Knee radiosynovectomy with 153Sm-hydroxyapatite compared to 90Y-hydroxyapatite: initial results of a prospective trial

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

“…Forty‐three studies had sample sizes > 20 knees 5–47 . Sixty‐eight studies were defined as small and were not discussed further.…”

Present and future of target therapies and theranostics: refining traditions and exploring new frontiers—highlights from annals of Nuclear Medicine 2021

“…Albeit nuclear medicine treatments have been mainly engaged in oncology, some benign conditions, including hyperthyroidism and osteoarthropathy, may benefit from radionuclide therapy [49,50]. Santos et al [19] reported less hemarthrosis episodes using [ 153 Sm]Sm-HyA compared to the more commonly employed [ 90 Y]Y-HyA, in haemophiliac patients. Liepe and Baehr [20] accounted the effectiveness of erbium-169-based-one of the most interesting beta-emitting isotopes [51]-radiosynovectomy in thumb basal joint arthritis.…”

“…Santos et al [19] prospectively assessed the efficacy and safety of knee radiosynovectomy with [ 153 Sm]Sm-Hydroxyapatite (HyA) in comparison to the more commonly used [ 90 Y]Y-HyA in haemophiliac patients to prevent secondary arthropathy. Knee radiosynovectomy with [ 153 Sm]Sm-HyA was safe and the reduction of hemarthrosis episodes after 12 months was higher compared to patients treated with [ 90 Y]HyA (87.5% vs 50%), especially in adults/ adolescents.…”