l-Arginine and Its Transporters in Colorectal Cancer

Chen, Bing-guan; Wang, Weimin; Ding, Kang; Wang, Junchen; Gao, Peng; Xu, Guowang; Hu, Hai

doi:10.1007/978-3-319-26009-9_19

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…The genus belongs to the family Veillonellaceae under the order Veillonellales, class Negativicutes, and phylum Firmicutes (Maki and Looft, 2018). Previous studies have demonstrated that M. elsdenii could metabolize lactate and buffer fat and produce acetate, propionate, and butyrate (Chen and Wang, 2016;Chen et al, 2019). These shortchain fatty acids may act through down-regulating cholesterol biosynthesis and increasing the bile acid excretion to regulate the lipid levels (Illman et al, 1988;Marcil et al, 2003;Falcinelli et al, 2015Falcinelli et al, , 2018.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats

et al. 2022

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Emerging evidence has been reported to support the involvement of the gut microbiota in the host’s blood lipid and hyperlipidemia (HLP). However, there remains unexplained variation in the host’s blood lipid phenotype. Herein a nonhuman primate HLP model was established in cynomolgus monkeys fed a high-fat diet (HFD) for 19 months. At month 19%, 60% (3/5) of the HFD monkeys developed HLP, but surprisingly 40% of them (2/5) exhibited strong tolerance to the HFD (HFD-T) with their blood lipid profiles returning to normal levels. Metagenomic analysis was used to investigate the compositional changes in the gut microbiota in these monkeys. Furthermore, the relative abundance of Megasphaera remarkably increased and became the dominant gut microbe in HFD-T monkeys. A validation experiment showed that transplantation of fecal microbiota from HFD-T monkeys reduced the blood lipid levels and hepatic steatosis in HLP rats. Furthermore, the relative abundance of Megasphaera significantly increased in rats receiving transplantation, confirming the successful colonization of the microbe in the host and its correlation with the change of the host’s blood lipid profiles. Our results thus suggested a potentially pivotal lipid-lowering role of Megasphaera in the gut microbiota, which could contribute to the variation in the host’s blood lipid phenotype.

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Section: Discussionmentioning

confidence: 99%

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats

et al. 2022

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“…Papers may therefore have been incorrectly considered as individual studies, resulting in an overestimation of the total number of patients in the identified studies. Regarding the usage of the NOS scale to judge the methodological quality of studies, the cutoff points to define the demarcation between high-, moderate-and low-quality scores vary in the literature, with some authors defining 8 out of nine as highquality whereas others define 6 out of nine as highquality [42][43][44][45][46]. In our study we defined a score of minimum 6 stars out of seven as a high-quality score.…”

Section: Discussionmentioning

confidence: 99%

Outcome measures used in clinical studies on neonatal brachial plexus palsy: A systematic literature review using the International Classification of Functioning, Disability and Health

Sarac

Duijnisveld

Weide

et al. 2015

PRM

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“…The North country can contrast the offshoring process by decreasing the value of ξ. The standard way to obtain this result is to impose a duty on importation so that the difference between the production cost in the North and the South country decreases (see, e.g., [17,18]).…”

Section: Proof Of Proposition 1 Let Us Consider (22) We Notice That T...mentioning

confidence: 99%

A Binary-State Continuous-Time Markov Chain Model for Offshoring and Reshoring

Brambilla,

Grosset,

Sartori

2024

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We present a two-country model (North and South) that describes the phenomenon of offshoring and reshoring. The model is a continuous time-controlled Markov chain with binary states. The main trade-off involves production costs and transaction costs between one country and another. In the first part of this paper, we identify the key parameters of the model: the difference in unit production costs between the two countries considered, the marginal cost of transitioning between countries, and the incentive paid by the North country to all companies that have not relocated at the end of the planning interval. The final goal of our paper is to understand how national tax incentives can influence this process.

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l-Arginine and Its Transporters in Colorectal Cancer

Cited by 4 publications

References 48 publications

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats

Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats

Outcome measures used in clinical studies on neonatal brachial plexus palsy: A systematic literature review using the International Classification of Functioning, Disability and Health

A Binary-State Continuous-Time Markov Chain Model for Offshoring and Reshoring

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