Personnel radiation dosimetry in drug photosensitivity: field study of patients on phenothiazine therapy

Corbett, Mandy; Davis, A.; Magnus, I.A.

doi:10.1111/j.1365-2133.1978.tb07331.x

Cited by 22 publications

(10 citation statements)

References 7 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I have tried a few experiments of this type with chlorpromazine without success, but because the Salmonella test has not been successful in detecting as mutagens a number of the important halogenated carcinogens (16) Several studies on photo-induced skin sensitization in mice with a series of phenothiazine tranquilizers suggest that only the chlorinated derivatives produce significant toxic effect (12,17). It is also interesting that the most effective photomutagen, chlorpromazine (Table 1), is also the phenothiazine that has most often been reported to produce photoreactions in humans, and, for a given amount of light exposure, patients taking chlorpromazine suffer more photosensitized reactions (18). Chlorpromazine is also the phenothiazine that has most definitely been associated with cataract formation (19), which may suggest that the mechanisms of photomutagenesis and cataractogenesis are similar.…”

Section: Discussionmentioning

confidence: 99%

Photomutagenesis by chlorinated phenothiazine tranquilizers.

Jose¹

1979

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Phenothiazine tranquilizers are widely used pharmaceuticals that have been associated with side effects, such as formation of cataracts, that seem related to light exposure. Because patients may use them over extensive time periods, it is important to determine what deleterious cellular effects these drugs may cause and, if possible, to select or design drugs that do not cause such effects. The results reported here demonstrate that chlorinated phenothiazine drugs can be photoactivated to mutagenic species, whereas the nonchlorinated analogues do not possess this characteristic. None of the phenothiazines tested is mutagenic in the dark. Mutagenicity was observed only in strains of Salmonella typhimurium that lacked excision repair of DNA, and the mutagenicity was elevated in strains that contained the plasmid pKM101, which may enhance error-prone repair.

show abstract

Section: Discussionmentioning

confidence: 99%

Photomutagenesis by chlorinated phenothiazine tranquilizers.

Jose¹

1979

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Their testimonials about a treatment should therefore not be taken too literally. Even in circumstances where hours of solar exposure are recorded in an institution by trained personnel (nursing staff), recorded hours of exposure only agreed moderately well with polysulphone film measurements (r = o-32) (Corbett et al, 1978).…”

Section: The Diary Record Of Solar Exposurementioning

confidence: 83%

“…Although statistically significant results were obtained with chloroquine and with /i-carotene at the lower dose for some symptoms, none of the absolute differences in the symptom scores between the treatment groups was very great. It therefore seems likely that the treatments are only moderately active if at all; with the number of patients studied there was a 90",, chance of detecting a 60",, improvement in symptoms by simple statistical comparisons (Corbett et al, 1978). A larger trial could yield a closer estimate of treatment efficacy, but greater precision seems misplaced for such a marginal effect.…”

Section: Discussionmentioning

confidence: 99%

“…Badges were worn for the 5 weekdays and changed for a new badge at weekends. This avoided the over-exposure of badges noted earlier (Corbett, Davis & Magnus, 1978) since indoor workers tend to be exposed to UVR mainly during weekend leisure activities {Challoner et al, 1978). An estimate of the dose of UVR received was obtained by the change in optical absorbance of the polysulphone film (Davis, Dean and Diffey, 1976).…”

Section: Measurement Of Patients' Uvr Exposurementioning

confidence: 99%

See 1 more Smart Citation

Controlled therapeutic trials in polymorphic light eruption

et al. 1982

Self Cite

View full text Add to dashboard Cite

A series of controlled trials of treatments for polymorphic light eruption (PLE) with oral beta-carotene, ketoprofen and chloroquine, and topical benzimidazole sunscreen cream is described. Clinical features were recorded using diary cards filled out by the patients, and exposure to UVR was measured individually in all patients with film badges. Symptoms were found to be dependent on exposure. None of the treatments proved very effective, but beta-carotene seemed to give significant slight protection against irritation and erythema, though this was not confirmed in a repeat study using a higher dose. Chloroquine seemed to protect slightly against irritation. As the degree of improvement with chloroquine and beta carotene is quite small, equivalent to a protection factor of 2, it is arguable whether these treatments as used here are worthwhile and in the case of chloroquine, with its risk of adverse side effects, whether it is justifiable. Other treatment and dose regimes are possible and further trials seem worthwhile. Our studies have helped to define the special difficulties in collecting objective data in PLE and should improve the methods for assessing treatment in the photodermatoses.

show abstract

“…In the same period, Corbett et al . (*) took note of adverse effects from photosensitizing drugs because at that time about 60 oral approved drugs in the UK appeared to cause photosensitivity. PE of patients treated with phenothiazine was monitored, and adverse effects, the time spent outdoors and the time under the sun were recorded using diaries.…”

Section: Chronological Overviewmentioning

confidence: 99%

Review on Nonoccupational Personal Solar UV Exposure Measurements

Schmalwieser

Siani

2018

Photochem & Photobiology

View full text Add to dashboard Cite

Solar ultraviolet (UV) radiation follows people during their whole life. Exposure to UV radiation is vital but holds serious risks, too. The quantification of human UV exposure is a complex issue. UV exposure is directly related to incoming UV radiation as well as to a variety of factors such as the orientation of the exposed anatomical site with respect to the sun and the duration of exposure. The use of badge-sensors allows assessing the UV exposure of differently oriented body sites. Such UV devices have been available for over 40 years, and a variety of measuring campaigns have been undertaken since then. This study provides an overview of those studies which reported measurements of the personal UV exposure (PE) during outdoor activities of people not related to their occupation. This overview is given chronologically to show the progress of knowledge in this research and is given with respect to different activities. Special focus is put on the ratio of personal exposure to ambient UV radiation. This ratio, when given as a function of solar elevation, allows estimating PE at any other location or date if ambient UV radiation is known.

show abstract

Personnel radiation dosimetry in drug photosensitivity: field study of patients on phenothiazine therapy

Cited by 22 publications

References 7 publications

Photomutagenesis by chlorinated phenothiazine tranquilizers.

Photomutagenesis by chlorinated phenothiazine tranquilizers.

Controlled therapeutic trials in polymorphic light eruption

Review on Nonoccupational Personal Solar UV Exposure Measurements

Contact Info

Product

Resources

About