Korean version of the diagnostic interview for genetic studies: Validity and reliability

Joo, Eun Jeong; Joo, Yung Hyup; Hong, Jin-Pyo; Hwang, Suntae; Maeng, So-Jin; Han, Jin‐Hee; Yang, Byung-Hwan; Lee, Yu-Sang; Kim, Yong Sik

doi:10.1016/j.comppsych.2004.02.007

Cited by 62 publications

(53 citation statements)

References 8 publications

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“…This result is in concordance with several previous reports [2,15,[23][24][25][26][27][28][29][30] , although in one study just a fair interrater reliability value has been detected [17] .…”

Section: Discussionsupporting

confidence: 93%

“…In one study [17] , the diagnosis of schizoaffective disorder was associated with a low interrater reliability in both DSM-III-R and ICD-10. The results of another study [2] were contradictory in relation to ours: a high kappa value in ICD-10, and a low one in DSM-III-R. Other studies found a high [28] and a reasonable [24] interrater reliability in DSM-IV. In another study [29] , the diagnosis of schizoaffective disorder was associated with a reasonable interrater reliability in ICD-10.…”

Section: Discussioncontrasting

confidence: 86%

“…Three studies reported interrater reliability values within the range of the present study [17,23,24] . However, other studies found considerably higher values [2,13,15,21,[25][26][27][28][29][30] .…”

Section: Discussionsupporting

confidence: 67%

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The Diagnoses of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder and Unipolar Depression: Interrater Reliability and Congruence between DSM-IV and ICD-10

2009

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Background: The present study investigated the interrater reliability of the diagnoses of schizophrenia (SCH), schizoaffective disorder (SAD), bipolar disorder (BPD) and unipolar depression (UPD) according to both DSM-IV and ICD-10, as well as the diagnostic congruence between the two classificatory systems. Sampling and Methods: Using the Composite International Diagnostic Interview, two trained psychiatrists simultaneously evaluated 100 inpatients and independently assessed the psychiatric diagnoses. The Cohen’s kappa coefficient was employed to estimate interrater reliability and diagnostic congruence between DSM-IV and ICD-10. Results: SCH was more frequent according to ICD-10 than DSM-IV criteria. Considering both diagnostic systems, all the four nosological categories, but ICD-10 SAD and DSM-IV UPD, were associated with interrater reliability coefficients above 0.50. The coefficient of the diagnostic congruence between DSM-IV and ICD-10 was inferior to 0.50 only for SAD. BPD was associated with the highest degrees of both interrater reliability and diagnostic congruence. Conclusions: The lack of an item excluding the occurrence of an affective syndrome among ICD-10 diagnostic criteria for SCH can account for: the larger frequency of SCH according to ICD-10 than DSM-IV; the unsatisfactory interrater reliability for the diagnosis of ICD-10 SAD, and the low diagnostic congruence for SAD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 86%

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The Diagnoses of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder and Unipolar Depression: Interrater Reliability and Congruence between DSM-IV and ICD-10

2009

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“…All subjects were self-identified Koreans, and ethnic origin was further ascertained by confirming the ethnicity of three generations of the patients’ families. Trained psychiatrists examined all potential subjects using the Structured Clinical Interview for the fourth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) [30] and the Korean version of the Diagnostic Interview for Genetic Studies [31]. Only subjects with a minimum score of 18 on the 21-item Hamilton Depression Rating (HAMD-21) scale [32] entered the study.…”

Section: Methodsmentioning

confidence: 99%

Association between Serotonin Transporter-Linked Polymorphic Region and Escitalopram Antidepressant Treatment Response in Korean Patients with Major Depressive Disorder

