Knee Osteoarthritis—How Close Are We to Disease-Modifying Treatment: Emphasis on Metabolic Type Knee Osteoarthritis

Lambova, Sevdalina Nikolova

doi:10.3390/life13010140

Cited by 4 publications

(2 citation statements)

References 38 publications

(51 reference statements)

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“…Obesity is associated with a change in phenotype from M2 macrophages to classic M1-activated macrophages that release pro-inflammatory cytokines [ 41 ]. These complex mechanisms further involve other pathological conditions associated with obesity in the context of metabolic syndrome, such as dyslipidemia and insulin resistance [ 39 , 42 ].…”

Section: Obesity Metabolic Syndrome and Knee Oamentioning

confidence: 99%

Obesity-Related Knee Osteoarthritis—Current Concepts

Shumnalieva,

Kotov,

Monov

2023

Life

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The knee is the joint most frequently involved in osteoarthritis and represents a significant contributor to patient morbidity and impaired functional status. Major risk factors include genetics, age, sex, mechanical load and obesity/metabolic syndrome. Recent studies highlighted the role of obesity and metabolic syndrome in the pathogenesis of knee osteoarthritis not simply through increased mechanical loading but the systemic effects of obesity-induced inflammation. The current concept of knee osteoarthritis is that of a ‘whole joint disease’, which highlights the involvement not only of articular cartilage but also the synovium, subchondral bone, ligaments and muscles. Obesity and metabolic syndrome are associated with higher levels of pro-inflammatory cytokines, increased production of adipokines with both protective and destructive effects on articular cartilage, an up-regulation of proteolytic enzymes such as matrix metalloproteinases and aggrecanases and an increase in free fatty acids and reactive oxygen species induced by dyslipidemia. These findings underscore that the adequate management of knee osteoarthritis needs to include an optimization of body weight and a beneficial mobility regimen. The possible introduction of pharmacological therapy targeting specific molecules involved in the pathogenesis of obesity-related osteoarthritis will likely also be considered in future therapeutic strategies, including personalized treatment approaches.

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Section: Obesity Metabolic Syndrome and Knee Oamentioning

confidence: 99%

Obesity-Related Knee Osteoarthritis—Current Concepts

Shumnalieva,

Kotov,

Monov

2023

Life

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“…Monitoring synovial joint mobility is critical for identifying and controlling joint-related issues such as osteoarthritis, rheumatoid arthritis, and other inflammatory joint illnesses [ 5 , 6 ]. Understanding the various kinds of synovial joints and their roles allows clinicians and doctors to create successful therapy strategies for patients with joint-related illnesses [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

New Method for Reduced-Number IMU Estimation in Observing Human Joint Motion

Hoang

Shiao

2023

Sensors

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Observation of human joint motion plays an important role in many fields. The results of the human links can provide information about musculoskeletal parameters. Some devices can track real-time joint movement in the human body during essential daily activities, sports, and rehabilitation with memory for storing the information concerning the body. Based on the algorithm for signal features, the collected data can reveal the conditions of multiple physical and mental health issues. This study proposes a novel method for monitoring human joint motion at a low cost. We propose a mathematical model to analyze and simulate the joint motion of a human body. The model can be applied to an Inertial Measurement Unit (IMU) device for tracking dynamic joint motion of a human. Finally, the combination of image-processing technology was used to verify the results of model estimation. Moreover, the verification showed that the proposed method can estimate joint motions properly with reduced-number IMUs.

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Primary osteoarthritis of the lumbar spine presenting as chronic low back pain or sciatica or both (prolapsed lumber disc syndrome): establishing its cause, pathogenesis, and treatment: A randomized case-control study

Agrawal

2023

IJOS

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: The objectives of this study were to compare three scores, Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Oswestry Disability Index (ODI) for low back pain, and Visual Analogue Scale (VAS) Vertical Version at the beginning and end point in two, Trial (G1), and Control (G2) groups of Primary Osteoarthritis of lumbar spine patients.The inner nucleus pulposus may rupture out from the annulus as the disc continues to degrade or as the spine continues to be stressed. This is a herniated or burst disc. The nerve roots that are immediately behind the disc space may then be pressed by the disc material fragments. This may result in discomfort, frailty, numbness, or alterations in feeling.: Understanding the causes, pathophysiology, and treatments for prolapsed lumber disc syndrome, which presents as primary osteoarthritis of the lumbar spine and causes chronic low back pain, sciatica, or both.: In this study, the total number of patients were 150, in G1 - 100, and G2 - 50. G1 received the hypothesized treatment, Contracture Correction Therapy (CCT), while G2 did “No Therapy”. WOMAC determination was done by the questionnaire; ODI by modified Oswestry Low Back pain disability questionnaire and VAS by Visual Analogue Scale Vertical Version, all at 0, 6, 12, and 24 weeks. The CCT consisted of 1. Immobilization of the spine. 2. Passive and active extension of the spine. 3. Three therapeutic rituals and 4. Advice to avoid stooping.: The CCT receiving was associated with much recovery (P <0.00) while non-receiving with much less (P =0.00). In G1 WOMAC decreased from 54.29 to 0.00; ODI from 51.82 to 1.80; VAS rose from 37.56 to 100 (rise indicates betterment) P= 0.00. In G2 WOMAC lowered from 56.40 to 4.08; ODI from 65.10 to 6.0; VAS rose from 34.40 to 81.00. Relief in symptoms was similar.: The cause, pathogenesis, and treatment are deficient full extension, I.V. joint capsule contracture formation, and extension of the lumbar spine respectively.

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Knee Osteoarthritis—How Close Are We to Disease-Modifying Treatment: Emphasis on Metabolic Type Knee Osteoarthritis

Abstract: Osteoarthritis (OA) is a whole-joint disease that affects cartilage, bone, and synovium as well as ligaments, menisci, and muscles [...]

Cited by 4 publications

References 38 publications

Obesity-Related Knee Osteoarthritis—Current Concepts

Obesity-Related Knee Osteoarthritis—Current Concepts

New Method for Reduced-Number IMU Estimation in Observing Human Joint Motion

Primary osteoarthritis of the lumbar spine presenting as chronic low back pain or sciatica or both (prolapsed lumber disc syndrome): establishing its cause, pathogenesis, and treatment: A randomized case-control study

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