Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen, Maojian; Xiao, Chanchan; Yang, Weiping; Qin, Qinghong; Tan, Qian; Lian, Bin; Liang, Zheng; Wei, Changyuan

doi:10.2147/dddt.s269901

Cited by 62 publications

(37 citation statements)

References 67 publications

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“…Furthermore, NF-κB, the target gene of FBI-1, was also inactivated by capsaicin treatment. These results indicate that the proapoptotic effect of capsaicin is related to the FBI-1-mediated NF-κB pathway (Chen et al, 2021).…”

Section: Nf-κb-mediated Apoptosismentioning

confidence: 71%

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

et al. 2022

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Breast cancer is one of the top-ranked malignant carcinomas associated with morbidity and mortality in women worldwide. Chemotherapy is one of the main approaches to breast cancer treatment. Breast cancer initially responds to traditional first- and second-line drugs (aromatase inhibitor, tamoxifen, and carboplatin), but eventually acquires resistance, and certain patients relapse within 5 years. Chemotherapeutic drugs also have obvious toxic effects. In recent years, natural products have been widely used in breast cancer research because of their low side effects, low toxicity, and good efficacy based on their multitarget therapy. Apoptosis, a programmed cell death, occurs as a normal and controlled process that promotes cell growth and death. Inducing apoptosis is an important strategy to control excessive breast cancer cell proliferation. Accumulating evidence has revealed that natural products become increasingly important in breast cancer treatment by suppressing cell apoptosis. In this study, we reviewed current studies on natural product–induced breast cancer cell apoptosis and summarized the proapoptosis mechanisms including mitochondrial, FasL/Fas, PI3K/AKT, reactive oxygen species, and mitogen-activated protein kinase–mediated pathway. We hope that our review can provide direction in the search for candidate drugs derived from natural products to treat breast cancer by promoting cell apoptosis.

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Section: Nf-κb-mediated Apoptosismentioning

confidence: 71%

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

et al. 2022

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“…Therefore, this study not only has scientific research value but also has great clinical value. The HCC cells may be resistant to molecular targeted drugs through a variety of mechanisms: (1) compensation between different signaling pathways (77-79);…”

Section: Discussionmentioning

confidence: 99%

“…As an important transcription inhibitor (the transcription suppressor), the positive regulator of human malignancies/pro-oncogene (positive regulator/pro-oncogene) FBI-1 (factor that binds to inducer of short transcripts-1) is produced by Zbtb7A (zinc finger and BTB domain protein family 7A) and plays important roles in cancerous cells' proliferation or metastasis (1,2). The FBI-1 was also named as other names: (1) osteoclast-derived zinc finger (OCZF), (2) leukemia-related factor (LRF) (3)(4)(5), and (3) Pokemon (POK erythroid myeloid oncogenic factor) (6,7).…”

Section: Introductionmentioning

confidence: 99%

Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α

Liu¹,

Yang²,

Huang³

et al. 2021

Front. Oncol.

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The transcription suppressor factor FBI-1 (the factor that binds to inducer of short transcripts-1) is an important regulator of hepatocellular carcinoma (HCC). In this work, the results showed that FBI-1 promoted the Warburg effect and enhances the resistance of hepatocellular carcinoma cells to molecular targeted agents. Knockdown of FBI-1 via its small-interfering RNA (siRNA) inhibited the ATP level, lactate productions, glucose uptake or lactate dehydrogenase (LDH) activation of HCC cells. Transfection of siFBI-1 also decreased the expression of the Warburg-effect-related factors: hypoxia-inducible factor-1 alpha (HIF-1α), lactate dehydrogenase A (LDHA), or GLUT1, and the epithelial–mesenchymal transition-related factors, Vimentin or N-cadherin. The positive correlation between the expression of FBI-1 with HIF-1α, LDHA, or GLUT1 was confirmed in HCC tissues. Mechanistically, the miR-30c repressed the expression of HIF-1α by binding to the 3′-untranslated region (3′-UTR) of HIF-1α in a sequence-specific manner, and FBI-1 enhanced the expression of HIF-1α and HIF-1α pathway’s activation by repressing the expression of miR. By modulating the miR-30c/HIF-1α, FBI-1 promoted the Warburg effect or the epithelial–mesenchymal transition of HCC cells and promoted the resistance of HCC cells to molecular targeted agents.

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“…The authors proposed that capsaicin treatment may help alleviate the growth of cancer cells in patients. Chen et al also reported that capsaicin (10 mg/kg, every third day) can decrease the growth of breast cancer in a Xenograft nude mouse model in vivo by downregulating the FBI-1-NF-κB pathway [ 57 ]. However, while noting the anti-tumor potential of capsaicin, one should not disregard an earlier report by Toth and Gannett [ 58 ] demonstrating that lifelong administration of capsaicin in Swiss mice resulted in an increased incidence of benign tumors of the cecum.…”

Section: The Beneficial Roles Of Capsaicin and Trpv1mentioning

confidence: 99%

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation

Munjuluri

Wilkerson

Sooch

et al. 2021

Cells

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Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel and is a common component found in the fruits of the genus Capsicum plants, which have been known to humanity and consumed in food for approximately 7000–9000 years. The fruits of Capsicum plants, such as chili pepper, have been long recognized for their high nutritional value. Additionally, capsaicin itself has been proposed to exhibit vasodilatory, antimicrobial, anti-cancer, and antinociceptive properties. However, a growing body of evidence reveals a vasoconstrictory potential of capsaicin acting via the vascular TRPV1 channel and suggests that unnecessary high consumption of capsaicin may cause severe consequences, including vasospasm and myocardial infarction in people with underlying inflammatory conditions. This review focuses on vascular TRPV1 channels that are endogenously expressed in both vascular smooth muscle and endothelial cells and emphasizes the role of inflammation in sensitizing the TRPV1 channel to capsaicin activation. Tilting the balance between the beneficial vasodilatory action of capsaicin and its unwanted vasoconstrictive effects may precipitate adverse outcomes such as vasospasm and myocardial infarction, especially in the presence of proinflammatory mediators.

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Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Cited by 62 publications

References 67 publications

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review

Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation

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