“…Head and neck tumors are an excellent disease model for testing intratumor chemotherapy and laser because of their accessibility for surgery and their loco-regional biological behavior . The laser energy can be delivered via interstitial fiber optics using drugs activated by photo-chemical and photo-thermal energy as a potential less invasive treatment alternative for cancer (Paiva et al, 2005c;Paiva et al, 1997;Graeber et al, 1999). Moreover, there has been no generally accepted standard of care for recurrent head and neck cancer (Goodwin et al, 2000;D'Cruz et al, 2004;Arnold et al, 2004;Fury et al, 2011).…”