Knowledge, Attitudes, and Practice Regarding Research Ethics Committees Among Health Care Faculty at Two Public Universities in Jordan

Ayoub, Nehad M.; Qandil, Abeer M.; McCutchan, J. Allen

doi:10.1177/1556264619851351

Cited by 13 publications

(8 citation statements)

References 40 publications

(60 reference statements)

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“…9,10 Informed consent, privacy, confidentiality, data storage and bio-specimen collection, and further analysis are some of ethical challenges of genetic studies in Jordan. [10][11][12][13] Despite numerous publications that address ethical issues related to informed consent in genetic studies, very little is known about consenting genetic studies in the Arab region. 8,14 In this study, we aimed to assess the content of different ICFs from genetic studies conducted in Jordan to determine the degree of compliance according to essential requirements proposed by ICHGCP.…”

Section: Introductionmentioning

confidence: 99%

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

Alkaraki¹,

Khabour²,

Alzoubi³

et al. 2020

JMDH

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Background: Informed consent is an obligatory requirement for research engaging human subjects. Informed consent form (ICF) should be provided for human subjects to confirm their willingness for voluntary participation in a study. Ethical and legal obligations necessitate the presence of informed consent essential items to be built into the ICF. Objective: To evaluate the content of ICFs obtained from different genetic studies accomplished in Jordan and their adherence to ethical guidelines proposed by the International Conference on Harmonization-Good Clinical Practice (ICHGCP). Methods and Measures: A total of 44 ICFs obtained from master theses and grant proposals at two major universities in Jordan were analyzed according to the good clinical practice criteria proposed by ICHGCP. ICFs were scored for the presence or absence of ICF main items/categories. Results: Results show inadequate information present in the examined ICFs. The highest information score was 17 out of 20, while the lowest score was one out of 20. The average score for all studied ICFs was 6.18±3.65. Among essential items/categories that were absent from the majority of studied ICFs were a statement about voluntary participation, confidentiality of data, compensation to study participants, risk/benefits of the study, and researchers' contact information. Conclusion: The ICFs were missing a number of required items. This could reflect inadequate knowledge about minimal informed consent requirements among Jordanian investigators highlighting the need for research ethical training in the country.

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Section: Introductionmentioning

confidence: 99%

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

Alkaraki¹,

Khabour²,

Alzoubi³

et al. 2020

JMDH

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“…to continue serving in the committees. Similarly, a recent Jordanian study exploring researchers' attitudes and perceptions toward REC members found that participants raised concern regarding members' level of training and knowledge regarding medical ethics (Ayoub et al, 2019). There is a need to recruit members who are qualified, certified, and with experience (Amdur & Bankert, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have been conducted to evaluate the RECs from researchers' perspectives, concluding, for example, that members spend too long reviewing proposals, delaying the research (El-Dessouky et al, 2011;Grady, 2015;Makhoul et al, 2014); and that members should possess certificates in research ethics (Rababa'h, 2020). They also believed that their research proposals during the review process may be subjected to potential conflicts of interest and bias (Ayoub et al, 2019), and in general, that researchers do not well understand the role of RECs (Tarboush et al, 2020). From the opposite perspective, members of RECs reported several challenges, including: limited experience of the members of ethics committees; limited ability to prolong membership of the members; limited…”

Section: Introductionmentioning

confidence: 99%

Perceptions of Challenges Affecting Research Ethics Committees’ Members at Medical and Health Science Colleges in Omani and Jordanian Universities

et al. 2021

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In recent years there has been an increase in research conducted in the Middle East, with a corresponding increase in the challenges faced by members of the Research Ethics Committees (RECs). This study compares the structures of Omani and Jordanian RECs and investigates the perceptions of the challenges affecting the work of the REC members in Oman and Jordan. A convenience sample of 34 Omani and 66 Jordanian participants from 21 universities was recruited in this cross-sectional study. Almost 70% disagreed that the members of RECs are unqualified, providing comments without justification; half believed that members have limited experience in research, and almost three-quarters that they have different opinions regarding some ethical issues. No significant differences were found between Omani and Jordanian REC members regarding their perception of the challenges, except for the perception that reviewing proposals is a time-consuming task (p = 0.048) and that multi-REC centres are less available (p = 0.026). The regression model showed that there were significantly more male members of Jordanian RECs, and that Jordanian members were less likely to receive formal training. In conclusion, the current structure of RECs and the challenges faced by members need to be re-evaluated by decision makers to improve the overall quality of research activities, and to ensure that current REC members’ practices adhere to international standards.

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“…More importantly, these findings suggest CR participation as an effective strategy to promote positive attitudes towards CR. In addition, although not assessed in the current study, several studies from Jordan highlighted ethical challenges in CR which include the IRB review process, the informed consent process, and lack of ethical training for researchers [72][73][74][75][76][77]. As a result, implementing research ethics guidelines as well as…”

Section: Plos Onementioning

confidence: 98%

Motivators and barriers towards clinical research participation: A population-based survey from an Arab MENA country

Al-Shami

Ahmed²,

Alzoubi³

2022

PLoS ONE

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Jordan was the first Arab country to enact clinical research regulations. The country has a well-flourished pharmaceutical industry that leans heavily on clinical research (CR) for drug development and post-marketing surveillance. In this cross-sectional study, we sought to assess the public’s awareness and attitude towards CR as well as their perceived motivators and barriers to CR participation. A population-based, self-administered questionnaire was distributed to the general public in Jordan. Among the 1061 participants in this survey, 74% reported being aware of CR. The majority (70%) agreed to the role of CR in health promotion. Online information and healthcare staff were the two main sources of CR information for the participants. About 25% of the participants received prior invitations to participate in CR with 21% agreeing to participate. However, most participants of the current study (63%) were willing to participate in future CR. Contributing to science, benefiting others, and promoting one’s own health were the top motivating factors for participating in CR; while time constraints, fear of research procedure, and lack of interest were the most cited reasons for rejecting participation. Filling out questionnaire surveys, donating blood samples, and participating in physical examinations were the main CR contributions of the participants. Nearly 31% of the participants believed that CR is conducted in a responsible and ethical manner, while 57% did not have an opinion regarding the same matter. In addition, 49% and 44% were neutral with regards to the degree of harm and confidentiality posed by CR. While only 27% disagreed that CR exposes participants to some form of harm, 48% either strongly agreed (15%) or agreed (33%) that it maintains high level of confidentiality for participants. The current study provides insight into the public’s perception of CR in Jordan as well as its motivating factors and perceived barriers towards participating in CR. We envisage to utilize this insight as an aid in the design of vigilant future awareness campaigns and recruitment strategies.

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Knowledge, Attitudes, and Practice Regarding Research Ethics Committees Among Health Care Faculty at Two Public Universities in Jordan

Cited by 13 publications

References 40 publications

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

<p>Informed Consent Form Challenges for Genetic Research in Jordan</p>

Perceptions of Challenges Affecting Research Ethics Committees’ Members at Medical and Health Science Colleges in Omani and Jordanian Universities

Motivators and barriers towards clinical research participation: A population-based survey from an Arab MENA country

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