Review of the Reproductive Toxicity of T-2 Toxin

Yang, Xu; Liu, Pengli; Cui, Yilong; Xiao, Bonan; Liu, Meilin; Song, Miao; Huang, Wanyue; Li, Yanfei

doi:10.1021/acs.jafc.9b07880

Cited by 63 publications

(29 citation statements)

References 76 publications

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Section: Mechanisms Of Oxidative Stress Induction By Environmental Pollutantsmentioning

confidence: 99%

“…The T-2 toxin is another major Fusarium mycotoxin contaminating crops [ 123 ]. In pregnant animals, the T-2 toxin induces placental lesions, embryotoxicity and abnormal development of offspring [ 123 , 124 ]. It has been shown that the T-2 toxin induces OS in placenta; however, its precise mode of action remains to be explored [ 125 ].…”

Section: Mechanisms Of Oxidative Stress Induction By Environmental Pollutantsmentioning

confidence: 99%

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The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

2022

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Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.

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Section: Mechanisms Of Oxidative Stress Induction By Environmental Pollutantsmentioning

confidence: 99%

Section: Mechanisms Of Oxidative Stress Induction By Environmental Pollutantsmentioning

confidence: 99%

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

2022

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“…T-2 is the most toxic type A trichothecene mycotoxin, it is an environmental contaminant. A new report shows that reproductive disruption is a key adverse effect of T-2 toxin (Yang et al, 2020). Therefore, detection of T-2 indicated the relatively high health risk of Fusarium contamination in dried fish.…”

Section: Mycotoxin Contamination In Dried Fishmentioning

confidence: 99%

Fungal diversity and mycotoxin contamination in dried fish products in Zhanjiang market, China

et al. 2021

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Dried fish are important dietary protein and income sources in Zhanjiang, China. Mycotoxins produced by pathogenic fungi that contaminate fish during processing can cause considerable hazard to consumer health. This study reports fungal diversity, total fungal counts and mycotoxin contamination of dried fish sold at the seafood market in Zhanjiang. Seven dried fish products (Hemibarbus maculatus, Pseudosciaena crocea, Lutjanus erythopterus, Thunnus thynnus, Scomberomorus niphonius, Eleutheronema tetradactylum, Trichiurus lepturus, n = 10) from seven retailers were analyzed for contaminated fungal species, occurrence frequency and residues analysis of four mycotoxins. Using potato dextrose agar (PDA) plate purification, morphology observation, internal transcribed spacer (ITS) sequence analysis, 25 fungal strains representing 12 genera from dried fish were systematically isolated and identified. Three dominant genera in dried fish were Fusarium sp. (80.4%), Penicillium sp. (70.7%) and Aspergillus sp.(63.9%). Other fungal genera were Neoscytalidium sp.(38.1%), Cutaneotrichosporon sp. (38.1%), Trichoderma sp.(20.3%), Naganishia sp.(15.3%), Kodamaea sp. (10.8%), Phialemoniopsis sp.(9.2%), Nigrospora sp.(7.3%), Ceriporia sp.(6.3%), Phellinus sp.(4.5%). Aspergillus flavus contamination was the higher and ranged from 1.10 × 10 3 to 2.40 × 10 4 cfu/g. The mean fungal contamination of other fungal species in dried fish ranged from 1.07 × 10 2 to 4.58 × 10 4 cfu/g. The total fungal counts of Fusarium sp. ranged from 1.09 × 10 2 to 2.11 × 10 4 cfu/g, but the occurrence frequency is relatively high. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses showed that mycotoxin residues were present in 12 out of the 25 dried fish tested. Aflatoxin B 1 (AFB 1) was the most frequently detected and the concentration ranged from 0.03 to 3.52 μg/kg. T-2 toxin (T-2), ochratoxin A (OTA), and deoxynivalenol (DON) concentrations ranged from 0.21 to 1.53, 0.03-2.21 and 0.71 μg/kg respectively. High occurrence of fungal populations and mycotoxins in dried fish sold in the Zhanjiang market pose a potential threat to consumer health. It is recommended that in future, advanced processing methods and controlled storage condition need to be used to minimize and if possible eliminate fungal contamination during dried fish processing.

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“…1 T-2 toxin is one of the most toxic trichothecene mycotoxins and causes multiple toxic effects, including immune dysregulation, neurotoxicity, and reproductive toxicity. [2][3][4] It is a wellknown RNA, DNA, and protein synthesis inhibitor, that exerts toxic effects by activating several signaling pathways, such as the mitogen-activated protein kinase (MAPK) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways by targeting mitochondria, ribosomes and the endoplasmic reticulum. 3,5,6 Interestingly, an increasing number of studies have revealed that T-2 toxin can selectively upregulate a group of mRNAs and proteins involved in inflammatory responses, metabolic pathways, and signal transduction to mediate T-2 toxininduced cytotoxicity, including DNA damage, apoptosis, and growth inhibition.…”

Section: Introductionmentioning

confidence: 99%

“…Mycotoxins are toxic secondary metabolites produced by fungi that usually cause food contamination and lead to mycotoxicosis in farm animals and humans 1 . T‐2 toxin is one of the most toxic trichothecene mycotoxins and causes multiple toxic effects, including immune dysregulation, neurotoxicity, and reproductive toxicity 2‐4 . It is a well‐known RNA, DNA, and protein synthesis inhibitor, that exerts toxic effects by activating several signaling pathways, such as the mitogen‐activated protein kinase (MAPK) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathways by targeting mitochondria, ribosomes and the endoplasmic reticulum 3,5,6 .…”

Section: Introductionmentioning

confidence: 99%

Role of DNA methylation‐related chromatin remodeling in aryl hydrocarbon receptor‐dependent regulation of T‐2 toxin highly inducible Cytochrome P450 1A4 gene

et al. 2021

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Mycotoxins are toxic secondary metabolites produced by food-contaminating fungi, which lead to global epigenetic changes and cause toxicity to both farm animals and humans. However, whether mycotoxins induce gene-specific epigenetic alterations associated with inducible downstream gene expression is unclear as are the underlying regulatory mechanisms. Here, we found that T-2 toxin and its deacetylated metabolites but not deoxynivalenol (DON) or other representative mycotoxins highly induced the expression of cytochrome P450 1A4 (CYP1A4) in both Leghorn male hepatoma (LMH) cells and chicken primary hepatocytes, and this effect was related to the regulation of both aryl hydrocarbon receptor (AhR) and DNA methylation. We used methylation-sensitive restriction enzyme digestion-qPCR (MSRE-qPCR) and chromatin immunoprecipitation (ChIP) assays and found that the binding of DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) to highly methylated CpG island 3-2 at the enhancer of CYP1A4 was accompanied by the recruitment of the repressive histone modification marker H3K27me3, inducing a silent state. In turn, T-2 toxin stimulation enriched the binding of AhR to demethylated CpG island 3-2, which facilitated p300 and H3K9ac recruitment and ultimately generated an activated chromatin structure at the enhancer by increasing the active histone modification markers, including H3K4me3, H3K27ac, and H3K14ac. Interestingly, T-2 2 of 15 | JIANG et Al.

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Review of the Reproductive Toxicity of T-2 Toxin

Cited by 63 publications

References 76 publications

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases

Fungal diversity and mycotoxin contamination in dried fish products in Zhanjiang market, China

Role of DNA methylation‐related chromatin remodeling in aryl hydrocarbon receptor‐dependent regulation of T‐2 toxin highly inducible Cytochrome P450 1A4 gene

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