Kolanut (Kola nitida) Enhances Antidiuretic Activity in Young Dehydrated Subjects

Obika, L. F. O.; Babatunde, E. O.; Akoni, F. A.; Adeeko, Adedayo; Nsaho, J.; Reza, Hamedinia Mohammad; Williams, Shirley

doi:10.1002/(sici)1099-1573(199611)10:7<563::aid-ptr896>3.0.co;2-x

Cited by 6 publications

(5 citation statements)

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“…The baseline TP reported in these studies agrees with earlier reports of Obika and Mowoe, (1997), of 4.1 ± 0.05 cm and Obika et al, (1996) of 2.5 ± 0.5 cm. in young healthy non dehydrated subjects.…”

Section: Discussionsupporting

confidence: 92%

Thirst perception in dehydrated sickle cell disease patients in steady state

Ozoene¹,

Enosolease²,

Ajayi³

et al. 2010

Nig. J. Phys Sci

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Summary:Liberal fluid intake is one of the key management strategies in sickle cell anaemia (SCA) patients in steady state, but less work has been done on the desire of patients to drink water. Using the Visual Analogue Scale we studied thirst perception (TP) in 20 euhydrated SCA patients and 28 control (HbA) subjects, as well as during dehydration in 13 SCA patients and 9 HbA subjects. Serum and urine samples were collected and analyzed for Na, K ions, creatinine concentrations and haematocrit and specific gravity of urine were determined. During euhydration, TP was significantly [P<0.05] higher in male SCA patients compared to the HbA subjects. In females, TP in SCA patient was not statistically significant compared with HbA subjects. After 13 hours of dehydration, TP was significantly [P<0.05] reduced in female. While dehydration increased TP in HbA subjects, it reduced TP in SCA patients. Fluid intakes after dehydration in SCA patients were not significantly different from the control HbA subjects in both male and female. It can be concluded that female SCA patients do not have normal response to dehydration with regards to TP after a period of dehydration. Since dehydration stimulates the release of vasoactive hormones like vasopressin, this may explain why female patients are less prone to crisis than their male counterparts.

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Section: Discussionsupporting

confidence: 92%

Thirst perception in dehydrated sickle cell disease patients in steady state

Ozoene¹,

Enosolease²,

Ajayi³

et al. 2010

Nig. J. Phys Sci

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“…It has been cultivated in other parts of the World such as India, Australia, Malaysia, Trinidad, Jamaica, Brazil, and Hawaii [ 17 ]. Kola nut tree contains compounds that have antimicrobial [ 18 , 19 ], anti-inflammatory [ 20 ], antidiuretic [ 21 ], antidiabetic [ 22 ], antioxidative [ 23 ] and anticancer [ 24 ] activities. The plant has also been used to treat cardiovascular disease, whooping cough and asthma [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional titanium dioxide nanoparticles biofabricated via phytosynthetic route using extracts of Cola nitida: antimicrobial, dye degradation, antioxidant and anticoagulant activities

Akinola

Lateef

Asafa

et al. 2020

Heliyon

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First study of phytosynthesis of TiO 2 NPs using the leaf (KL), pod (KP), seed (KS) and seed shell (KSS) extracts of kola nut tree ( Cola nitida ) is herein reported. The TiO 2 NPs were characterized and evaluated for their antimicrobial, dye degradation, antioxidant and anticoagulant activities. The nearly spherical-shaped particles had λmax of 272.5–275.0 nm with size range of 25.00–191.41 nm. FTIR analysis displayed prominent peaks at 3446.79, 1639.49 and 1382.96 cm −1 , indicating the involvement of phenolic compounds and proteins in the phytosynthesis of TiO 2 NPs. Both SAED and XRD showed bioformation of crystalline anatase TiO 2 NPs which inhibited multidrug-drug resistant bacteria and toxigenic fungi. The catalytic activities of the particles were profound, with degradation of malachite green by 83.48–86.28 % without exposure to UV-irradiation, scavenging of DPPH and H 2 O 2 by 51.19–60.08 %, and 78.45–99.23 % respectively. The particles as well prevented the coagulation of human blood. In addition to the antimicrobial and dye-degrading activities, we report for the first time the H 2 O 2 scavenging and anticoagulant activities of TiO 2 NPs, showing that the particles can be useful for catalytic and biomedical applications.

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“…Burrell et al, (1991) reported a value of thirst perception (TP) of 1.3 ± 0.4cm and 1.5 ± 0.4cm in experimental and control male subjects respectively as 'not thirsty'. Obika et al, (1996) in their work on kolanut activity in young dehydrated subjects reported thirst rating of 2.5 ± 0.5cm in control young subjects as 'not thirsty. ' Figaro and Mack (1997) also in their work in dehydrated humans showed ratings of perceived thirst and mouth dryness of 1.5 ± 0.6cm and 0.9 ± 0.2cm as 'not thirsty' and 'not dry' respectively in control subjects.…”

Section: Discussionmentioning

confidence: 96%

Thirst perception and dryness of mouth in healthy young adults nigerians

Igbokwe¹,

Obika²

2010

African Journal of Biomedical Research

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This study examined the threshold for thirst perception (TP) using the visual analogue scale (VAS). Thirst perception (TP) and dryness of mouth (DM) were studied in normal subjects, (n = 137; 78 males of height, 1.72 ± 0.01, age, 23 ± 0.26, body mass index, 21.11 ± 0.29, and 59 females of height, 1.65 ± 0.01, age, 21 ± 0.23, body mass index, 21.0 ± 0.27). The results showed that (i) TP and DM in males, (1.21 ± 0.15 cm and 1.14 ± 0.16cm respectively) and in females, (1.10 ± 0.16cm and 1.04 ± 0.17cm respectively) were similar. (ii) The relationship, Thirst (cm) = 0.75 (plasma arginine vasopressin ± 1.2) exists and has a mean of not thirsty of 1.2cm at the lower end of the scale. (iii) The plasma osmolality of 281mOsm/kg cannot be the threshold for TP and the plasma osmolality of 285mOsm/kg or 284.3mOsm/kg cannot be the threshold for plasma arginine vasopressin secretion but rather the mean of the lower set point of the scales for TP and plasma arginine vasopressin [P AVP ] secretion. (iv) The threshold for TP using the VAS is between 1.50 -1.575cm markings, and plasma osmolality of 286.0 -286.25 mOsm/kg. P AVP of 0.4 -0.5 pmol/l being the sensitivity of the osmoregulatory unit.

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Kolanut (Kola nitida) Enhances Antidiuretic Activity in Young Dehydrated Subjects

Cited by 6 publications

References 0 publications

Thirst perception in dehydrated sickle cell disease patients in steady state

Thirst perception in dehydrated sickle cell disease patients in steady state

Multifunctional titanium dioxide nanoparticles biofabricated via phytosynthetic route using extracts of Cola nitida: antimicrobial, dye degradation, antioxidant and anticoagulant activities

Thirst perception and dryness of mouth in healthy young adults nigerians

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