Contribution of regulatory T cells to cancer: A review

Najafi, Masoud; Farhood, Bagher; Mortezaee, Keywan

doi:10.1002/jcp.27553

Cited by 157 publications

(117 citation statements)

References 100 publications

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“…GRP signalling alters the invasion of colon cancer through heterochromatin protein 1 Hsβ and can improve the prognosis of colon cancer patients [43]. Moreover, T cells regulatory (Tregs) and Macrophage M0 are related to poor clinical prognosis of many cancer patients [44,45]. While Dendritic cells are associated with cancer immunity and good prognosis [46].…”

Section: Discussionmentioning

confidence: 99%

Establishment of an immune-related gene pairs model to predict colon adenocarcinoma prognosis

Luo

Liu

Wang

et al. 2020

Preprint

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Background. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma(COAD) is the main pathological type of colon cancer. There is a lot of evidence describing the correlation between the prognosis of COAD and the immune system. The objective of the current study was the development of a robust prognostic immune-related gene pairs (IRGPs) model for estimating overall survival of COAD. Methods. The gene expression profiles and clinical information of patients with colon adenocarcinoma come from TCGA and GEO databases and are divided into training and validation cohorts. Immune genes were selected which show significantly association with prognosis. Results. Among 1647 immune genes, a 17 IRGPs model was built which was significantly associated with OS in the training cohort. In the training and validation data set, the IRGPs model divided patients into high-risk groups and low-risk groups, and the prognosis of the high-risk group was significantly worse(P＜0.001). Univariate and multivariate Cox proportional hazard analysis confirmed the feasibility of this model. Functional analysis confirmed that multiple tumor progression and stem cell growth-related pathways in high-risk groups were up-regulated. T cells regulatory and Macrophage M0 were significantly highly expressed in the high-risk group. Conclusion. We successfully constructed an IRGPs model that can predict the prognosis of COAD, which provides new insights into the treatment strategy of COAD.

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Section: Discussionmentioning

confidence: 99%

Establishment of an immune-related gene pairs model to predict colon adenocarcinoma prognosis

Luo

Liu

Wang

et al. 2020

Preprint

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“…Treg cells have been shown to be associated with poor prognosis [33]. Activated TGF-β existed widely in the TME, and inhibited the activity of NK cells and CTLs, the proliferation of Teff cells and the production of cytokines, as well as inhibited the differentiation of Teff cells into Th1 and Th17 cells, aiding the migration and metastasis of tumour cells [34]. Moreover, current research has determined that CCR8+ regulatory T cells are drivers of immunosuppression, which can help the immune escape of tumours [35].…”

Section: Correlations Between the Expression Levels Of Syt4 And Markementioning

confidence: 99%

Prognostic and immune roles of synaptotagmin-4 in gastric cancer and brain lower-grade glioma

Jiang

Zhu

Jiang

et al. 2020

Preprint

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Background Synaptotagmins (SYTs) are a family of proteins whose primary function is serving as a calcium sensor in vesicle transport and exocytosis, playing an important role in the function of immune cells. There is also a close relationship between immune cells and tumours. SYT4 is one molecule involved in this relationship, but the relationship between SYT4 and cancer remains unclear. Therefore, we hypothesize that SYT4 can affect the prognosis of cancer, and may be related to immune cells. Methods The following databases were used to study the immunological and prognostic role of SYT4 in cancers: Oncomine, Kaplan-Meier plotter, The Human Protein Atlas, CCLE, GEPIA2, TIMER, and CGGA. Results SYT4 expressions were lower in many cancers than in normal tissues. Specifically in gastric cancer and lower-grade gliomas, SYT4 played a protective and harmful role, respectively. Moreover, a difference between SYT4 expression and the levels of immune infiltration existed in stomach adenocarcinoma (STAD) and brain lower-grade glioma (LGG). In addition, we found that the relationship between markers of monocytes, M1 and M2 macrophages, tumour-associated macrophages (TAMs), Treg cells, B lymphocytes, dendritic cells (DCs) and SYT4 expression was opposite in STAD and LGG. Conclusions The effect of SYT4 on the prognosis of patients with STAD and LGG was opposite. And SYT4 has different effects on immune infiltration in these two tumours. Therefore, SYT4 might be a potential prognostic and tumour immune-related biomarker in STAD and LGG.

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“…The innate and adaptive immune response of canines is also comparable to that of humans. Major subsets of the dog immune system are well characterized to have significant homology to their corresponding the consumption of IL-2, and the production of immunosuppressive metabolites [27]. Since Treg infiltration has already been extensively studied in mammary canine tumors [28,29], we focused on the expression of other T lymphocyte-associated factors in canine mammary tumors.…”

Section: Introductionmentioning

confidence: 99%

The Expression of Selected Factors Related to T Lymphocyte Activity in Canine Mammary Tumors

Bujak

Szopa

Pingwara

et al. 2020

IJMS

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Crosstalk between neoplastic and immune cells in the tumor microenvironment (TME) influences the progression of disease in human and canine cancer patients. Given that canine mammary tumors are a useful model to study breast cancer biology, we aimed to evaluate the expression of genes associated with T lymphocyte activity in benign, malignant, and metastatic canine mammary tumors. Interestingly, metastatic tumors exhibit increased expression of CXCR3, CCR2, IL-4, IL-12p40, and IL-17. In particular, we focused on IL-17, a key interleukin associated with the Th17 lymphocyte phenotype. Th17 cells have been shown to play a contradictory role in tumor immunity. Although IL-17 showed a high expression in the metastatic tumors, the expression of RORγt, a crucial transcription factor for Th17 differentiation was barely detected. We further investigated IL-17 expression using immunohistochemistry, through which we confirmed the increased expression of this interleukin in malignant and metastatic mammary tumors. Finally, we compared the plasma levels of IL-17 in healthy and malignant mammary tumor-bearing dogs using ELISA but found no differences between the groups. Our data indicate that the IL-17 in metastatic tumors may be produced by other cell types, but not by Th17 lymphocytes. Overall, our results broaden the available knowledge on the interactions in canine mammary tumors and provide insight into the development of new therapeutic strategies, with potential benefits for human immune oncology.

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Contribution of regulatory T cells to cancer: A review

Cited by 157 publications

References 100 publications

Establishment of an immune-related gene pairs model to predict colon adenocarcinoma prognosis

Establishment of an immune-related gene pairs model to predict colon adenocarcinoma prognosis

Prognostic and immune roles of synaptotagmin-4 in gastric cancer and brain lower-grade glioma

The Expression of Selected Factors Related to T Lymphocyte Activity in Canine Mammary Tumors

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