Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha

Xiao, Xiao; Shen, Yingying; Yin, Liyang; He, Jun; Ni, Xiaoyu; Luo, Gang; Chen, Xiguang; Zhu, Wenbo; Zhong, Jing; Liu, Jianghua; Peng, Xiuda; Zu, Xuyu

doi:10.1016/j.lfs.2019.117042

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…41 Some evidence has indicated that the expression of FBI-1 in breast cancer tissues also exhibits significantly higher than that in normal tissues and benign breast disease tissues, which is consistently correlated to the poor prognosis, 20,21,22 and antagonizing FBI-1 could suppress proliferation, arrest cell cycle and promote apoptosis of breast cancer cells. 22,42,43 Consequently, our recent study also confirmed that abnormally high expression of FBI-1 was noted in breast cancer tissues and breast cancer cell lines MCF-7 as well as MDA-MB-231. Besides, FBI-1 overexpression promoted migration, invasion and metastasis, while FBI-1 silencing generated the opposite effects.…”

Section: Discussionsupporting

confidence: 73%

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen¹,

Xiao²,

Yang³

et al. 2021

DDDT

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Section: Discussionsupporting

confidence: 73%

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen¹,

Xiao²,

Yang³

et al. 2021

DDDT

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“…Furthermore, some study has found that the expression of KLF1 increased the expression of fetal globin repressor Zinc Finger and BTB Domain Containing 7A (ZBTB7A) in erythroid cells [ 12 ]. ZBTB7A is a member of the POK protein family and plays a critical role in the process of cell differentiation [ 13 , 14 ]. Moreover, ZBTB7A can regulate the activity of Wnt signaling pathway in non-small cell lung cancer cells and thereby accelerating the cancer progression [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Krüppel-like factor 1 (KLF1) promoted the proliferation, migration and invasion of human lens epithelial cells by enhancing the expression of Zinc Finger and BTB Domain Containing 7A (ZBTB7A) and activating Wnt/β-catenin pathway

Shi

Yang

2021

Bioengineered

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“…After 48 h, the cells were treated with 20 μM MG132 for 6 h and then collected to purify the RhoC protein. The polyubiquitinated RhoC protein from the cell lysate was separated on SDS‐polyacrylamide gels, transferred to PVDF membranes and blotted with anti‐ubiquitin antibody (Cell Signaling Technology) 19 …”

Section: Methodsmentioning

confidence: 99%

“…The polyubiquitinated RhoC protein from the cell lysate was separated on SDS-polyacrylamide gels, transferred to PVDF membranes and blotted with anti-ubiquitin antibody (Cell Signaling Technology). 19…”

Section: Ubiquitination Assaymentioning

confidence: 99%

Quercetin‐induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis

Huang,

Lai,

Mao

et al. 2024

Cancer Medicine

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BackgroundTumor metastasis and recurrence are major causes of mortality in patients with hepatocellular carcinoma (HCC) that is still lack of effective therapeutic targets and drugs. Previous reports implied that ras homolog family member C (RhoC) plays a toxic role on metastasis and proliferation of cancer.MethodsIn this research, the correlation between RhoC and metastasis ability was confirmed by in vitro experiments and TCGA database. We explored whether quercetin could inhibit cell migration or invasion by transwell assay. Real‐time PCR, overexpression and ubiquitination assay, etc. were applied in mechanism study. Primary HCC cells and animal models including patient‐derived xenografts (PDXs) were employed to evaluate the anti‐metastasis effects of quercetin.ResultsClinical relevance and in vitro experiments further confirmed the level of RhoC was positively correlated with invasion and metastasis ability of HCC. Then we uncovered that quercetin could attenuate invasion and metastasis of HCC by downregulating RhoC's level in vitro, in vivo and PDXs. Furthermore, mechanistic investigations displayed quercetin hindered the E3 ligase expression of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) leading to enhancement of RhoC's ubiquitination and proteasomal degradation.ConclusionsOur research has revealed the novel mechanisms quercetin regulates degradation of RhoC level by targeting SMURF2 and identified quercetin may be a potential compound for HCC therapy.

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Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha

Cited by 13 publications

References 29 publications

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Krüppel-like factor 1 (KLF1) promoted the proliferation, migration and invasion of human lens epithelial cells by enhancing the expression of Zinc Finger and BTB Domain Containing 7A (ZBTB7A) and activating Wnt/β-catenin pathway

Quercetin‐induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis

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