Kolaviron, a biflavonoid fraction from <i>Garcinia kola</i>, protects against isoproterenol-induced injury by mitigating cardiac dysfunction and oxidative stress in rats

Adaramoye, Oluwatosin A.; Lawal, S. O. A.

doi:10.1515/jbcpp-2013-0139

Cited by 28 publications

(16 citation statements)

References 36 publications

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“…Damage to cardiac tissue induced by different β-adrenergic receptor agonist like isoprenaline increases the level of ALT, AST, and ALP enzymes [39]. Myocardial necrosis induced by ISO treatment increases ALT, AST and ALP activities are observed in plasma.…”

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Ulla

Mohamed

Sikder

et al. 2017

BMC Pharmacol Toxicol

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BackgroundThe objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.MethodsRats were divided into three groups namely Control group, ISO treated group and CoQ10 + ISO treated group, each consisting of 6 rats. The cardiac specific CK-MB, AST, ALT activity and other oxidative stress parameters were estimated in heart and kidneys. Additionally histological examination was also performed to visualize the inflammatory cells infiltration and fibrosis in both tissues.ResultsAdministration of ISO resulted in an increase in the heart-to-body weight (HW/BW) ratio and an also increased the serum CK-MB, AST and ALT enzyme activity. Serum levels of lipid peroxidation products, and oxidative stress markers showed significant increase in ISO-treated rats. Histopathological examination of heart tissue revealed focal areas of endocardium degeneration, mononuclear cells infiltration, fibrous tissue deposition, and increased thickness of the myocardium of left ventricle. Similar degeneration was also found in kidneys. Treatment with CoQ10 (100 mg/kg) significantly improved the oxidative stresses in ISO treated rats. Moreover, CoQ10 treatment prevented inflammatory cells infiltration and reduced fibrosis in ISO administered rats.ConclusionIn conclusion, our study provides evidence that CoQ10 may prevent the development of cardiac remodeling, and fibrosis in ISO administered rats.

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Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Ulla

Mohamed

Sikder

et al. 2017

BMC Pharmacol Toxicol

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“…In the midst of several cardiovascular diseases, ischaemic heart disease is the foremost cause of morbidity and mortality in both industrialized and developing countries and is envisaging, being the key and most common threat to human life by 2020 [1][2][3]. A number of means have been proposed to explicate the myocardial injury and hemodynamic dysfunction during myocardial infarction (MI).…”

Section: Introductionmentioning

confidence: 99%

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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Apigenin (AP) is a flavone in dietary flavonoids reported as strong antioxidant and elite modulator of PPARγ. The current study evaluated the consequence of AP in isoproterenol (ISO)-induced oxidative stress and myocardial infarction during β-adrenergic receptor stimulus in rats by persistent hemodynamic, biochemical and histopathological changes. Rats received AP (25, 50 and 75 mg/kg/day) or vehicle i.p. for 14 days and ISO (100 mg/kg, s.c.) on 13th and 14th days for initiation of cardiotoxicity. ISO-treated rats showed evidence of significant dwindle in systolic and diastolic arterial pressures, maximal positive rate of developed left ventricular pressure. In totting up, a noteworthy diminution in activities of creatine kinase-MB isoenzyme, reduced glutathione, superoxide dismutase, catalase and level along with rise in malondialdehyde content were observed. The shielding function of AP on isoproterenol-induced myocardial damage was observed by attenuating all the endogenous parameters and the membrane-bound enzymes. It was confirmed by histopathological examinations. The effect of AP at the doses of 50 and 75 mg/kg showed added apparent than at the dose of 25 mg/kg. Current study thus provides confirmation for protective effects of AP on myocardium in experimentally induced myocardial infarction.

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“…Its antioxidant and anti-inflammatory actions have been employed to protect against many pathological conditions (Adedara and Farombi 2012;Olaleye et al 2000). Its cardio protective (Adaramoye and Lawal 2015) and nephro-protective (Adedara et al 2015) actions have been reported. Gallic acid (Figure 1b) is an endogenous plant phenol that is found in many fruits, teas and wine (Ma et al 2003;Singh et al 2004).…”

Section: R a F Tmentioning

confidence: 99%

Protective effects of kolaviron and gallic acid against cobalt-chloride-induced cardiorenal dysfunction via suppression of oxidative stress and activation of the ERK signaling pathway

Akinrinde

Omobowale

Oyagbemi

et al. 2016

Can. J. Physiol. Pharmacol.

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Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements and blood doping in athletes and horses. We investigated the protective roles of Kolaviron, KV (a bi-flavonoid of Garcinia kola) and Gallic acid (GA) on cobalt chloride (CoCl 2 ) -induced cardio-renal damage in rats. CoCl 2 caused significant increases (p<0.05) in serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase (XO), urea, creatinine, malondialdehyde, H 2 O 2 , nitric oxide, as well as C-reactive protein expression, along with significant (p<0.05) reduction in cardiac and renal expression of extracellular signal regulated kinase (ERK) and the activities of superoxide dismutase, catalase and glutathione S-transferase.KV and GA prevented the toxic effects of CoCl 2 by stimulating ERK expression and reversing Co-induced biochemical changes. Administration of CoCl 2 alone did not significantly alter ECG patterns in the rats, although co-treatment with KV (200 mg/kg) produced QT-segment prolongation and also appeared to potentiate Co-hypotension. Histopathology of the heart and kidneys of rats treated with KV and GA confirmed the biochemical data. Kolaviron and Gallic acid thus protected against cardiac and renal damage in cobalt-intoxication via antioxidant and/or cell survival mechanisms, possibly involving ERK activation.

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Kolaviron, a biflavonoid fraction from Garcinia kola, protects against isoproterenol-induced injury by mitigating cardiac dysfunction and oxidative stress in rats

Abstract: KV protects against ISO-induced cardiotoxicity in vivo, suggesting its usefulness as a possible chemoprophylactic agent against cardiotoxic drugs.

Cited by 28 publications

References 36 publications

Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

Protective effects of kolaviron and gallic acid against cobalt-chloride-induced cardiorenal dysfunction via suppression of oxidative stress and activation of the ERK signaling pathway

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