Kyrle's disease. I. Clinical findings in five cases and review of literature

Ocular Findings in a Kindred With Kyrle Disease

“…-Left, skin biopsy specimen from pa¬ tient 11-6 showing large keratotic plug filling epithelial invagination. Site of penetration is not present but mononuclear inflammatory in¬ filtrates are present in dermis (arrows) (hematoxylin-eosin, original magnification x35).…”

Progressive Generalized Perforating Folliculitis

“…At a cer tain stage the facial appearance resembled a lithium-induced acneiform eruption, but at that time our patient had been without lithi um for 1 year, and no traces of lithium were found in the skin, the remnants of hair, nor in the blood. Clinically and histologically the disease also differed from Kyrle's disease [1,2]. Clin ically important in this respect is again the localization of the dominating lesions, which were most pronounced in the face and its seborrheic areas.…”

Kyrle’s Disease: A Rare Presentation in Diabetic and Hypertensive Patients

“…In most instances, it is important to perform elastic tissue stains and even trichrome stains to exclude perforating elastic fibers, as in EPS, or collagen fibers, as in RPC. 3 The histogenesis is attributed to a primary event of disturbance in epidermal keratinization characterized by the formation of dyskeratotic foci and acceleration of the process of keratinization. This leads to the formation of keratotic plugs with areas of parakeratosis.…”