Kritische Beurteilung des Plasmakreatinins als Test des Glomerulusfiltrates

Schirmeister, J; Willmann, Hildegard; Kiefer, H.

doi:10.1007/978-3-642-96030-7_106

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…Blood urea nitrogen was measured colorimetrically at 578 nm according to the previous method of Chaney and Marbach [48]. Serum creatinine was determined by measuring the colored complex formed by the reaction of creatinine with picrate in an alkaline medium colorimetrically at 520 nm according to the previous method by Schirmeister and his colleagues [49].…”

Section: Assessment Of Renal Function Markersmentioning

confidence: 99%

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Mahran

Hassan

2020

Oxidative Medicine and Cellular Longevity

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Background. Cisplatin (cis-diaminedichloroplatinum, CDDP) is a broad-spectrum antineoplastic agent. However, CDDP has been blamed for its nephrotoxicity, which is the main dose-limiting adverse effect. Ganoderma lucidum (GL), a medicinal mushroom, has antioxidant and inflammatory activities. Therefore, this study is aimed at finding out the potential nephroprotection of GL against CDDP-induced nephrotoxicity in rats and the possible molecular mechanisms including the EGFR downstream signaling, apoptosis, and autophagy. Methods. Rats were given GL (500 mg/kg) for 10 days and a single injection of CDDP (12 mg/kg, i.p). Results. Nephrotoxicity was evidenced by a significant increase in renal indices and oxidative stress markers. Additionally, CDDP showed a plethora of inflammatory and apoptotic responses as evidenced by a profound increase of HMGB-1, NF-κB, and caspase-3 expressions, whereas administration of GL significantly improved all these indices as well as the histopathological insults. Renal expression of EGFR showed a similar trend after GL administration. Furthermore, activation of autophagy protein, LC3 II, was found to be involved in GL-mediated nephroprotection correlated with the downregulation of apoptotic signaling, caspase-3 and terminal deoxynucleotidyl transferase (TDT) renal expressions. Conclusion. These results suggest that GL might have improved CDDP-induced nephrotoxicity through antioxidant, anti-inflammatory, and autophagy-mediated apoptosis mechanisms and that inhibition of EGFR signaling might be involved in nephroprotection.

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Section: Assessment Of Renal Function Markersmentioning

confidence: 99%

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Mahran

Hassan

2020

Oxidative Medicine and Cellular Longevity

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“…Liver function tests, including liver enzymes (Alanine transaminase (ALT), Aspartate transaminase (AST) [44]) and gamma glutamyl transferase (GGT) [45], lipid profile (Total cholesterol (TC) [46], High density lipoprotein cholesterol (HDL) [47] and Triglycerides (TG) [48]) and total proteins [49] were determined using bio-diagnostic kits (Egy-Chem). [50] and creatinine [51] in serum were done using bio-diagnostic kits (Egy-Chem).…”

Section: Determination Of Liver Function Testsmentioning

confidence: 99%

Protective Effect of Camel Milk and Ginkgo biloba Extract Against Alloxan-Induced Diabetes in Rats

Hassan¹,

Emam²

2012

J Diabetes Metab

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Diabetes Mellitus is one of the most important health problems worldwide, indicating high prevalence and mortality. In recent years, Ginkgo biloba extract has become a subject of interest because of its beneficial effects on human health, also camel milk has a good nutritive value, in addition to its antigenotoxic and anticytotoxic effects. Therefore the purpose of the present study was to investigate the protective and curative effects of camel milk and Ginkgo biloba extract against alloxan-induced diabetes in rats.Rats were either pre-treated with camel milk, Ginkgo biloba extract or both, for 10 days before alloxan administration, or treated with both camel milk and Ginkgo biloba extract after induction of diabetes using alloxan.Pre-treatment of rats with either camel milk or Ginkgo biloba extract significantly prevented the alloxan-induced elevation of blood glucose levels. The combination of camel milk and Ginkgo biloba extract before and after induction of diabetes prevented and improved blood glucose levels respectively.

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“…The activities of alanine aminotransferase (ALT) (Catalog # AL 10 31 (45)), aspartate aminotransferase (AST) (Catalog # AS 10 61 (45)), and total bilirubin (Catalog # BR 1111) kits were purchased from Biodiagnostic (Dokki, Giza, Egypt), according to the manufacturers' guidelines (Mullon and Langer 1987;Reitman and Frankel 1957) The levels of urea (Catalog # UR 21 10) and creatinine (Catalog # CR 12 50) in the serum were estimated using commercial kits purchased from Biodiagnostic (29 Tahreer St., Dokki, Giza, Egypt). They were used according to manufacturers' guidelines (Fawcett and Scott 1960;Schirmeister et al, 1964).…”

Section: Serum Biochemical Analysismentioning

confidence: 99%

Protective Role of Concanavalin-A and/or IL-27 Against Adverse Effects of Cyclophosphamide on Hematological and Biochemical Parameters in Tumor-Bearing Mice

Elbeshlawy

Hamada²,

Goda³

et al. 2022

Damanhour Journal of Veterinary Sciences

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Cyclophosphamide (CTX) is a chemotherapeutic drug used to treat mammary gland tumors. Despite its cytotoxic effect on cancer cells, it causes harm to hepatic and renal tissues, ranging from mild infiltration to necrosis and finally cytolysis, depending on the dosage and duration of treatment. It also suppresses bone marrow, resulting in leukopenia, anemia, and thrombocytopenia. This study aimed to evaluate the protective effects of concanavalin A (con-A) and IL-27 conditioned immune therapeutics on Ehrlich ascites carcinoma (EAC) tumor-bearing mice treated with CTX. To achieve this, naive splenocyte cells were activated in vitro for 3 days with the T cell mitogen concanavalin A (Con-A; 5 µg/mL) and/or IL-27 (10; ng/mL). After a single i/p injection of CTX (4 mg/mouse), they were adoptively transferred into (EAC) tumor-bearing mice. After tumor implantation, hematological analysis, liver function, and kidney function were evaluated. According to the findings, the CTX-treated group had significantly lower total leucocyte count, lymphocytes, neutrophils, hematocrit, and RBCs than the control group. Interestingly, Con-A + IL-27 normalized the total leucocytes' count, especially lymphocytes and neutrophils. When Con-A + IL-27 was compared to CTX, there was a significant increase in hematocrit and platelet count. AST, ALT, bilirubin, creatinine, and urea levels were not significantly different between normal and Con-A + IL-27, but CTX significantly increased AST compared to normal. According to the findings, adoptive transfer of Con-A + IL-27 conditioned splenocyte cells into lymphopenic hosts restored hematological and biochemical parameters and recovery from chemotherapy-induced lymphopenia.

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Kritische Beurteilung des Plasmakreatinins als Test des Glomerulusfiltrates

Cited by 7 publications

References 5 publications

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Ganoderma lucidum Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis

Protective Effect of Camel Milk and Ginkgo biloba Extract Against Alloxan-Induced Diabetes in Rats

Protective Role of Concanavalin-A and/or IL-27 Against Adverse Effects of Cyclophosphamide on Hematological and Biochemical Parameters in Tumor-Bearing Mice

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