Kombucha ameliorates LPS-induced sepsis in a mouse model

Wang, Peng-Hui; Feng, Zhen; Sang, Xiao; Chen, Wenzhi; Zhang, Xiaoni; Xiao, Jianbin; Chen, Youqiang; Chen, Qi; Yang, Mo; Su, Jingqian

doi:10.1039/d1fo01839f

Cited by 44 publications

(45 citation statements)

References 52 publications

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“…Black tea kombucha was associated with a decreased abundance of Allobaculum, Turicibacter, and Clostridium genera and an increase in Mucispirillum, a genus positively correlated to circulating leptin, which is a hormone involved in the regulation of appetite and food intake [22]. In another study, green tea kombucha supplementation was associated with an increase in alpha-diversity as well as favored the growth of bacteria involved in butyrate production [23]. Additionally, a recent systematic review has pointed out that kombucha consumption was able to reduce intestinal dysbiosis in vivo, being suggested as a potential alternative for the control and treatment of obesity and its associated comorbidities [24].…”

Section: Introductionmentioning

confidence: 94%

“…Thus, we aimed to investigate the effects of regular kombucha consumption on the gut microbiota and on outcomes related to the intestinal health of Wistar rats fed a high-fat high-fructose diet. Based on the chemical and microbiological composition of the beverages, as well as on previous studies [22,23], we hypothesized that green and black tea kombuchas would be able to modulate the gut microbiota and improve the intestinal health of those animals.…”

Section: Introductionmentioning

confidence: 99%

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Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet

et al. 2022

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The Western diet can negatively affect the gut microbiota and is associated with metabolic disorders. Kombucha, a tea fermented by a symbiotic culture of bacteria and yeast (SCOBY), is known for its bioactive properties and has become popular in the last years. In this study, we evaluated the effects of regular kombucha consumption on the gut microbiota and on outcomes related to the intestinal health of Wistar rats fed a high-fat high-fructose diet. After eight weeks receiving a standard diet (AIN-93M) (n = 10) or a high-fat and high-fructose diet (HFHF) (n = 30) to induce metabolic disorders, the animals were subdivided into four groups: AIN-93M (n = 10); HFHF (n = 10); GTK (HFHF + green tea kombucha (n = 10); and BTK (HFHF + black tea kombucha; n = 10) for 10 weeks. Although body composition did not differ among the groups, the HFHF diet was associated with metabolic alterations, and stimulated the growth of gram-negative bacteria such as Proteobacteria and Bacteroides. Kombucha ingestion could somewhat modulate the gut microbiota, attenuating the effects of a Western diet by increasing propionate production and favoring the growth of beneficial bacteria, such as Adlercreutzia in the GTK group. Our results suggest that regular kombucha consumption may be beneficial to intestinal health, which can be mostly attributed to its high content and diversity of phenolic compounds.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet

et al. 2022

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“…These data of traditional medicine were confirmed by laboratory tests [16] and in the former U.S.S.R. clinical settings [6]. In particular, the consumption of kombucha culture by LPS-treated or the type-2-diabetes-mice promoted the diversity of their gut microbiota, activating the SCFA-producing bacteria and providing anti-inflammatory effects [92,96]. The recovery of normal gut microbiota was also observed in mice with the nonalcoholic fatty liver disease treated with kombucha, i.e., an increase in the proportion of Bacteroidetes and Lactobacillus and a decrease of pathogenic bacteria caused this disease [48].…”

Section: Kombucha As a Synbiotic And Edible Vaccinementioning

confidence: 76%

The Conceptual Approach to the Use of Postbiotics Based on Bacterial Membrane Nanovesicles for Prophylaxis of Astronauts’ Health Disorders

ORLOVSKA¹,

PODOLICH²,

KUKHARENKO³

et al. 2022

Kosm. nauka tehnol.