Won¹,

Chang²,

Lee

et al. 2012

Neuropsychobiology

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Objective: Various studies have shown that short (s)/long (l) polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) might predict treatment outcome to selective serotonin reuptake inhibitors. The purpose of this study was to evaluate the association between 5-HTTLPR and clinical response to escitalopram treatment in Korean subjects with major depressive disorder. Methods: One hundred and fifteen Korean patients diagnosed with major depressive disorder were evaluated during 8 weeks of escitalopram treatment at a dose of 5–20 mg/day. Patients were genotyped for 5-HTTLPR using polymerase chain reaction. Clinical symptoms were evaluated by the 21-item Hamilton Depression Rating (HAMD-21) scale during the 8 weeks of treatment. Results: Therapeutic response to antidepressant escitalopram was better in s allele carriers (ss, sl) than in l allele homozygotes (ll) at 8 weeks of treatment (OR = 6.24, p = 0.026). The proportion of s allele carriers in responders was higher than that in non-responders (96.6 vs. 85.7%). The percentile decline in HAMD-21 in s allele carriers (59.86 ± 3.23%) was larger than that in HAMD-21 in l allele homozygotes (43.13 ± 11.49%; p = 0.029). However, 5-HTTLPR genotypes were not significantly associated with remission (p > 0.05). Conclusions: Our results show that treatment response to escitalopram at 8 weeks was moderated by 5-HTTLPR, with better response rates for s allele carriers than for l allele homozygotes. Although the role of 5-HTTLPR as a definite predictor of selective serotonin reuptake inhibitor treatment response cannot be confirmed from current results, they do suggest a trend for better response in s allele carriers.

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“…Consensus diagnostic meetings of more than two psychiatrists were held regularly to evaluate the participants' final diagnoses. Most of the patients (196) were comprehensively interviewed by trained nurses using the Korean-translated version of the Diagnostic Interview for Genetic Studies (DIGS) (Nurnberger et al, 1994;Joo et al, 2004). Exclusion criteria based on additional information garnered from medical records included subjects younger than 18, a history of any kind of organic brain abnormality, an alcohol problem, drug abuse, or other physical conditions presenting with psychiatric symptoms.…”

Section: Subjectsmentioning

confidence: 99%

Associations betweenDRDs and schizophrenia in a Korean population: multi-stage association analyses

Lee

Joo

et al. 2011

Exp Mol Med

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Abbreviations: DIGS, diagnostic interview for genetic studies; DRDs, dopamine receptor genes; DSM-IV, diagnostic and statistical manual of mental disorders-4th edition; HWE, Hardy-Weinberg equilibrium; LD, linkage disequilibrium; MALDI-TOF MS, matrixassisted laser desorption-time-of-flight mass spectrometry; SNP, single nucleotide polymorphism; VNTR, variable number of tandem repeats AbstractThe dysregulation of the dopaminergic system has been implicated in the pathophysiology of major psychosis, including schizophrenia, with dopamine receptor genes (DRDs) presently targeted as the most promising candidate genes. We investigated DRD1-5 for association with schizophrenia using a multi-stage approach in a Korean sample. One hundred forty-two SNPs in DRD1-5 were selected from the dbSNP, and the associations of each SNP were then screened and typed by MALDI-TOF mass spectrometry using pooled DNA samples from 150 patients with major psychosis and 150 controls. Each of the suggested SNPs was then genotyped and tested for an association within the individual samples comprising each pool. Finally, the positively associated SNPs were genotyped in an extended sample of 270 patients with schizophrenia and 350 controls. Among the 142 SNPs, 88 (62%) SNPs in our Korean population were polymorphic. At the pooling stage, 10 SNPs (DRD1: 2, DRD2: 3, and DRD4: 5) were identified (P ＜ 0.05). SNPs rs1799914 of DRD1 (P = 0.046) and rs752306 of DRD4 (P = 0.017) had significantly different allele frequencies in the individually genotyped samples comprising the pool. In the final stage, with the extended sample, the suggestive association of DRD4 with rs752306 was lost, but the association of DRD1 with rs1799914 gained greater significance (P = 0.017). In these large-scale multi-stage analyses, we were able to find a possible association between DRD1 and schizophrenia. These findings suggested the potential contribution of a multi-step strategy for finding genes related to schizophrenia.

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Korean version of the diagnostic interview for genetic studies: Validity and reliability

Cited by 62 publications

References 8 publications

The Diagnoses of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder and Unipolar Depression: Interrater Reliability and Congruence between DSM-IV and ICD-10

The Diagnoses of Schizophrenia, Schizoaffective Disorder, Bipolar Disorder and Unipolar Depression: Interrater Reliability and Congruence between DSM-IV and ICD-10

Association between Serotonin Transporter-Linked Polymorphic Region and Escitalopram Antidepressant Treatment Response in Korean Patients with Major Depressive Disorder

Associations betweenDRDs and schizophrenia in a Korean population: multi-stage association analyses

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