Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

Nd:YAG laser therapy for palliation of recurrent squamous cell carcinomas in the oral cavity

“…These undertreated areas in the periphery previously were sites of tumor recurrence, which may be prevented by local chemotherapy with heat-sensitive anti-cancer drugs. Cisplatin is a promising drug for use in conjunction with photo-thermal laser therapy because its cytotoxicity is enhanced at elevated temperatures [24,25]. Further efforts to develop laser treatment methods should provide less invasive and more effective therapy for patients with recurrent tumors.…”

“…Our clinical experience has confirmed previous reports suggesting the safety and feasibility of this technique [3,11,15]. We are currently investigating a new combination of chemotherapy and laser thermal ablation to further enhance tumor treatment [24]. High photothermal energy levels are delivered to the central tumor area and lower levels to the periphery.…”

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

“…Head and neck tumors are an excellent disease model for testing intratumor chemotherapy and laser because of their accessibility for surgery and their loco-regional biological behavior . The laser energy can be delivered via interstitial fiber optics using drugs activated by photo-chemical and photo-thermal energy as a potential less invasive treatment alternative for cancer (Paiva et al, 2005c;Paiva et al, 1997;Graeber et al, 1999). Moreover, there has been no generally accepted standard of care for recurrent head and neck cancer (Goodwin et al, 2000;D'Cruz et al, 2004;Arnold et al, 2004;Fury et al, 2011).…”

“…Toxicity enhancement of cisplatin at these temperatures (40-60 o C) would promote optimal eradication of cancer cells at the tumor margins. Under such rationale, enhanced laser therapy by adjuvant local chemotherapy using CDDP/gel in the region of subtherapeutic energy levels was first demonstrated in an experimental model by Paiva et al (1997). Using authographic imaging method, Kanekal et al (1995) tested cisplatin radiotracer in suspension ( 195m Pt-CDDP, 4mg/ml) and gel implant form ( 195m Pt-CDDP/gel, 4mg/ml) to compare tumor retention in 600mm 3 subcutaneous tumors in experimental murine model.…”

Laser and cisplatinum for treatment of human squamous cell carcinoma

“…Reports from several investigators indicate drug cytotoxicity of CDDP is enhanced by local or systemic hyperthermia 13 . Tumor hyperthermia been tested clinically for nearly two decades as a cancer treatment and is reported to enhance tumoricidal effects of irradiation as well as several chemotherapeutic agents including Adriamycin derivatives and cisplatinum 14–18 . The nature of hyperthermia‐induced lethality is quite different from radiation‐induced killing.…”