Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin

Choi, Hyunjung; Kim, Kwangmi; Han, Jiyeon; Choi, Hyun Jung; Sun, Jing; Lee, Eun Kyung; Shin, Dong Wook; Lee, Tae Ryong; Lee, Ai-Young; Noh, Minsoo

doi:10.1016/j.jdermsci.2012.03.002

Cited by 40 publications

(35 citation statements)

References 27 publications

(69 reference statements)

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“…The mechanism of epidermal hyper-pigmentation occurs by the increased expression level of ET-1 and SCF, or the decreased expression of TNF-α and IL-6. In particular, SCF and ET-1 are germane to the hyper-pigmentary mechanism by UVB-induced melanin synthesis [26][27][28][29][30]. Presently, GAE inhibited SCF-stimulated pigmentation in human epidermal equivalents.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of melanogenesis by Gaillardia aristata flower extract

Kim¹

2016

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 99%

Inhibition of melanogenesis by Gaillardia aristata flower extract

Kim¹

2016

Journal of Dermatological Science

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“…These enzymes not only are useful for fermentation but also contribute to the enhancement of the functional nutrient content of fermented products (Koseki et al, 1998). Furthermore, it has also been confirmed that koji mold produce the secondary metabolite as functional compounds such as kojic acid and pyranonigrin-A (Miyake et al, 2008; Choi et al, 2012). …”

Section: Introductionmentioning

confidence: 90%

Ricekojireduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice

Yoshizaki

Kawasaki

Cheng

et al. 2014

PeerJ

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Rice koji is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red koji have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of rice koji powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice koji groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow koji group. Blood glucose levels were significantly lower in the white and red koji groups with HOMA-R and leptin levels being reduced in the white koji group. White and red koji increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed.

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“…Moreover, they found out that decrease in tyrosinase protein expression was due to decrease in mRNA levels of MITF, tyrosinase, and TRP-2. 22,38 Therefore, it is reasonable to conclude that IL-6 secreted in the CM-hCBSC played a pivotal role in the anti-melanogenesis action in this study.…”

Section: Discussionmentioning

confidence: 62%

Effect of cultured medium of human umbilical cord blood-derived mesenchymal stem cells on melanogenic enzyme activity in mouse B16 melanoma cells

Hwang

Son

Park

et al. 2014

Tissue Eng Regen Med

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The cultured medium of mesenchymal stem cell is a valuable resource for a variety of stem cell-derived cytokines and growth factors with a potential therapeutic effect on skin diseases. Here, we investigated the effect of the cultured medium of human umbilical cord blood-derived mesenchymal stem cell (CM-hCBSC) on melanogenesis in mouse B16 melanoma cells stimulated by α-melanocyte stimulating hormone (α-MSH). Our results show that CM-hCBSC inhibits melanin synthesis due to the decrease in cellular tyrosinase activity in B16 melanoma cells without cytotoxicity. The activity of melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 were evaluated by western blot and semi-quantitative RT-PCR. The CM-hCBSC down-regulated the protein and mRNA expression levels of tyrosinase and TRP-1 in a dose-dependent manner. In addition, TRP-2 protein and mRNA expression levels were found to be down-regulated to a lesser extent. We also measured the level of cytokines in CM-hCBSC using the Luminex total system. It was found that the top enriched cytokine in the CMhCBSC was interukine-6 (IL-6), known as a potent regulator of melanin synthesis together with IL-1α and tumor necrosis factor α (TNF-α). These results indicate that secretary factors including IL-6 in the CM-hCBSC may inhibit melanin synthesis by down-regulating the expression of tyrosinase and TRP1. This study suggests that CMhCBSC has a therapeutic effect as an anti-melanogenic agent and may be effective against hyperpigmentation disorders.

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Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin

Cited by 40 publications

References 27 publications

Inhibition of melanogenesis by Gaillardia aristata flower extract

Inhibition of melanogenesis by Gaillardia aristata flower extract

Ricekojireduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice

Effect of cultured medium of human umbilical cord blood-derived mesenchymal stem cells on melanogenic enzyme activity in mouse B16 melanoma cells

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