Nd:YAG laser therapy for palliation of recurrent squamous cell carcinomas in the oral cavity

Paiva, Marcos B.; Blackwell, Keith E.; Saxton, Romaine E.; Bublik, Michael; Liu, Carson D.; Paolini, A; Calcaterra, Thomas C.; Castro, Dan J.

doi:10.1002/lsm.10077

Cited by 24 publications

(17 citation statements)

References 24 publications

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“…Recently, Paiva et al highlighted the importance of this laser in treatment of recurrent SCC [7]. This study reports a 58% ablation rate in 17 cases resistant to all other modalities of treatment.…”

Section: Discussionmentioning

confidence: 89%

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Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Tewari

Rai

Singh

et al. 2007

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 89%

“…Post treatment recurrences are seen in 50% of cases, and in such cases, the mortality rates are high [7]. In India, it is the commonest malignancy.…”

Section: Discussionmentioning

confidence: 99%

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Tewari

Rai

Singh

et al. 2007

Journal of Surgical Oncology

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“…For example, for the treatment of liver cancers, laser energy is delivered through optical fibers inserted into the tumor under imaging guidance [2, 3]. Laser-induced PTA has also been evaluated as an alternative to radical surgery for advanced and recurrent head and neck squamous cell carcinoma [7, 8]. However, because of absorption by normal tissues, the amount of energy deposited to the treatment volume is limited, which reduces the potency of the thermal killing effect.…”

Section: Introductionmentioning

confidence: 99%

Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release

You

Zhang

et al. 2012

Journal of Controlled Release

202

142

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Photothermal ablation (PTA) is an emerging technique that uses near-infrared (NIR) laser light-generated heat to destroy tumor cells. However, complete eradication of tumor cells with PTA is difficult because of uneven heat distribution in the treatment volume. We hypothesized that combining PTA with chemotherapy using a single multifunctional nanoconstruct that mediates simultaneous photothermal cell killing and drug release (photothermal-chemotherapy) would result in enhanced antitumor activity and reduced toxicity compared to chemotherapy alone. Doxorubicin (DOX) was loaded to hollow gold nanospheres (HAuNS) coated with polyethylene glycol (PEG). The pharmacokinetics and biodistribution of both DOX and HAuNS in the resulting nanoconstruct, DOX@PEG-HAuNS having different DOX:PEG:HAuNS ratios, were evaluated using dual isotope labeling techniques. The antitumor activity of DOX@PEG-HAuNS with DOX:PEG:HAuNS weight ratio of 1:3:1 (NP3) in combination with NIR laser was studied in vitro and in vivo using human MDA-MB-231 breast cancer and A2780 ovarian cancer cells. In vitro, NP3 mediated PTA of both cancer cells and DOX release upon NIR laser treatment. In vivo, NP3 showed slower clearance in blood and greater accumulation in tumors than free DOX. NP3-plus-NIR laser demonstrated greater antitumor activity than free DOX, NP3, or liposomal DOX. Moreover, NP3 displayed significantly decreased systemic toxicity compared to free DOX or liposomal DOX. Enhanced antitumor effect with NP3-plus-laser can be attributed to both the cytotoxic effect of DOX released from NP3 and the photothermal effect mediated by HAuNS. Slow release of DOX from NP3 in normal tissues contributed to reduced systemic toxicity. Photothermal-chemotherapy exemplified by a single-agent nanoconstruct NP3 is a promising approach to anticancer therapy.

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“…1,2 In the past decade, near-infrared light-responsive inorganic nanoparticles, such as gold nanoparticles, 3−7 carbon nanotubes, 8 and CuS nanoparticles, 9−13 have been shown to efficiently convert optical energy into thermal energy and enhance the efficacy of photothermal ablation therapy. Some applications are under clinical trials.…”

mentioning

confidence: 99%

Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles

et al. 2014

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Near-infrared light-responsive inorganic nanoparticles have been shown to enhance the efficacy of cancer photothermal ablation therapy. However, current nanoparticle-mediated photothermal ablation is more effective in treating local cancer at the primary site than metastatic cancer. Here, we report the design of a near-infrared light-induced transformative nanoparticle platform that combines photothermal ablation with immunotherapy. The design is based on chitosan-coated hollow CuS nanoparticles that assemble the immunoadjuvants oligodeoxynucleotides containing the cytosine-guanine (CpG) motifs. Interestingly, these structures break down after laser excitation, reassemble, and transform into polymer complexes that improve tumor retention of the immunotherapy. In this “photothermal immunotherapy” approach, photothermal ablation-induced tumor cell death reduces tumor growth and releases tumor antigens into the surrounding milieu, while the immunoadjuvants potentiate host antitumor immunity. Our results indicated that combined photothermal immunotherapy is more effective than either immunotherapy or photothermal therapy alone against primary treated and distant untreated tumors in a mouse breast cancer model. These hollow CuS nanoparticles are biodegradable and can be eliminated from the body after laser excitation.

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Nd:YAG laser therapy for palliation of recurrent squamous cell carcinomas in the oral cavity

Abstract: Nd:YAG laser treatment of recurrent oral cavity squamous cell carcinoma can be performed safely and repeated as needed to achieve tumor palliation. However, extended follow-up may be needed before convincing evidence of long-term therapeutic benefits is obtained.

Cited by 24 publications

References 24 publications

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release

Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles

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