Inhibition of melanogenesis by Gaillardia aristata flower extract

Kim, Minkyung

doi:10.1016/j.jdermsci.2016.08.529

Cited by 4 publications

(5 citation statements)

References 25 publications

(31 reference statements)

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“…Some other compounds such as anemonin and aloesin, butin of Spatholobus suberectus , plant herb and essential oil (EO) extracts significantly decreased the TYR, TRP1, and TRP2 mRNA expression in human epidermal melanocytes (HeMn) and melan‐a cells . Similar findings have been demonstrated for 7‐(hydroxy‐methoxyphenyl)‐1‐phenylhept‐4‐en‐3‐one (C 21 H 22 O 6 ), kaempferide (C 16 H 12 O 6 ), galangin (C 15 H 10 O 5 ), KA derivatives, flower extract of blanketflower ( G aristata ) as well as isofraxidin 7‐O‐(6′‐O‐p‐Coumaroyl)‐β‐glucopyranoside of Artemisia capillaries Thunberg where they remarkably reduced TYR activity as well as MITF, TRP1, and TRP2 protein expression level in various B16F10 cells and normal HeMn …”

Section: Depigmenting Compounds and Their Modulation On Melanogenesissupporting

confidence: 68%

“…Analysis of TYR activity has also been reported via TYR zymography whereby intracellular TYR in gels (ie, SDS‐PAGE) reacts with l ‐DOPA solution, and the intensity of the bands formed was visualized by a software (ie, ImageQuantTM LAS 4000 mini, Gel‐Print System) . Tyrosinase luciferase reporter assay has been also demonstrated using Renilla luciferase expression vector for the determination of intracellular TYR activity . On the other hand, TYR‐immunohistochemical fluorescence assay utilizes specific primary antibody with combination of a FITC‐secondary antibody, which can be subsequently visualized using a fluorescence microscope .…”

Section: Protocol and Assaysmentioning

confidence: 99%

“…50,74,103 Tyrosinase luciferase reporter assay has been also demonstrated using Renilla luciferase expression vector for the determination of intracellular TYR activity. 60 On the other hand, TYRimmunohistochemical fluorescence assay utilizes specific primary antibody with combination of a FITC-secondary antibody, which can be subsequently visualized using a fluorescence microscope. 103 As an internal control, the cell nuclei were stained with DAPI solution.…”

Section: Assaysmentioning

confidence: 99%

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Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Lajis

Ariff

2019

J of Cosmetic Dermatology

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Summary Human skin pigmentation is a result of constitutive and facultative pigmentation. Facultative pigmentation is frequently stimulated by UV radiation, pharmacologic drugs, and hormones whereby leads to the development of abnormal skin hyperpigmentation. To date, many state‐of‐art depigmenting compounds have been studied using in vitro model to treat hyperpigmentation problems for cosmetic dermatological applications; little attention has been made to compare the effectiveness of these depigmenting compounds and their mode of actions. In this present article, new and recent depigmenting compounds, their melanogenic pathway targets, and modes of action are reviewed. This article compares the effectiveness of these new depigmenting compounds to modulate several melanogenesis‐regulatory enzymes and proteins such as tyrosinase (TYR), TYR‐related protein‐1 (TRP1), TYR‐related protein‐2 (TRP2), microphthalmia‐associated transcription factor (MITF), extracellular signal—regulated kinase (ERK) and N‐terminal kinases (JNK) and mitogen‐activated protein kinase p38 (p38 MAPK). Other evidences from in vitro assays such as inhibition on melanosomal transfer, proteasomes, nitric oxide, and inflammation‐induced melanogenesis are also highlighted. This article also reviews analytical techniques in different assays performed using in vitro model as well as their advantages and limitations. This article also provides an insight on recent finding and re‐examination of some protocols as well as their effectiveness and reliability in the evaluation of depigmenting compounds. Evidence and support from related patents are also incorporated in this present article to give an overview on current patented technology, latest trends, and intellectual values of some depigmenting compounds and protocols, which are rarely highlighted in the literatures.

