Abstract:Plasmodium falciparum develops resistance to artemisinin upon exposure to the anti-malarial drug. Various mutations in the Plasmodium falciparum Kelch13 (PfK13) protein such as Y493H, R539T, I543T, and C580Y have been associated with antimalarial drug resistance. (Ariey et al., Nature, 2014, 505, 50-55) These mutations impede the regular ubiquitination process that eventually invokes drug resistance. However, the relationship between the mutation and the mechanism of drug resistance has not yet been fully eluc… Show more
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