“…Activation of the P38/COX‐2 signaling (J.‐H. Baek et al, ) induces ROS overproduction (Z. Xu et al, ) that is further contributed to promotion of apoptosis in cancers like osteosarcoma. For glioma, there are two opposite views for the roles of COX‐2 overexpression with either enhancement of cancer promotion through interaction between COX‐2 with NF‐κβ (X. Wang, Yu, et al, ; J. Zhao, Zhu, et al, ), WNT (Wu et al, ), and EGFR (J. Li, Zhou, et al, ) for respective induction of inflammation, CSC activity and survival in cancer cells, or suppression of tumor progression through possible interaction between COX‐2 with the endocannabinoid system that further elicits proapoptotic actions in this system (Hinz, Ramer, Eichele, Weinzierl, & Brune, ).…”