their inflammatory response in patients [36]. Moreover, exogenous carnitine was required to satisfy energy consumption, which might reflect on carnitine's indirect modulation of the inflammatory response by regulating energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses

Gong

et al. 2020

J Neuroinflammation

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Background: Inflammation is a general pathological phenomenon during severe disturbances to the homeostasis. Forsythiaside A (FA) and forsythiaside B (FB), isolated from the dried fruit of Forsythia suspensa (Thunb.) Vahl, are phenylethanoid compounds that show a significant anti-inflammatory effect. However, the properties and therapeutic mechanisms of this effect have not yet been systematically elucidated. Methods: In this study, the anti-inflammatory effects of FA and FB were investigated in CuSO 4-induced inflammation in zebrafish larvae. Intracellular generation of reactive oxygen species (ROS) and nitric oxide (NO) was investigated using fluorescence probes. Metabolomic and proteomic analyses using liquid chromatography-mass spectrometry were carried out to identify the expressions of metabolites and proteins associated with the anti-inflammatory mechanism of FA and FB. Quantitative polymerase chain reaction (PCR) was performed to detect the progressive changes in gene expression. Results: FA and FB inhibited neutrophils migration to the damaged neuromasts and remarkably reduced CuSO 4induced ROS and NO generation in zebrafish larvae. Metabolomic analysis pointed to the involvement of nicotinate and nicotinamide metabolism, energy metabolism, pyrimidine metabolism, and purine metabolism. Proteomic analysis identified 146 differentially expressed proteins between the control and model groups. These included collagen [collagen type II alpha 1b precursor (col2a1b), collagen alpha-2(IX) chain precursor (col9a2), collagen type IX alpha I precursor (col9a1b)], nucleoside diphosphate kinase 3 isoform X1 (Nme3), WD repeat-containing protein 3 (Wdr3), and 28S ribosomal protein S7 mitochondrial precursor (Mrps7). FA and FB were shown to reverse the abnormal expressions of potential metabolite and protein biomarkers and alleviate CuSO 4-induced damage to the neuromasts in the zebrafish lateral line.

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Effect of hemodialysis session on the dynamics of carnitine ester profile changes in l-carnitine pretreated end-stage renal disease patients

Abstract: The washout induced by HD session results in variable depletion of short-, medium-, and long-chain carnitine esters in carnitine-pretreated patients; the recovery of the circulating carnitine esters from the body stores occurs within 30 min after the cessation of the HD procedure.

Cited by 9 publications

References 38 publications

Association between resistance to erythropoiesis‐stimulating agents and carnitine profile in patients on maintenance haemodialysis

Association between resistance to erythropoiesis‐stimulating agents and carnitine profile in patients on maintenance haemodialysis

Clinical significance of different carnitine levels for improving the prognosis of patients undergoing hemodialysis

Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses

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