Kritisches über das „Vitamin P”

Lotze, Harald

doi:10.1055/s-0028-1122124

Cited by 9 publications

(9 citation statements)

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“…His findings confirmed that citrin was effective in restoring normal capillary resistance from scorbutogenic dietary conditions. Unfortunately, several workers, notably Zilva ( 19 , 43 ), were not able to duplicate the effects of citrin and its interactions with VitC as claimed by Moll ( 44 ), Lotze ( 45 ), and Parrot and Sevestre ( 46 ). Even Szent-Györgyi was not always able to duplicate his own results ( 47 , 48 ).…”

Section: Early Evidence For Vitamin P As a Flavonoidmentioning

confidence: 99%

Do Certain Flavonoid IMPS Have a Vital Function?

et al. 2021

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Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of disparate subgroups, yet undergo a certain degree of metabolic interconversion. Unsurprisingly, flavonoids have been an important theme in nutrition research. Already in the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to that of plant extracts containing Vitamin C. Subsequent experimental evidence led to the proposal of Vitamin P (permeability) as an essential phytochemical nutrient. However, attempts to isolate and characterize Vitamin P gave confusing and sometimes irreproducible results, which today can be interpreted as rooted in the unrecognized (residual) complexity of the intervention materials. Over the years, primarily flavonoids (and some coumarins) were known as having Vitamin P-like activity. More recently, in a NAPRALERT meta-analysis, essentially all of these Vitamin P candidates were identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas). While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition for “bioflavonoids,” the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition at the interface of vitamins, cofactors, and micronutrients. Reviewing 100+ years of the multilingual Vitamin P and C literature provides the rationales for this conclusion and new perspectives for future research.

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Section: Early Evidence For Vitamin P As a Flavonoidmentioning

confidence: 99%

Do Certain Flavonoid IMPS Have a Vital Function?

et al. 2021

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“…His findings confirmed that citrin was effective in restoring normal capillary resistance from scorbutogenic dietary conditions. Unfortunately, several workers, notably Zilva (18,42), were not able to duplicate the effects of citrin and its interactions with Vitamin C as claimed by Szent-Györgyi and coworkers (43)(44)(45).…”

Section: Vitamin P Early Evidence For Vitamin P As a Flavonoidmentioning

confidence: 99%

“…Lavollay demonstrated that injection of pure, synthetic Vitamin C caused elevation of capillary resistance in non-scorbutic guinea pigs (2 mg per 400 g animal), whereas injection of the flavanone, epicatechin (3a; 1 μg), was 10,000 to 20,000 times more effective than 1. Others also have not detected any increase in capillary resistance following administration of 1 alone to apparently healthy persons on inadequate diets or to persons with scurvy (44,(51)(52)(53). Interestingly, a very recent meta analysis of 17 qualifying clinical trials has associated the flavonoid quercetin with lowered systolic blood pressure as a clinical endpoint, in the absence of lipid and glucose metabolic effects (39).…”

Section: Vitamin P Early Evidence For Vitamin P As a Flavonoidmentioning

confidence: 99%

“…This problem, coupled with the difficulty in attributing a deficiency disease that could clearly be linked to Szent-Györgyi's lemon extracts or to Vitamin P might have led scientists to abandon Vitamin P as a useful hypothesis. Nonetheless, despite the difficulties in understanding the relation of Vitamins C and P, two things have been established: (i) the existence of a distinct biological effect of Vitamin P, i.e., the influence of a series of naturally occurring flavonoids and coumarins ( Figure 1 and Figure S1, Supporting Information) on vascular permeability; and (ii) the influence of these natural products on the anti-scurvy effect of Vitamin C (44,48,65).…”

Section: Expanding the Repertoire Of Vitamin P Candidatesmentioning

confidence: 99%

“…A control group was given Vitamin C, whereas other groups received no or sub-optimal levels of Vitamin C, but were given various levels of OP(A)Cs. Even though deprived of Vitamin C, those that received an appropriate amount of OP(A)Cs survived as long as those that got adequate amounts of Vitamin C. Lotze concluded that Vitamin C and OP(A)Cs have a marked synergy because coadministration of OP(A)Cs and Vitamin C made it possible to decrease the dosage of Vitamin C (21,44,52,96). Pleiotropic effects (multiple biological effects from the same phytoconstituent) may also explain bioactivity that cannot be rationalized by classical reductionist models (67).…”

Section: Are Vitamin C and Vitamin P Mutual Co-factors?mentioning

confidence: 99%

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Vitamin P – Do Certain Polyphenolic IMPS Have a Vital Function?

Pauli¹

2020

Preprint

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Abbreviations used: IMPS, invalid/improbable/interfering metabolic panaceas; PAC, proanthocyanidins; OPAC, oligomeric proanthocyanidins. AbstractIn the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to plant extracts containing Vitamin C. This observation led to the proposal of Vitamin P (permeability), as an essential phytochemical dietary nutrient. Subsequent attempts to isolate and characterize Vitamin P led to confusing and sometimes irreproducible results. Over the years several flavonoids and coumarins have been identified as having Vitamin P-like activity.Essentially all of these Vitamin P candidates were recently identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas) in a NAPRALERT meta analysis. While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition, the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition. This review of 100+ years of multilingual Vitamin P and C literature provides the rationales for this conclusion.

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The chemical nature of hesperidin and its experimental medical use as a source of vitamin P—a review

Higby

1941

Journal of the American Pharmaceutical Association (Scientific

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Kritisches über das „Vitamin P”

Cited by 9 publications

References 0 publications

Do Certain Flavonoid IMPS Have a Vital Function?

Do Certain Flavonoid IMPS Have a Vital Function?

Vitamin P – Do Certain Polyphenolic IMPS Have a Vital Function?

The chemical nature of hesperidin and its experimental medical use as a source of vitamin P—a review

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