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Section: Depigmenting Compounds and Their Modulation On Melanogenesissupporting

confidence: 68%

Section: Protocol and Assaysmentioning

confidence: 99%

Section: Assaysmentioning

confidence: 99%

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Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Lajis

Ariff

2019

J of Cosmetic Dermatology

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“…Hence, antioxidants regulate the important role in hyperpigmentation or melanogenesis. 8 In this study, we have screened those extracts for antioxidants and antimelanogenesis as seen in Table 1 in order to evaluate its potency as cosmetic ingredient. Based on Table 1 , Figure 1, and thin layer chromatography (TLC), the leaf extract of M. pruinosa was chosen for further fractionation to isolate the active compound.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Antimelanogenesis Activities of Glyasperin A From Macaranga pruinosa Leaves

Arung

Sinamabela

Rosamah

et al. 2019

Natural Product Communications

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In our effort to find materials for drugs and cosmetics from tropical natural resources, we screened 21 methanol extracts from 7 Macaranga trees species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa, and Macaranga triloba) for antioxidant and antimelanogenesis. The antioxidant and melanogenesis (tyrosinase enzyme assay and melanin inhibitor in B16 melanoma) assays were used to determine the activities. The fractionation and the isolation of active compound were done by various chomatographic methods and the structure was determined by spectroscopic analysis data. We isolated a prenylated flavonoid, named Glyasperin A, from M. pruinosa leaf. This compound showed a potency as antioxidant and inhibited melanin in B16 melanoma but not tyrosinase activity. These results showed that the methanol leaf extracts of M. pruinosa could be developed for cosmetic applications especially as a skin whitening agent.

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“…Therefore, many compounds have been reported as free radical scavengers, antioxidants, and melanin inhibitors, such as vitamin C, arbutin, kojic acid, ellagic acid, tranexamic acid, potassium methoxysalicylate, and 5,5-dipropyl-biphenyl-2,2-diol, which are important to protect human skin from the damaging effects of UV radiation, such as hyperpigmentation. 2,3 Stingless bees are a group of insects belonging to 5 genera (Dectylurina, Melipona, Meliponula, Lestrimelitta, and Trigona), which play an important role in plant pollination. 4 These genera also produce propolis; a mixture of beeswax, plant resins, and pollens which is used to seal their beehives.…”

mentioning

confidence: 99%

Prenylated Flavonoids as Antioxidant and Melanin Inhibitors From Stingless Bee (Wallacetrigona incisa) Propolis

Arung

Syafrizal

Pasedan

et al. 2020

Natural Product Communications

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Propolis from 4 stingless bees ( Homotrigona apicalis, Wallacetrigona incisa, Tetragonula fuscobalteata, and Tetragonula fuscibasis) was investigated in the search for medicinal and cosmetic materials from tropical rainforest resources. Methanol extracts of the propolis were screened using antioxidant and antimelanogenesis assays (tyrosinase enzyme activity and melanin inhibitor in B16 melanoma). The extract of H. apicalis showed the strongest antioxidant activity, both in the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assays, with half-maximal inhibitory concentration values of 0.72 ± 0.01 (mg/mL) and 0.26 ± 0.00 (mg/mL), respectively. The H. apicalis extract also displayed the strongest inhibition of tyrosinase (53% at 100 µg/mL). In the B16 melanoma cell assay, the W. incisa extract showed the strongest inhibition of melanin (21%) and was less cytotoxic. The W. incisa extract was fractioned to isolate the compounds with biological activities. Two prenylated flavonoids were obtained, named broussoflavonol F and glyasperin A. Both showed potent antioxidant activities, as well as inhibiting melanin in B16 melanoma, but not tyrosinase activity. These results indicated the potential of methanol extract of W. incisa to be developed for cosmetic material, but further experiments are needed to verify the function.

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Inhibition of melanogenesis by Gaillardia aristata flower extract

Cited by 4 publications

References 25 publications

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Antioxidant and Antimelanogenesis Activities of Glyasperin A From Macaranga pruinosa Leaves

Prenylated Flavonoids as Antioxidant and Melanin Inhibitors From Stingless Bee (Wallacetrigona incisa) Propolis

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