KTP Laser Excision of a Soft Palate Squamous Cell Carcinoma: A Case Report

Sheridan, Mark F.; Zieske, Larry A.

doi:10.1093/milmed/159.1.75

Cited by 5 publications

(3 citation statements)

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“…KTP laser light also has been used surgically after coupling to a bare fiber in both the contact mode and noncontact mode with reported clinical effectiveness in controlling bleeding disorders as well as tongue and soft palate cancer resections in addition to laryngeal cancer treatment [21,22]. KTP laser fiberoptics recently were tested for interstitial treatment of transplanted human squamous-cell tumors after injection of the anthrapyrazole CI-941 [9,10].…”

Section: Discussionmentioning

confidence: 99%

Improved photochemotherapy of malignant cells with daunomycin and the KTP laser

et al. 1998

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Section: Discussionmentioning

confidence: 99%

Improved photochemotherapy of malignant cells with daunomycin and the KTP laser

et al. 1998

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“…The potassium‐titanyl‐phosphate (KTP532) laser has been reported to be beneficial especially for the treatment of less advanced lesions although the neodymium yttrium‐aluminum‐garnet (Nd:YAG) infrared laser has a much wider clinical use in cancer therapy. Sheridan and Zieske 22 . reported successful treatment of a 4‐mm thick T2N0M0 soft palate SCCA with the KTP laser under local anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Anthrapyrazoles and Interstitial Laser Phototherapy for Experimental Treatment of Squamous Cell Carcinoma

et al. 1998

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Interstitial laser therapy (ILT) is an effective palliative treatment for advanced head and neck cancer, but recurrence often is seen at the margin. The objective of the current study was to test combined drug and laser therapy as an experimental approach for improved treatment of human squamous cell carcinoma (SCCA). Human SCCA tumor transplants were grown in nude mice and injected with the photosensitive anthrapyrazole CI-941 before ILT. Intralesional drug injections alone at levels ranging from 60 to 1200 microg/gm of tumor induced a growth delay at the higher doses, but recurrence was seen in all 35 tumors tested. SCCA tumor transplants injected with 240 microg/gm CI-941 followed after 4 hours by ILT with the KTP532 laser led to a complete response rate of 72% (21/29) compared with 45% (13/29) for ILT alone. Laser chemotherapy was a significant improvement compared with ILT when partial and complete responses were combined (P < 0.03). The results provide preclinical evidence that laser chemotherapy may become a useful minimally invasive treatment for advanced squamous cell carcinoma of the head and neck.

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“…Interstitial laser therapy (ILT) delivered via submillimeter fiberoptics is a less invasive method to produce localized hyperthermia focused in the treatment site. KTP-532 and Nd:YAG lasers are currently used clinically for ILT in a number of human malignancies [13][14].…”

Section: Introductionmentioning

confidence: 99%