Korean ginseng extract attenuates reserpine-induced orofacial dyskinesia and improves cognitive dysfunction in rats

Sanghavi, Chetankumar R.; Barhate, S. A.; Mahajan, Manoj; Mohan, Mahalaxmi; Kasture, Sanjay

doi:10.1080/14786410802583031

Cited by 14 publications

(3 citation statements)

References 23 publications

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“…The above findings showed significant motor impairment induced by reserpine, which is in line with several studies (44)(45)(46). However, we demonstrated the neuroprotective efficacy of the antioxidants (vitamins C and E) against this impairment.…”

Section: Discussionsupporting

confidence: 92%

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Danboyi¹,

Jimoh²,

lhassan³

et al. 2021

ABMS

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Background: The conventional treatments for Parkinson's disease, the most common movement disorder globally, have not been able to halt its progression hence, newer approaches targeting its pathogenesis are being explored. We investigated the effect of vitamins C and E (in combination) on reserpine-induced motor impairment in mice. Materials and Methods: Twenty-five mice were randomly grouped into five groups of five mice each. All the groups except group I (control), were given an alternate days injection of reserpine 0.1 mg/kg intraperitoneally. Groups III and IV were administered vitamin E 200 mg/kg/day (vitamin E group), and vitamin C 250 mg/kg/day (vitamin C group), respectively while group V (co-administered group) was given both vitamins orally. Group II (reserpine group) received nothing in addition to reserpine. All drugs were given concurrently for 28 days. The neurobehavioral assessment was performed using beam walking and open field tasks. Results were presented as mean±SEM and statistical significance was placed at p < 0.05. Results: There were significant increases in a number of foot slips (3.60±0.68; p = 0.002) and the time spent in reaching the 'safe' platform (36.60±5.78 s; p = 0.0001) in the reserpine group, both of which were markedly reduced in the co-administered group (0.25±0.25 and 3.00±0.41s respectively). The co-administered group demonstrated a marked decrease in transfer latency (10.33±1.45s; p = 0.005) and crossed significantly more lines (56.00±13.53 lines; p = 0.0001) in the open field compared to the reserpine group (214.00±64.16s and 4.3±1.67 lines respectively). Conclusion: Co-administration of vitamins C and E protected against motor impairment induced by reserpine in mice.

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Section: Discussionsupporting

confidence: 92%

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Danboyi¹,

Jimoh²,

lhassan³

et al. 2021

ABMS

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“…Reserpine, in the dose range of 1–10 mg/kg, is able to induce decreases in catalase, superoxide dismutase, total content of reduced glutathione, and ATP. Similarly, it increases glutathione peroxidase activity, oxidized glutathione, lipid peroxidation, nitric oxide (NO), and iron ; for a summary, see Table ). Overall, there is an increase in oxidative damage.…”

Section: Molecular and Neurochemical Features Of The Reserpine Modelmentioning

confidence: 99%

Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson's Disease: New Perspectives to a Long‐Standing Model

et al. 2015

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The administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson's disease (PD). The reserpine model was critical to the understanding of the role of monoamine system in the regulation of motor and affective disorders, as well as the efficacy of current PD treatments, such as L-DOPA and dopamine agonists. Nevertheless, with the introduction of toxin-induced and genetic models of PD, reserpine became underused. The main rationale to this drawback was the supposed absence of reserpine construct validity with PD. Here, we highlight classical and recent experimental findings that support the face, pharmacological, and construct validity of reserpine PD model and reason against the current rationale for its underuse. We also aim to shed a new perspective upon the model by discussing the main challenges and potentials for the reserpine model of PD.

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“…[22,23] Based on this "free radical hypothesis" associated with motor and cognitive impairment, reserpine has been reported to induced OS related to neuronal cell death in several in vivo studies. [24] Furthermore, cognitive and motor impairment brought about by certain D2 receptor blocker neuroleptics like haloperidol is utilized as a preclinical model to induced extra-pyramidal symptoms (EPS) to screen anti-Parkinson's potential of the drug. [25] The present study was aimed to investigate whether ALP-SENF attenuates the OS-associated motor and cognitive function induced by reserpine and EPS induced by haloperidol in rats or not.…”

mentioning

confidence: 99%

Neuroprotective effect of α‐pinene self‐emulsifying nanoformulation against 6‐OHDA induced neurotoxicity on human SH‐SY5Y cells and its in vivo validation for anti‐Parkinson's effect

Srivastava

Choudhury

Dev

et al. 2021

J Biochem & Molecular Tox

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Oxidative stress (OS) is involved in the multifaceted pathogenic paradigm of neurodegenerative diseases like Parkinson's disease (PD). Monoterpenes like α-pinene (ALP) is considered to be a therapeutically potent antioxidant agent able to attenuate and scavenge various reactive oxygen species and reactive nitrogen species. The present study aimed to evaluate the in vitro and in vivo neuroprotective effect of αpinene self-emulsifying nanoformulation (ALP-SENF) for PD. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was done to evaluate the neurotoxic dose of the ALP-SENF; however, the neuroprotective effect was assessed by 6-hydroxydopamine (6-OHDA) induced neurotoxicity model on SH-SY5Y taking NAC (N-acetyl-L-cysteine) as standard. The in vivo anti-Parkinson's activity of the ALP-SENF was compared with that of the plain ALP suspension by using reserpine antagonism and haloperidol-induced Parkinsonism model in rats. Various behavioral tests and biochemical antioxidant enzymes were estimated. The in vitro results revealed that treatment with ALP-SENF at a concentration of 100 and 200 µM was found to show significant neuronal SH-SY5Y cell viability against 50 µM 6-OHDA. ALP-SENF treated animals have seen significant neurobehavioral improvement. Furthermore, the levels of antioxidative enzymes in biochemical test reveals a marked enhancement in the expression of antioxidant enzymes that significantly attenuated the OS induced neurodegeneration. Due to the mechanisms of their antioxidant action, it was probably due to the scavenging of free radicals and the expression of antioxidant enzymes. It also improved neurobehavioral changes induced by reserpine and haloperidol.

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Korean ginseng extract attenuates reserpine-induced orofacial dyskinesia and improves cognitive dysfunction in rats

Cited by 14 publications

References 23 publications

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Co-Administration of Vitamins C and E is Protective against Reserpine-induced Motor Impairment in Mice.

Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson's Disease: New Perspectives to a Long‐Standing Model

Neuroprotective effect of α‐pinene self‐emulsifying nanoformulation against 6‐OHDA induced neurotoxicity on human SH‐SY5Y cells and its in vivo validation for anti‐Parkinson's effect

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