Kokosanolide D: A New Tetranortriterpenoid from Fruit Peels of Lansium domesticum Corr. cv Kokossan

Fauzi, Fawwaz M.; Meilanie, Sylvia Rachmawati; Zulfikar, Zulfikar; Farabi, Kindi; Herlina, Tati; Anshori, Jamaludin Al; Mayanti, Tri

doi:10.3390/m1232

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…The structures of compounds 1-4 are shown in Figure 1 below. Compounds such as sesquiterpenoids, steroids, and limonoids have also been isolated [7,45]. Compounds 1-4 showed no antibacterial or antifungal activity, which is consistent with the results of Ragasa et al [10].…”

Section: Discussionsupporting

confidence: 84%

Bioactivities Screening and Elucidation of Terpenoid from the Stembark Extracts of Lansium domesticum Corr. cv. Kokosan (Meliaceae)

et al. 2023

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Lansium domesticum Corr. (L. domesticum), Meliaceae, has an economical fruit found throughout the southeast and has been reported to be used in traditional medicine. Therefore, this study aims to investigate the antimicrobial and cytotoxic potential of four extracts from the stembark of L. domesticum Corr. cv. Kokossan and isolated four terpenoid compounds. Antimicrobial testing was performed on two fungi, namely Malassezia furfur and Candida albicans, and two bacteria, Staphylococcus epidermidis and Klebsiella pneumoniae. Furthermore, antimicrobial activity was determined using the minimum inhibitory concentration (MIC). All isolated extracts were also tested on MCF-7 breast cancer cells. The results showed that butanol and n-hexane extracts have antimicrobial potential against K. pneumoniae bacteria with MIC values of 7.8125 mg/mL and 62.5 mg/mL, respectively, as well as against the dandruff fungus M. furfur. In addition to the antimicrobial results, the anticancer test results also showed that n-hexane has the most interesting cytotoxic value of all extracts, with an IC50 of 42.95 µg/mL than extracts of ethyl acetate, ethanol, and butanol with respective IC50 values of 72.84; 74.50, and 12088.33 µg/mL. The n-hexane and n-butanol extracts have anticancer and antimicrobial potential. These extracts can be studied further for other bioactivity.

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Section: Discussionsupporting

confidence: 84%

Bioactivities Screening and Elucidation of Terpenoid from the Stembark Extracts of Lansium domesticum Corr. cv. Kokosan (Meliaceae)

et al. 2023

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“…This compound structurally resembled 47 , however, an H 2 O was added to the endocyclic double bond to provide the corresponding alcohol [ 76 ]. Whilst kokosanolide D ( 50 ) was obtained from the peels n-BuOH fraction elucidated using IR, NMR, and HRMS [ 78 ].…”

Section: Phytoconstituents Of L Domesticummentioning

confidence: 99%

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

2022

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Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines. Traditionally, it is utilized as a folk treatment for eye inflammation, ulcers, diarrhea, dysentery, fever, spasms, flatulence, worms, insect bites, scorpion stings, and malaria. Additionally, it is utilized as a mosquito repellent, skin moisturizer and whitening agent. Pharmacological research showed that the plant has a wide array of bioactivities, including antimalarial, antifeedant, anti-aging, wound healing, antioxidant, cytotoxic, analgesic, antibacterial, antimutagenic, insecticidal, and larvicidal. The most commonly described activities were attributed to the presence of terpenoids and phenolics. Further, some studies reported the preparation of nanoparticles and pharmaceutical formulations from the plant. This review highlights the potential of L. domesticum as herbal medicine. It provides an overview about the reported data on L. domesticum from 1931 to November 2021, including nutritional value, traditional uses, phytoconstituents, and bioactivities, as well as nanoparticles and pharmaceutical formulations.

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“…The tetranortriterpenoid, kokosanolide D (206) (Figure 25) was reported from Lansium domesticum fruit peels [121]. Biphenyl ether 207 was isolated from the fruit peel of Elaeagnus rhamnoides.…”

Section: Miscellaneousmentioning

confidence: 99%

Fruit Peels: Food Waste as a Valuable Source of Bioactive Natural Products for Drug Discovery

Hussain

Mamadalieva

Hussain

et al. 2022

CIMB

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Fruits along with vegetables are crucial for a balanced diet. These not only have delicious flavors but are also reported to decrease the risk of contracting various chronic diseases. Fruit by-products are produced in huge quantity during industrial processing and constitute a serious issue because they may pose a harmful risk to the environment. The proposal of employing fruit by-products, particularly fruit peels, has gradually attained popularity because scientists found that in many instances peels displayed better biological and pharmacological applications than other sections of the fruit. The aim of this review is to highlight the importance of fruit peel extracts and natural products obtained in food industries along with their other potential biological applications.

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Kokosanolide D: A New Tetranortriterpenoid from Fruit Peels of Lansium domesticum Corr. cv Kokossan

Cited by 7 publications

References 17 publications

Bioactivities Screening and Elucidation of Terpenoid from the Stembark Extracts of Lansium domesticum Corr. cv. Kokosan (Meliaceae)

Bioactivities Screening and Elucidation of Terpenoid from the Stembark Extracts of Lansium domesticum Corr. cv. Kokosan (Meliaceae)

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

Fruit Peels: Food Waste as a Valuable Source of Bioactive Natural Products for Drug Discovery

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