Knollenblätterpilzvergiftung

Ganzert, Martin; Felgenhauer, Norbert; Schuster, T; Eyer, Florian; Gourdin, C; Zilker, Thomas

doi:10.1055/s-0028-1091268

Cited by 51 publications

(9 citation statements)

References 12 publications

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“…Silymarin contains silybin (also named as silibinin) as key ingredient, which is a flavonolignans mixture; however, small quantities of chemically unknown constituents are also present in silymarin [ 114 ]. Although the clinical effectiveness of silymarin has been reported in several publications, no study evidently describes the clinical efficacy of thistle milk products [ 115 , 116 ]. This scarcity could be attributed to the ambiguous terminologies used for thistle milk products [ 114 ].…”

Section: Selected Botanical Supplements and Their Interactionsmentioning

confidence: 99%

“…This scarcity could be attributed to the ambiguous terminologies used for thistle milk products [ 114 ]. The intoxications due to ingestion of Amanita phalloides , a lethal fungus, has been effectively treated by silymarin [ 114 , 116 , 117 ], while a formulation with defined quantities of its constituents is being marketed [ 117 ]. The literature study showed no evidence about the accurate mode of silymarin action against Amanita phalloides , but the antioxidant potential, among others, is an important property of this botanical supplement [ 112 , 117 , 118 ].…”

Section: Selected Botanical Supplements and Their Interactionsmentioning

confidence: 99%

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Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

et al. 2017

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In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.

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Section: Selected Botanical Supplements and Their Interactionsmentioning

confidence: 99%

Section: Selected Botanical Supplements and Their Interactionsmentioning

confidence: 99%

Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

et al. 2017

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“…Severe mushroom poisoning caused by amanitin remains an unresolved problem in clinical toxicology because no specific and fully efficient antidote is ready available (1,16,25). The recommended therapeutic regimen in A. phalloides poisoning includes gastrointestinal decontamination procedures, rehydration, correction of metabolic acidosis and electrolyte abnormalities, specific therapies (silibinin, Nacetylcystein, Penicillin G, MARS) and liver transplantation (3,4,13,16,26,27,28). In Bulgaria, Silibinin, (3,22,31,32), or 30% in adults and 50% in children (4,8).…”

Section: Resultsmentioning

confidence: 99%

Poisoning with Amanita phalloides (Vaill. ex Fr.) Link - 25-years retrospective analysis in Varna region, Bulgaria

Ivanov¹,

Marinov²,

Zlateva³

et al. 2018

Scripta Scientifica Pharmaceutica

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Fungal intoxications are important in the ethology of acute exogenous intoxications and A. phalloides mushrooms intoxications are the most important for clinical toxicology. Poisonings with A. phalloides mushrooms are infrequent, but they have high lethality due to their high toxicity. A retrospective analysis of poisonings with A. phalloides mushrooms in Varna region for a period of 25 years (1991-2015) was conducted and 147 patients have been registered. The frequency relative to all hospitalised patients with acute poisoning is 0.8%. Such intoxications are more common in males and the ratio of men to women is 1.62:1. The largest number of intoxications was registered in the age group of 45 to 60 years-62 (42.2%). All intoxications occured following oral ingestion of A. phalloides mushrooms by mistake instead of edible mushrooms such as field mushroom-Agaricus campestris L. A lethal outcome was registered in 25 patients (17%). A. phalloides mushrooms account for 11.4% of the lethality in acute poisonings.

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“…Mantar zehirlenmelerinde henüz kür sağlayan bir tedavi bulunmamakla birlikte, penisilinlerin tek başına veya silibinin ile kombinasyonunda mantar zehirlenmesinde kullanımı mevcuttur [9] . Mekanizması tam olarak anlaşılamasa da protein sentez inhibisyonu ve serbest oksijen radikallerinin inhibisyonu üzerinden bu etkiyi yaptığı düşünülmektedir [10] .…”

Section: Mantar Zehirlenmelerinde Kullanımıunclassified

Non Antimicrobial Effects of Antibacterial Agents

Demiraslan¹,

Uysal²

2018

mjima

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Aside from their antibacterial activity, antimicrobial agents have also some beneficial effects due to their chemical structures. These effects include anti-inflammatory, immunomodulatory, anti-cancer, anti-angiogenic, neuroprotective, cardioprotective, augmented gastrointestinal motility, and binding toxins. This paper does not comprise non-antimicrobial effects of all antibiotics due to the fact that the issue is very extended. We reviewed use of penicillins in mushroom poisoning and their promising inhibitor effect on proliferation of cervical carcinoma and leukemia cells. We summarized neuroprotective effect of ceftriaxone and its inhibitory potential on proliferation of lung cancer cells. Tetracyclines are agents that have been focused on and investigated for a long time, and demeclocycline that belongs to this group is used for inappropriate antidiuretic hormone secretion. Moreover, low-dose doxycycline that is also a tetracycline, has been approved for the treatment of periodontitis, and inhibition of matrix metalloproteinase enzyme is the responsible mechanism for its anti-inflammatory action. Matrix metalloproteinase inhibition also provides a decrease in tumor angiogenesis and metastasis. Minocycline, another tetracycline, reduces the synthesis of beta-amyloid which plays a key role in Alzheimer's disease and other neurodegenerative diseases, and it also inhibits glial inducible nitric oxide (NO) synthase and NOmediated neurotoxicity. Erythromycin that is a macrolide antibiotic is used as a gastrointestinal motility augmenter; azithromycin gives an early improvement in patients with cystic fibrosis due to its anti-inflammatory effect. It has been shown that clarithromycin decreases the metastatic AbstractAntimikrobiyal ajanlar kimyasal yapılarından dolayı bakterilere karşı aktiviteleri dışında bazı yararlı etkilere de sahiptirler. Bunlar arasında antienflamatuvar, immünomodülatör, anti-kanser, anti-anjiyogenik, nöroprotektif, kardiyoprotektif, gastrointestinal hareket artırıcı ve toksin bağlayıcı etkiler sayılabilir. Bu yazıda, konu çok geniş olduğundan dolayı sınırlı sayıda antibiyotiğin antimikrobiyal dışı etkileri ele alınmıştır. Penisilinlerin serviks ve lösemik kanser hücrelerinin çoğalmasını durdurma konusunda ümit vaat edici etkisi ve mantar zehirlenmesi tedavisinde kullanımı; seftriaksonun akciğer kanseri hücreleri üzerindeki çoğalmayı önleyici potansiyeli ve nöroprotektif etkisi derlenmiştir. Tetrasiklinler uzun süredir üzerinde durulan ve araştırılan ajanlardır ve bu gruptaki demeklosiklin, uygunsuz antidiüretik hormon salınımında kullanılmaktadır. Ayrıca tetrasiklinlerden doksisiklin düşük dozda periodontit tedavisi için onay almıştır ve anti-enflamatuvar etkiden sorumlu mekanizma matriks metalloproteinaz (MMP) enzimi inhibisyonudur. Ayrıca MMP inhibisyonu metastazda ve tümör anjiyogenezinde azaltma da sağlayabilmektedir. Diğer bir tetrasiklin olan minosiklin ise Alzheimer ve diğer nörodejeneratif hastalıklarda kilit rolü olan beta-amilod sentezini azaltmakta ve ayrıca gliyal indüklenebilir ...

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Knollenblätterpilzvergiftung

Cited by 51 publications

References 12 publications

Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

Poisoning with Amanita phalloides (Vaill. ex Fr.) Link - 25-years retrospective analysis in Varna region, Bulgaria

Non Antimicrobial Effects of Antibacterial Agents

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