L’asthme professionnel en Alsace : quelques particularités régionales

Popin, E; Kopferschmitt-Kubler, M.C.; González, Miguel A.; Brom, M.; Flesch, F.; Pauli, G.

doi:10.1016/s0761-8425(08)74345-6

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…Healthcare professions are ranked second in OA diagnosed in Alsace. Domestic cofactors, a particular predisposition notably as regards irritants found in the healthcare sector and cleaning occupations, might be evoked so as to explain such over representation of women with regard to occupational asthma in this region [26]. More than the half (57.6%) of recognized OA cases worked in the textile industry.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Occupational Asthma in Tunisia: Results of a First National Study

Maoua¹,

Olfa²,

Boughattas³

et al. 2016

ODEM

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Introduction: Apart from its increasingly important frequency, occupational asthma (OA) has become the most important cause of occupational respiratory disorders in developed countries. The number of etiological agents continues to grow following the constant introduction of new harmful substances in industry. Objectives: Determine the prevalence and incidence of OA in our country, the socio-occupational characteristics of asthmatics, and study the forensic and social impact of such pathology. Material and Methods: An exhaustive retrospective epidemiological study was conducted in Tunisia about charts of occupational asthma cases recognized by the competent commissions of the National Medical Care Fund (CNAM) during the period ranging from January 1 st 2000 to December 31 st 2008. Results: 361 occupational asthma cases, accounting for a prevalence of 7.17% of all occupational diseases, were recognized during the period of the study. Occupational asthma annual incidence was estimated to be 24.42 cases per 1000000 workers. Our study population was mainly women with a sex ratio of 0.86. More than a half (57.6%) of recognized OA cases were working in the textile industry sector. Concerning the asthmatics' professional career, most of recognized OA cases (n = 225 i.e. 70.6% of cases) kept their jobs, whereas 58 patients did not. The professional career was linked to gender with a job loss that is 1.79 time more important in asthmatic women. Conclusion: The incidence of occupational asthma in Tunisia is comparable * Corresponding author.M. Maher et al. 28with that found in other Mediterranean countries. A rigorous and adequate prevention is necessary and allows reducing the importance of this occupational pathology and its serious consequences.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Occupational Asthma in Tunisia: Results of a First National Study

Maoua¹,

Olfa²,

Boughattas³

et al. 2016

ODEM

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Evaluation of Quantification Methods to Compensate for Matrix Effects in the Analysis of Benzalkonium Chloride and Didecyldimethylammonium Chloride in Fruits and Vegetables by LC-ESI-MS/MS

Diez

Feinberg²,

Spörri

et al. 2015

Food Anal. Methods

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Given the extensive presence of some toxic quaternary ammonium compound residues in foodstuffs arriving into the EU during 2012, the Food Authority Control of Geneva decided to implement a monitoring plan to investigate the presence of these contaminants in food: a method based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction and liquid chromatography electrospray tandem mass spectrometry was developed for analyzing didecyldimethylammonium chloride and four benzalkonium chloride homologue residues in fruits and vegetables. An in-house method validation, based on the SANCO guidelines (Document SANCO No. 12571/2013), was conducted using three independent series in orange, lettuce, and avocado composite samples spiked at three levels (10, 100, 500 μg/kg). Trueness and precision were calculated by pooling all results at each concentration level to account for the variability among fruits and vegetables. To avoidmatrix effects on quantitative results, five quantification strategies were investigated: (i)solvent calibration, (ii) matrix-matched calibration prepared on samples and (iii) on sample extract aliquots, and (iv) standard addition prepared on samples and (v) on sample extract aliquots. Due to the nonlinear instrumental response for the large concentration range investigated, a quadratic calibration model was mandatory for all approaches. Solvent calibration gave very poor recoveries due to the high signal suppression caused by matrix effects. Smaller biases were observed for matrix-matched calibrations; however, these results exhibited relatively low precision. Both of the standard addition methods compensated for matrix effects and provided accurate analytical results. Due to the ease of its implementation, the matrix standard addition method, where analytes are added to sample extract aliquots, was preferred over the classical standard addition in samples. Nonlinear extrapolations appeared to be particularly effective in obtaining good results for both standard addition methods when the calibration curve was convex or very slightly concave. The resulting validated method was used to monitor 108 fruit and vegetable commercial samples in May 2013

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