Klinische und experimentelle Untersuchungen �ber die photodynamische Wirksamkeit von Phenothiazinderivaten, insbesondere von Megaphen

Role of <i>in viv</i><i>o</i>- and <i>in vitr</i><i>o</i>-formed Decomposition Products of Sulfanilamides and Phenothiazines in Photoallergy; Relationship of Spectrophotometric Findings to <i>in vivo</i> Reactions

“…Schulz et al feel the resulting combined substance to be the final cczcmatogen (22). We found, however (Table V), that the ad dition of albumin to the drug (Largactil, Phenergan or sulfanila mide) before in vitro irradiation made no apparent difference in the test results.…”

“…Sidi et al, Schulz et al as well as E pstein and R o w e previously demon strated the possibility of such photocross-sensitivitics, most suggest ing the similarity between decomposition products as a possible explanation for the phenomenon (10,11,22,25). Patient [20], however, although reacting positively to in vitro irradiated Largactil, reacted negatively to in vitro irradiated Phenergan.…”

“…The 'Esidrcx' and 'Gantanol' cases were plain patch tested with in vitro irradiated 1% sulfanilamide in pure water and in 1% albumin. In addition, they were both patch tested with p-hydroxylamino-benzenesulfonamidc (PHABSA), one of the oxid ation products assumed to be the allergen formed by the action of light upon sulfanil amide (22).…”

Photopatch test method: influence of type of irradiation and value of day‐7 reading

“…In contrast to phototoxic reactions, the pathogenesis of PACD is thought to be a form of cell‐mediated hypersensitivity and ultraviolet (UV) radiation is required to both induce and elicit the immune response. The concept of photopatch testing for the diagnosis of PACD and the development of its technique started in the 1950s (1, 2). Some of the first photoallergens uncovered by this technique were the halogenated salicylanilides used as antimicrobials in cosmetics and deodorant soaps (3).…”

Personnel radiation dosimetry in drug photosensitivity: field study of patients on phenothiazine therapy

“…It has already been put to field trial with promising results by Challoner et al (1976) in normal persons exposed to different amounts of sunlight. We here record a study with the dosimeters on patients taking phenothiazines, which are known photosensitizers (Labhardt, 1954;Schulz, Wiskemann & Wulf, 1956). Our aim was to assess the value of the dosimeter under field conditions within a closed community in which a high prevalence of photosensitivity symptoms would be expected, to correlate these symptoms with solar exposure and to compare various methods of assessing solar exposure.…”