l-3,4-Dihydroxyphenylalanine templated anisotropic gold nano/micro-roses as potential disrupters/inhibitors of α-crystallin protein and its gleaned model peptide aggregates

Kour, Avneet; Sharma, Sucheta; Dube, Taru; Bisht, Anjali; Sharma, Manju; Mishra, Jibanananda; Ali, Md. Ehesan; Panda, Jiban Jyoti

doi:10.1016/j.ijbiomac.2020.09.112

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…To evaluate the disaggregation potency of PVDF and DPVDF nanospheres towards Aβ42 polypeptide fibrils, Aβ42 polypeptide fibrils (20 μM) were prepared by adopting a similar protocol as mentioned earlier. 90 In disaggregation studies, PVDF and DPVDF nanospheres (800 μg mL −1 ) were added to the prepared Aβ42 polypeptide fibrils. Samples were then exposed to an acoustic stimulus (at 40 kHz) for half an hour.…”

Section: Determination Of the Disaggregation Potency Of Pvdf And Dpvd...mentioning

confidence: 99%

Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Sharma,

Choudhury,

Babu

et al. 2024

Biomater. Sci.

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Section: Determination Of the Disaggregation Potency Of Pvdf And Dpvd...mentioning

confidence: 99%

Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Sharma,

Choudhury,

Babu

et al. 2024

Biomater. Sci.

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“…36,37 A large number of PfK13 mutations have been associated with artemisinin resistance, 19,21,26 however, it is not yet known why do these specific mutations instigate drug resistance. In this work, we have investigated the structural dynamics of PfK13 wild-type (WT) and four mutant protein structures by adopting the classical molecular dynamic simulations [38][39][40] to address the issue and established a correlation of the protein dynamics with the artemisinin drug resistance.…”

Section: Introductionmentioning

confidence: 99%

How do the Mutations in PfK13 Protein Promote Anti-malarial Drug Resistance?

Sharma¹,

Ali²

2022

Preprint

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Plasmodium falciparum develops resistance to artemisinin upon exposure to the anti-malarial drug. Various mutations in the Plasmodium falciparum Kelch13 (PfK13) protein such as Y493H, R539T, I543T, and C580Y have been associated with antimalarial drug resistance. (Ariey et al., Nature, 2014, 505, 50-55) These mutations impede the regular ubiquitination process that eventually invokes drug resistance. However, the relationship between the mutation and the mechanism of drug resistance has not yet been fully elucidated. The comparative protein dynamics are studied by performing the classical molecular dynamics (MD) simulations and subsequent analysis of the trajectories adopting root-means-square fluctuations, the secondary-structure predictions and the dynamical cross-correlation matrix analysis tools. Here we observed that the mutations in the Kelch-domain does not have any structural impact on the mutated site, however, it significantly alters the overall dynamics of the protein. The loop-region of the BTB-domain especially for Y493H and C580Y mutants are found to have the enhanced dynamical fluctuations. The enhanced fluctuations in the BTB-domain could affect the protein-protein (PfK13-Cullin) binding interactions in the ubiquitination process and eventually leads to anti-malarial drug resistance.

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Insights into the role of the conserved GTPase domain residues T62 and S277 in yeast Dnm1

Banerjee,

Mukherjee,

Adhikary

et al. 2023

International Journal of Biological Macromolecules

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l-3,4-Dihydroxyphenylalanine templated anisotropic gold nano/micro-roses as potential disrupters/inhibitors of α-crystallin protein and its gleaned model peptide aggregates

Cited by 5 publications

References 57 publications

Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

How do the Mutations in PfK13 Protein Promote Anti-malarial Drug Resistance?

Insights into the role of the conserved GTPase domain residues T62 and S277 in yeast Dnm1

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