Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway

Ma, Ruijiao; Maharajan, Kannan; Xia, Qing; Zhang, Shanshan; Tu, Pengfei; Liu, Kechun; Zhang, Yun

doi:10.1007/s11655-022-3625-5

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Besides, these pathways are also involved in inducing apoptosis via the PI3K/AKT/mTOR signaling pathway. Another recently study has reported the anti-angiogenic activity of KX in Zebrafish embryos through PI3K/AKT-MAPK-VEGF pathway ( Ma et al, 2023 ). In T. hypoglaucum , more than 500 metabolites were identified, which include alkaloids, flavonoids, sesquiterpenes, lignans, diterpenes, triterpenes, and glycosides ( Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Tang et al reported that KX shows treatment effects in RA by inhibiting inflammatory responses and inducing apoptosis via the PI3K/AKT/mTOR signaling pathway ( Tang, Zhang, Li, Xie, & Huang, 2020 ). Recently, the anti-angiogenic effect of KX extract was reported in zebrafish embryos through the intersegmental vessels and sub-intestinal vein formation via PI3K/AKT-MAPK-VEGF pathway ( Ma et al, 2023 ).…”

Section: Clinical Applications Of Kx and Their Therapeutic Effectsmentioning

confidence: 99%

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Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review

Maharajan

Zhuang

et al. 2023

Chinese Herbal Medicines

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Section: Discussionmentioning

confidence: 99%

Section: Clinical Applications Of Kx and Their Therapeutic Effectsmentioning

confidence: 99%

Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review

Maharajan

Zhuang

et al. 2023

Chinese Herbal Medicines

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“…Shexiang Zhuifeng analgesic plaster decreased nitric oxide (NO) production in RAW 264.7 cells (Wang et al, 2023). In zebrafish embryos, Kunxian Capsule displayed anti-angiogenic actions through the controlling of the PI3K/AKT-MAPK-VEGF pathway (Ma et al, 2023). Sidaxue is a Miao prescriptions known in the research work of Miao medicine.…”

Section: Prescriptionsmentioning

confidence: 99%

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Gao,

Song,

Chen

et al. 2024

Front. Pharmacol.

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Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia and inflammation underlies joint destruction. Delaying or even blocking synovial angiogenesis has emerged as an important target of RA treatment. Natural medicines has a long history of treating RA, and numerous reports have suggested that natural medicines have a strong inhibitory activity on synovial angiogenesis, thereby improving the progression of RA. Natural medicines could regulate the following signaling pathways: HIF/VEGF/ANG, PI3K/Akt pathway, MAPKs pathway, NF-κB pathway, PPARγ pathway, JAK2/STAT3 pathway, etc., thereby inhibiting angiogenesis. Tripterygium wilfordii Hook. f. (TwHF), sinomenine, and total glucoside of Paeonia lactiflora Pall. Are currently the most representative of all natural products worthy of development and utilization. In this paper, the main factors affecting angiogenesis were discussed and different types of natural medicines that inhibit angiogenesis were systematically summarized. Their specific anti-angiogenesis mechanisms are also reviewed which aiming to provide new perspective and options for the management of RA by targeting angiogenesis.

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Effects of dietary supplementation of different ratios of koumine and gelsemin on the liver immunity of common carp (Cyprinus carpio, FFRC)

Sun,

Ye,

Wang

et al. 2024

Aquaculture

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Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway

Cited by 3 publications

References 29 publications

Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review

Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review

The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis

Effects of dietary supplementation of different ratios of koumine and gelsemin on the liver immunity of common carp (Cyprinus carpio, FFRC)

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