Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma

Zang, Wenqiao; Wang, Tao; Wang, Yuanyuan; Chen, Xiaonan; Du, Yuwen; Sun, Qianqian; Li, Min; Dong, Ziming; Zhao, Guoqiang

doi:10.18632/oncotarget.6963

Cited by 79 publications

(91 citation statements)

References 39 publications

(33 reference statements)

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“…TP73-AS1 was associated with cell proliferation and tumor progression. TP73-AS1 knockdown suppressed cancer cell proliferation and induced apoptosis in esophageal squamous cell carcinoma [22] and knockdown of TP73-AS1 also induced apoptosis in glioblastoma cells [27]. In ccRCC, we also identified that TP73-AS1 induced cell proliferation, migration and inhibits cell apoptosis.…”

Section: Discussionmentioning

confidence: 68%

“…Thereafter, it was reported that TP73-AS1 was generally upregulated in esophageal cancer tissues and was strongly associated with malignant level in clinical samples. Besides, TP73-AS1 knockdown could enhance the chemosensitivity of esophageal cancer cells to 5-FU and cisplatin [22]. These opposite changes indicated its heterogeneity in different cancer.…”

Section: Discussionmentioning

confidence: 95%

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LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway

Liu¹,

Zhao²,

Zhou³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Emerging evidence suggests that long non-coding RNAs (lncRNAs) play a vital regulatory role in the pathogenesis and progression of renal cell carcinoma (RCC). We aim to determine lncRNA profiles in clear cell RCC (ccRCC) and investigate key lncRNAs involved in ccRCC tumorigenesis and progression. Methods: RNA sequencing technique and qPCR were used to determine the candidate lncRNAs in ccRCC tissues. The correlations between lncRNA P73 antisense RNA 1T (TP73-AS1) levels and survival outcomes were analyzed to elucidate its clinical significance. The underlying mechanisms of TP73-AS1 in ccRCC were analyzed through in vitro functional assays. Results: We found TP73-AS1 was upregulated in 40 ccRCC tissues compared with adjacent normal renal tissues and increased TP73-AS1 was correlated to aggressive clinicopathologic features and unfavorable prognosis. Knockdown of TP73-AS1 suppressed cell proliferation, invasion and induced cell apoptosis. We also identified KISS-1 metastasis-suppressor (KISS1) was significantly upregulated in TP73-AS1 knockdown cells. Further, we revealed that TP73-AS1 suppressed KISS1 expression through the interaction with Enhancer of zeste homolog 2 (EZH2) and the specific binding to KISS1 gene promoter region. Knockdown of KISS1 partly reversed TP73-AS1 knockdown-induced inhibition of cell proliferation and promotion of apoptosis. We further determined that TP73-AS1 knockdown activated PI3K/Akt/mTOR signaling pathway, while overexpression of TP73-AS1 induced inhibition of PI3K/Akt/mTOR pathway and these effects could be partly abolished by overexpression of KISS1. Conclusion: In conclusion, we identified that TP73-AS1 as an oncogenic lncRNA in the development of ccRCC and a potential target for human renal carcinoma treatment.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 95%

LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway

Liu¹,

Zhao²,

Zhou³

et al. 2018

Cell Physiol Biochem

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“…They are associated with a variety of biological processes, including cell proliferation, cell cycle, differentiation and apoptosis, primarily by the regulation of gene expression through chromatin remodeling, RNA maturation, transport and protein synthesis (8). Advances in the depth and quality of transcript me sequencing have revealed a range of lncRNAs classes dysregulated in various human diseases, particularly cancer (9)(10)(11). H19 is a member of a highly-conserved cluster of imprinted genes, and was the first lncRNA to be associated with cancer (12).…”

Section: Introductionmentioning

confidence: 99%

Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells

et al. 2017

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Abstract. Long non-coding RNAs (lncRNAs) are emerging as a fundamental class of biological effect or molecules that perform pivotal functions in the regulation of the genome. With advances in bioinformatics and genomics, extensive identification and characterization of lncRNAs is now possible. They regulate cellular growth, differentiation and apoptosis. Dysregulation of lncRNAs has been associated with numerous types of human cancer. In the present study, the expression profile of differentially expressed genes (DEGs) and lncRNAs in gastric cancer (GC) samples and normal tissue samples was evaluated with bioinformatics. The biological functions of the predicted lncRNA TCONS_00068220 were focused on; the DEGs co-expressed with TCONS_00068220 were enriched in cancer-associated pathways. TCONS_00068220 was demonstrated to be upregulated in GC tissues and cell lines compared with normal controls. In addition, an increased rate of apoptosis was observed in NCI-N87 cells following transfection with small interfering RNA against TCONS_00068220. These data suggest that TCONS_00068220 may be associated with the pathogenesis of GC, and it may serve as a potential therapeutic target.

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“…Hence, MIAT could be directed at a novel and hopeful biomarker and therapeutic target for ERpositive BC.3.1.7 | LncRNA TP73-AS1/miR-200a/mRNAs TFAM and ZEB1There are some reports that P73 antisense RNA 1T (TP73-AS1) lncRNA is involved in several types of tumors through regulating the ABDOLLAHZADEH ET AL. | 10087 apoptosis by influencing the expression of P53-related antiapoptotic genes(Hui-rui & Jun-dong, 2016;Zang et al, 2016). A new study byYao et al (2017) revealed the oncogene activity of lncRNA TP73-AS1 in BC thorough functioning as a sponging ceRNA on miR-200a for activating the TFAM mRNA.…”

mentioning

confidence: 99%

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

Abdollahzadeh

Daraei

Mansoori

et al. 2018

Journal Cellular Physiology

229

185

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Breast cancer (BC) is the most frequently occurring malignancy in women worldwide. Despite the substantial advancement in understanding the molecular mechanisms and management of BC, it remains the leading cause of cancer death in women. One of the main reasons for this obstacle is that we have not been able to find the Achilles heel for the BC as a highly heterogeneous disease. Accumulating evidence has revealed that noncoding RNAs (ncRNAs), play key roles in the development of BC; however, the involving of complex regulatory interactions between the different varieties of ncRNAs in the development of this cancer has been poorly understood. In the recent years, the newly discovered mechanism in the RNA world is “competing endogenous RNA (ceRNA)” which proposes regulatory dialogues between different RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs). In the latest BC research, various studies have revealed that dysregulation of several ceRNA networks (ceRNETs) between these ncRNAs has fundamental roles in establishing the hallmarks of BC development. And it is thought that such a discovery could open a new window for a better understanding of the hidden aspects of breast tumors. Besides, it probably can provide new biomarkers and potential efficient therapeutic targets for BC. This review will discuss the existing body of knowledge regarding the key functions of ceRNETs and then highlights the emerging roles of some recently discovered ceRNETs in several hallmarks of BC. Moreover, we propose for the first time the “ceRnome” as a new term in the present article for RNA research.

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Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma

Cited by 79 publications

References 39 publications

LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway

LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway

Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

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