Knee Laxity in Symptomatic Osteoarthritis

Brage, Michael E.; Draganich, Louis F.; Pottenger, Lawrence A.; Curran, James F.

doi:10.1097/00003086-199407000-00028

Cited by 75 publications

(78 citation statements)

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“…Casino et al [11] found varus-valgus laxity decreased in full extension after TKA, while others found no difference in laxity [42,46]. We believe these results may differ from ours (laxity increases after TKA) because previous studies used data from osteoarthritic knees, which is known to diminish varus-valgus laxity [9], and did not measure the load applied to the knee. In contrast to laxity, little research exists on the effect of TKA on terminal stiffness of the knee.…”

Section: Discussioncontrasting

confidence: 56%

“…While the ideal loads that should be used to assess knee laxity and stiffness during a TKA are unknown, this load was chosen because it ensured we would be able to measure the terminal stiffness of the knee, encompassed a range used to biomechanically evaluate knee stability [9,31,32,36,51], and was the maximum load that experienced surgeons in this study believed they could use on a patient during TKA. The specimen's foot was placed in a modified Alvarado boot (Zimmer) [48] while the femur was constrained by a Lane bone clamp held by the surgeon.…”

mentioning

confidence: 99%

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Is There a Gold Standard for TKA Tibial Component Rotational Alignment?

Hutter

Granger

Beal

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Section: Discussioncontrasting

confidence: 56%

mentioning

confidence: 99%

Is There a Gold Standard for TKA Tibial Component Rotational Alignment?

Hutter

Granger

Beal

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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show abstract

“…However, these measurements were performed before surgery or bone resection [1,3,9,16,20]. Therefore, surgeons try to correct intraoperative imbalance by releasing the medial soft tissues.…”

Section: Discussionmentioning

confidence: 99%

Lateral Soft Tissue Laxity Increases but Medial Laxity Does Not Contract With Varus Deformity in Total Knee Arthroplasty

Okamoto

Okazaki

Mitsuyasu

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…In an earlier study, Wada et al (11) reported increased AP knee laxity in early-stage human OA followed by a decrease in laxity, where knees with advanced OA were less lax than normal control knees. Based on the data from both studies, Wada suggested that the trend toward increased AP joint stiffness in late-stage disease (3,11,48) was attributable to intercondylar osteophyte formation, along with femorotibial lipping, and that this bone remodeling event increased contact between joint surfaces, which compensated for early-stage AP laxity. Shepstone et al (23) also proposed that remodeling of the intercondylar notch is an event secondary to the onset of OA.…”

Section: Discussionmentioning

confidence: 99%

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

Quasnichka¹,

Anderson-MacKenzie²,

Tarlton³

et al. 2005

Arthritis & Rheumatism

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Objective. The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary OA. Additionally, femoral notch narrowing at the anterior cruciate ligament (ACL) insertion site is associated with disease severity, but it is unknown whether ligament deterioration precedes or follows osteophyte formation. We examined cruciate ligament mechanics and metabolism and the intercondylar notch width in OAprone Dunkin-Hartley (DH) guinea pigs at ages up to and including the age at OA onset (24 weeks), and compared the data with those in age-matched controls (Bristol strain 2 [BS2] guinea pigs).Methods. Guinea pigs were assessed at 3, 6, 9, 12, 16, 20, 24, and 36 weeks of age. ACLs were mechanically tested, and the intercondylar notch width index (NWI) was determined. Cruciate ligament metabolism was determined by measuring the following markers of collagen turnover: matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 2, C-terminal type I procollagen propeptide (PICP), and the immature collagen-derived crosslink dihydroxylysinonorleucine (DHLNL).Results. DH guinea pigs had significantly laxer ACLs than did BS2 guinea pigs, at 12, 16, and 24 weeks. We observed elevated levels of pro and active MMP-2, PICP, and DHLNL in the cruciate ligaments of DH animals at most ages, compared with BS2 guinea pigs. The NWI in DH animals was significantly lower than that in BS2 guinea pigs at 24 and 36 weeks.Conclusion. In DH guinea pigs, laxer ACLs, which are associated with increased collagen turnover, may cause joint instability and predispose these animals to the early onset of OA. Decreased intercondylar notch width in the DH animals indicates that bone remodeling at the ACL insertion site is a response to elevated ACL laxity.

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Knee Laxity in Symptomatic Osteoarthritis

Cited by 75 publications

References 0 publications

Is There a Gold Standard for TKA Tibial Component Rotational Alignment?

Is There a Gold Standard for TKA Tibial Component Rotational Alignment?

Lateral Soft Tissue Laxity Increases but Medial Laxity Does Not Contract With Varus Deformity in Total Knee Arthroplasty

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis

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