Kristallisierte Fucosido‐lactose

Kühn, Richard; Baer, Hans H.; Gauhe, Adeline

doi:10.1002/cber.19560891105

Cited by 56 publications

(21 citation statements)

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“…The first report of a type VI antigen structure from human sources was achieved in 1956 by Kuhn and co-workers, who isolated the H type VI antigen as the free oligosaccharide in appreciable quantities from human milk. 11 Subsequently, a type VI antigen from tissue samples was reported by Briemer and co-workers in 1982. 12 This glycolipid, named A-4 by Briemer, contained what was in the future termed the A type VI antigen, linked to ceramide.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of ABO histo-blood group type I and II antigens

Meloncelli

Lowary

2010

Carbohydrate Research

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Section: Introductionmentioning

confidence: 99%

Synthesis of ABO histo-blood group type I and II antigens

Meloncelli

Lowary

2010

Carbohydrate Research

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“…This indicates that in glycopeptide 4 the N-acetylneuraminic acid was linked to the C-3 hydroxyl group of the D-galactose residue that was terminal in glycopeptide 1. This type of linkage has been demonstrated in sialolactose (Kuhn, 1958). Since only 1 residue of D-galactose could be released enzymically the oigosaccharide units appear to be unbranched, and the terxninal D-galactose to be linked to acetamidohexose.…”

Section: Monosaccharide 6-deoxy-l-galactosementioning

confidence: 72%

Investigations on the oligosaccharide units of an A myeloma globulin

Dawson

Clamp

1968

Biochemical Journal

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The carbohydrate content of an A myeloma globulin was investigated. The carbohydrate content was found to be unchanged when the protein was isolated from the patient over a period of 18 months. The various polymeric forms of the protein contained similar proportions of carbohydrate. The A myeloma globulin contained approx. 2 residues of 6-deoxy-l-galactose (l-fucose), 14-15 of d-mannose, 12-13 of d-galactose, 12-13 of 2-acetamido-2-deoxy-d-glucose (N-acetyl-d-glucosamine), 6 of 2-acetamido-2-deoxy-d-galactose (N-acetyl-d-galactosamine) and 5 of N-acetylneuraminic acid (sialic acid), and these were distributed between six oligosaccharide units all of which were present on the heavy polypeptide chains. The oligosaccharide units showed two kinds of heterogeneity, which have been termed central and peripheral. Central heterogeneity was shown by the presence of three completely different core units, which had the following compositions: (1) 3 residues of d-galactose and 3 of 2-acetamido-2-deoxy-d-galactose, joined to protein by an O-glycosidic linkage between acetamidohexose and serine; (2) 3 residues of d-mannose, 2 of d-galactose and 3 of 2-acetamido-2-deoxy-d-glucose, joined to protein by an N-glycosidic linkage between acetamidohexose and aspartic acid; (3) 4 residues of d-mannose and 3 of 2-acetamido-2-deoxy-d-glucose with a linkage similar to that in (2). The core oligosaccharide units showed peripheral heterogeneity in the attachment of 6-deoxy-l-galactose, 2-acetamido-2-deoxy-d-glucose and N-acetylneuraminic acid. Tentative structures are proposed for these various types of oligosaccharide unit. Glycopeptides were isolated in which the sialic acid content exceeded that of d-galactose. Explanations are given for the electrophoretic mobility and staining characteristics of the various glycopeptides.

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“…In the previous papers,S,8) we presumed the structure of the unsaturated compound to be 2-acetamido-l,4-anhydro-2-deoxy-5,6-0 -is 0 propyIidene-Darabino-hex-l-enitol (2). Recently, Beau et ale have reported 9 ) that an alkaline treatment of 2-acetamido-2-deoxy-3,4 : 5,6-di-0-isopropylidene-aldehydo-D-glucose gave ·2-acetamido-2,3 -dideoxy-5,6-O-isopropylidene-ex-Derythro-hex-2-enofuranose (1). Therefore, in this paper, we have reinvestigated the unsaturated compound described above and examined the behavior of some 2-acetamido-2-deoxy-furanoses in the presence of alkaline ion-exchange resin.…”

Section: )mentioning

confidence: 99%