L-arginine induces dopamine release from the striatum in vivo

Strasser, Alois; McCarron, Richard M.; Ishii, Hisato; Stanimirovic, Danica; Spatz, Maria

doi:10.1097/00001756-199411000-00023

Cited by 93 publications

(45 citation statements)

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“…Whereas the release of ACh alone may trigger this switch in firing mode (Eysel et al, 1986;McCormick andPrince, 1986, 1987;Francesconi et al, 1988;McCormick and Pape, 1988;McCormick, 1989), NO released from PBR terminals, in addition, may modulate neurotransmitter release and receptor activation (Lonart et al, 1992;Lorrain and Hull, 1993;Guevara-Guzman et al, 1994;Strasser et al, 1994;Silva et al, 1995) or may influence more directly the membrane properties of thalamocortical cells (Pape and Mager, 1992;Cudeiro et al, 1994aCudeiro et al, ,b, 1996Murphy et al, 1994). Thus, the dual release of ACh and NO in the LGN may mediate a complex enhancement of thalamocortical cell responses.…”

Section: Functional Implicationsmentioning

confidence: 99%

Two types of interneurons in the cat visual thalamus are distinguished by morphology, synaptic connections, and nitric oxide synthase content

Patel

1999

J. Comp. Neurol.

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Section: Functional Implicationsmentioning

confidence: 99%

Two types of interneurons in the cat visual thalamus are distinguished by morphology, synaptic connections, and nitric oxide synthase content

Patel

1999

J. Comp. Neurol.

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“…For example, NO has been shown to increase tyro sine hydroxylase activity and to potentiate presynaptic catecholamine release [17]. Z.-Ar ginine induces dopamine release from the striatum in vivo and NNA, an inhibitor of NOS, markedly reduces the effect of L-argi nine on dopamine release [18]. It has also been shown that NO inhibits uptake of [3H]dopamine from rat striatal synaptosomes CNS NOS in M orphine W ithdrawal Pharmacology 1996:52:86-91 [19].…”

Section: Discussionmentioning

confidence: 99%

Evidence for a Role of Nitric Oxide of the Central Nervous System in Morphine Abstinence Syndrome

Bhargava

Thorat²

1996

Pharmacology

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Two potent inhibitors of nitric oxide synthase (NOS), namely, N^G-nitro-L-arginine (NNA) and N^G-monomethyl-L-arginine (NMMA) were administered intracerebroventricularly (i.c.v.) in morphine-dependent mice to investigate their effects on abrupt withdrawal and naltrexone-precipitated abstinence signs. Male Swiss-Webster mice were rendered dependent on morphine by subcutaneous implantation of a morphine pellet containing 75 mg of morphine base. Mice implanted with placebo pellets served as controls. NMMA or NNA administered i.c.v. had minimal effects on body weight loss and hypothermia that occur during abrupt withdrawal of morphine. When administered i.c.v., both NNA or NMMA (0.1, 1 and 10 µg/ mouse) dose-dependently inhibited naltrexone-induced stereotyped jumping behavior in mice. I.c.v. administration of NMMA also attenuated withdrawal induced fecal pellet formation. This effect, however, was not dose-dependent. In conclusion, these results suggest that brain NO plays an important role in the expression of behavioral signs of morphine withdrawal syndrome. In addition, these results support the idea that NOS inhibitors may be potentially useful in the treatment of opioid withdrawal syndrome.

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“…Systemic infusion of arginine increases the plasma insulin, glucagon, and prolactin levels (MacAllister et al, 1995). Also, arginine, through nitric oxide (NO), stimulates the release of dopamine from the striatum in gerbils (Strasser et al, 1994), increases the tumoricidal and bactericidal actions of macrophages (DiLorenzo et al, 1995), stimulates wound healing (Sac, 1994), and has neurotransmitter functions in the brain (Lefebvre, 1995).…”

Section: Argininementioning

confidence: 99%

A review of physiological and metabolic effects of essential amino acids

1998

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The authors review ten essential amino acids with regard to their metabolic, physiologic and therapeutic effects throughout the human body. Physical properties of these biologically active compounds are discussed as a foundation for their diverse roles in special nitrogen containing products, neurotransmitters, and as alternative energy sources. Both normal and abnormal amino acid metabolism are considered in the areas of digestion, elimination of metabolic products, metabolic intermediates, and defects in these systems. Recent developments in therapeutic applications are further examined for clinical utility and as an economical alternative to traditional clinical treatment modalities.

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L-arginine induces dopamine release from the striatum in vivo

Cited by 93 publications

References 0 publications

Two types of interneurons in the cat visual thalamus are distinguished by morphology, synaptic connections, and nitric oxide synthase content

Two types of interneurons in the cat visual thalamus are distinguished by morphology, synaptic connections, and nitric oxide synthase content

Evidence for a Role of Nitric Oxide of the Central Nervous System in Morphine Abstinence Syndrome

A review of physiological and metabolic effects of essential amino acids

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