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The functional fermented foods containing live microorganisms and their components are necessary for the normal functioning of the human body as normal gut microbiota needs fuel from external microbial organisms and their nanostructures — membrane vesicles (MVs), excreting outside. The сoncept that MVs may contribute to astronauts’ health probably to the same extent as their parental microbial cells do and be a temporary substitute for living microbial cells until we know more about the behavior of microbes in the space environment. The advantage of MVs is that they are not alive and cannot be changed under unfavorable conditions as microbial organisms may be. As the model, we selected MVs of a robust to environmental factors kombucha multimicrobial culture (KMC), known for its health-promoting characteristics for humans. We exposed KMC on the International Space Station in a hybrid space/Mars-like environment for an initial proof-of-concept stage. In the exposure study, KMC has survived a long-term period in harsh conditions, and the MVs generated by post-flight kombucha community members did not acquire toxicity, despite the changed membrane composition in the environment imitated conditions on the Mars surface. This observation, together with our KMC metagenomic and comparative genomic analyses of the dominant KMC bacterium Komagataeibacter oboediens, showed that the ground reference sample and spaceexposed ones were similar in topology and maintained their stability. In the next stage, we assessed the fitness, safety, and biodistribution of MVs of post-flight K. oboediens and showed that they were altered, but the modifications in membrane structure did not result in toxicity acquisition. Our proof-of-concept strategy is discussed in this review in line with the literature.

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“…DNA was extracted from the cecal contents using the Magnetic Soil and Stool DNA Kit (Tiangen biotech Co., Ltd., Beijing, China) according to the manutacturer's instructions. The full-length of the bacterial 16S rRNA gene was amplified using the following primer pairs: 27F (5′-AGRGTTTGATYNTGGCTCAG-3′) and 1492R (5′-TASGGHTACCTTGTTASGACTT-3′) ( 27 ). Thermal cycling consisted of the following condition: 95°C for 2 min; 25 cycles of 98°C for 10 s, 55°C for 30 s, 72°C for 1 min 30 s; and a final extension period at 72°C for 7 min.…”

Section: Methodsmentioning

confidence: 99%

Coix Seed-Based Milk Fermented With Limosilactobacillus reuteri Improves Lipid Metabolism and Gut Microbiota in Mice Fed With a High-Fat Diet

et al. 2022

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The aim of this study was to investigate the effects of coix seed-based milk (CSM) fermented with Limosilactobacillus reuteri (L. reuteri) on dyslipidemia and the composition of the intestinal microbiota in high fat diet (HFD)-fed mice. Changes in the body weight, serum lipid levels, activities of hepatic oxidative stress factors, expression of lipid-related genes, and composition of the intestinal microbiota of HFD-fed mice after supplementation with CSM were determined. The results showed that intake of CSM reduced the body weight gain as well as serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels, and increased the high-density lipoprotein cholesterol (HDL-C) levels in the mice. Meanwhile, supplementation with CSM could relieve liver oxidative stress, down-regulate the expression of genes related to lipid synthesis, and prevent liver fat accumulation in mice fed with HFD. The 16S rRNA sequencing of the intestinal microbiota showed that CSM regulated the gut microbiota community structure at different taxonomic levels, and reversed gut dysbiosis induced by HFD. The relative abundance of Muribaculaceae, Lachnospiraceae, Dubosiella and Akkermansia which are negatively correlated with blood lipid levels were significantly increased by the intervention of CSM, while the relative abundance of Desulfovibrionaceae, Ruminococca-ceae_UCG-014, Psychrobacter, and Staphylococcus which have positive correlation with blood lipid levels were significantly decreased. These results indicated that CSM might serve as a novel and promising dietary supplement for ameliorating hyperlipidemia and intestinal microbiota disorders caused by HFDs.

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Kombucha ameliorates LPS-induced sepsis in a mouse model

Abstract: As a popular traditional fermented beverage, kombucha has been extensively studied for its health beneﬁts. However, the science behind the anti-inflammatory of kombucha has not been well conducted, and there...

Cited by 44 publications

References 52 publications

Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet

Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet

The Conceptual Approach to the Use of Postbiotics Based on Bacterial Membrane Nanovesicles for Prophylaxis of Astronauts’ Health Disorders

Coix Seed-Based Milk Fermented With Limosilactobacillus reuteri Improves Lipid Metabolism and Gut Microbiota in Mice Fed With a High-Fat Diet

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