l-Arginine Administration During Reperfusion Improves Pulmonary Function

No effect of L‐arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass

“…Administration of exogenous L‐arginine has in most experimental studies been demonstrated to reduce reperfusion injury, for example, reduce infarct size (8, 9,16), preserve postischemic systolic and diastolic regional function (16), reduce neutrophil accumulation (8, 9) and preserve endothelial function (8, 9, 16) in the heart. In the lungs, improved oxygenation, lung compliance (12) and better preserved ACH reactivity in pulmonary artery rings (13) have been demonstrated. In other organs, administration of exogenous arginine also had positive effects, with improved microcirculation and reduced enzyme release in a perfused rat liver preparation (14), less edema formation, superoxide release and increased NO concentration in rabbit hindlimb (11).…”

“…Ischemia‐reperfusion causes endothelial dysfunction and is followed by an attenuated agonist stimulated NO release (4–9) as well as a diminished basal endothelial NO production (6, 10, 11) and, as a consequence, an increased adherence of leukocytes and platelets to the endothelium. Various therapeutic approaches related to nitric oxide have been tested in order to decrease or prevent reperfusion injury (7–9, 11–17). Since L‐arginine is the precursor of NO, administration of exogenous arginine in order to increase the blood concentration could theoretically improve the production of NO.…”

Alterations in L-Arginine Metabolism After Lung Transplantation~!2009-11-12~!2010-03-25~!2010-05-04~!

“…While in some studies beneficial effects of L-arginine supplementation were described in animal models i.e. prevention of pulmonary endothelial damage after reperfusion [81,82] or improved oxygenation [83], others could not observe effects of L-arginine on pulmonary hemodynamics, gas exchange, or leukocyte sequestration of the transplanted lung [84].…”

l-Arginine Inhibits Ischemia–Reperfusion Lung Injury in Rabbits

“…The leukocyte adhesion induced by L-NAME is reversed by L-arginine [21]. In addition, L-arginine administration during reperfusion improved pulmonary function, making it a simple alternative to leukocyte depletion [6] and inhibiting platelet aggregation [22]. It is reported that NO acts as a scavenger of superoxide anion [23].…”

“…Normandin et al reported that inhalation of NO reduced IR lung injury by preventing microvascular injury and endothelial dysfunction [3]. Infusion of the NO precursor L-arginine reduces IRinduced cardiac [4] and lung injury [3,5,6]. As for lung preservation, it is reported that addition of L-arginine during reperfusion prevents pulmonary endothelial dysfunction [3].…”