l-arginine protects against T-2 toxin-induced male reproductive impairments in mice

Zhang, Yong Fa; Yang, Jian Ying; Meng, Xiang Ping; Xiao, Qiao

doi:10.1016/j.theriogenology.2018.12.024

Cited by 17 publications

(11 citation statements)

References 38 publications

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“…Pretreatment with l -arginine supplementation in the mouse diets significantly improved semen quality, DSP, and the serum T content in mice exposed to T-2 toxin. In addition, l -arginine can mitigate the decreased pregnancy rate and increased fetal resorption rate in females that are mated with male mice exposed to T-2 toxin . Taken together, these studies indicate that l -arginine supplementation has a mitigation effect on male reproductive toxicity resulting from T-2 toxin exposure.…”

Section: Detoxification Of the Reproductive Toxicity Of T-2 Toxinmentioning

confidence: 68%

“…In addition, L-arginine can mitigate the decreased pregnancy rate and increased fetal resorption rate in females that are mated with male mice exposed to T-2 toxin. 82 Taken together, these studies indicate that L-arginine supplementation has a mitigation effect on male reproductive toxicity resulting from T-2 toxin exposure.…”

Section: Detoxification Of the Reproductive Toxicity Of T-2 Toxinmentioning

confidence: 79%

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Review of the Reproductive Toxicity of T-2 Toxin

Yang

Liu

Cui

et al. 2020

J. Agric. Food Chem.

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T-2 toxin, an inevitable environmental pollutant, is the most toxic type A trichothecene mycotoxin. Reproductive disruption is a key adverse effect of T-2 toxin. Herein, this paper reviews the reproductive toxicity of T-2 toxin and its mechanisms in male and female members of different species. The reproductive toxicity of T-2 toxin is evidenced by decreased fertility, disrupted structures and functions of reproductive organs, and loss of gametogenesis in males and females. T-2 toxin disrupts the reproductive endocrine axis and inhibits reproductive hormone synthesis. Furthermore, exposure to T-2 toxin during pregnancy results in embryotoxicity and the abnormal development of offspring. We also summarize the research progress in counteracting the reproductive toxicity of T-2 toxin. This review provides information toward a comprehensive understanding of the reproductive toxicity mechanisms of T-2 toxin.

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Section: Detoxification Of the Reproductive Toxicity Of T-2 Toxinmentioning

confidence: 68%

Section: Detoxification Of the Reproductive Toxicity Of T-2 Toxinmentioning

confidence: 79%

Review of the Reproductive Toxicity of T-2 Toxin

Yang

Liu

Cui

et al. 2020

J. Agric. Food Chem.

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“…Therefore, they reported that L-arginine and resistance training has a synergistic effect on testosterone. Additional studies have reported the effects of L-arginine in reducing testicular toxicity and suppressing the decrease in testosterone [40][41][42].…”

Section: L-argininementioning

confidence: 99%

A Review of foods and food supplements increasing testosterone levels

Kataoka¹,

Hotta²,

Kimura³

2021

JOMH

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Androgens are essential for male physical activity. Age-related androgen deﬁciency, known as late-onset hypogonadism (LOH), is considered a risk factor for several diseases. There are many men's health supplements on the market. Therefore, the purpose of this review is to summarize the food ingredients that have been suggested in published literature to increase testosterone levels. A review of previously reported animal studies suggested that 5 representative nutritional components, 7 food ingredients, and 25 supplements were associated with testosterone. Some food and supplements inﬂuence testosterone levels in various animals by directly increasing testosterone or suppressing the decrease in testosterone production due to testicular toxicity. There are three mechanisms by which foods or supplements increase testosterone production: 1) regulating luteinizing hormone, the hormone that stimulates testosterone production, 2) regulating testosterone synthase in the testis, and 3) regulating testosterone-degrading enzymes. In contrast, suppressing the decrease in testosterone depends on the antioxidant effect of the foods. Although detailed mechanistic studies and clinical trials are required to validate these ﬁndings, the use of food to regulate testosterone levels is a promising therapeutic option.

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“…However, the combined toxic mechanism of T-2 and its main metabolites HT-2 and NEO in porcine LCs has been unclear. As a consequence of T-2 toxin treatment, the DNA damage in the LCs is caused by the oxidative stress pathway, and eventually leads to apoptosis and high autophagy and presented a series of toxic effects [18][19][20][21]. In addition, HT-2 and NEO, as metabolites of T-2, usually have similar toxicity characteristics [22,23].…”

Section: Introductionmentioning

confidence: 99%

Potential Role of Individual and Combined Effects of T-2 Toxin, HT-2 Toxin and Neosolaniol on the Apoptosis of Porcine Leydig Cells

Zhao

Guo

et al. 2022

Toxins

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T-2 toxin usually co-occurs with HT-2 toxin and neosolaniol (NEO) in the grains and feed. Our previous studies found that T-2 toxin and its metabolites’ binary or ternary combination exposure to porcine Leydig cells (LCs) displayed synergism in certain range of dosage and cannot be predicted based on individual toxicity. However, the possible mechanism of these mycotoxins’ combined exposure to cell lesions remains unknown. Based on 50% cell viability, the mechanism of apoptosis in porcine Leydig cells was investigated after exposure to T-2, HT-2, NEO individual and binary or ternary combinations. Compared with control, the adenosine triphosphate (ATP) content decreased, reactive oxygen species (ROS) level increased, and mitochondrial membrane potential (MMP) decreased in all treated groups. Additionally, the cell apoptosis rates were significantly increased in test groups (p < 0.05), and the B-cell lymphoma 2 (Bcl-2) Associated X (Bax)/Bcl-2 ratio and the expression of caspase 3, caspase 8, cytochrome c (Cytc) in the treated group are all significantly higher than the control group. Moreover, the expression of Cytc and caspase 8 gene in NEO and T-2+NEO groups was significantly higher than that in other individual and combined groups. It can be concluded that the toxicities of T-2, HT-2, and NEO individually and in combination can induce apoptosis related to the oxidative stress and mitochondrial damage, and the synergistic effect between toxins may be greater than a single toxin effect, which is beneficial for assessing the possible risk of the co-occurrences in foodstuffs to human and animal health.

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l-arginine protects against T-2 toxin-induced male reproductive impairments in mice

Cited by 17 publications

References 38 publications

Review of the Reproductive Toxicity of T-2 Toxin

Review of the Reproductive Toxicity of T-2 Toxin

A Review of foods and food supplements increasing testosterone levels

Potential Role of Individual and Combined Effects of T-2 Toxin, HT-2 Toxin and Neosolaniol on the Apoptosis of Porcine Leydig Cells

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