Klinische Prüfung des Uroselectans

Lichtenberg, Alexander von; Swick, Moses

doi:10.1007/bf01875122

Cited by 59 publications

(2 citation statements)

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“…Lichtenberg and Swick (1929) suggested tentatively that the organic compounds of iodine might be of service in estimating kidney function, but artefacts, which make it dangerous to estimate renal function from the intensity of the radiographic shadows produced during intravenous urography, have been emphasized repeatedly (Lichtenberg and Swick (1929); Heckenbach (1930); Lichtenberg (1931); Lindenfeld (1932); Lauber (1932); Olivet (1933); Chabanier and Lobo-Onell (1933);Hefke (1934)). It is generally agreed also that renal insufficiency prevents good radiographic visualization of the urinary tract by means of intravenous urography (Heritage (1930) ;Jezler (1931) ; Lichtenberg (1931); Pask (1933), etc.).…”

Section: Methodsmentioning

confidence: 99%

Simultaneous Plasma Clearances of Creatinine and Certain Organic Compounds of Iodine in Relation to Human Kidney Function 1

Landis

Elsom²,

Bott³

et al. 1936

J. Clin. Invest.

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Creatinine is excreted by the human kidney in higher concentration, relative to plasma level, than any other normal urinary constituent. The exceptionally rapid elimination of certain organic compounds of iodine now used in excretion urography suggested that these substances might be excreted even more rapidly than creatinine. The observations described below compare the plasma clearances of urea, creatinine and organic iodine (skiodan, neoskiodan or diodrast, and hippuran 2) by normal human subjects. Skiodan was cleared from plasma at approximately the same rate as creatinine; neoskiodan and hippuran several times more rapidly than creatinine. Even in the presence of renal disease hippuran clearances were significantly greater than creatinine clearances, without relation to the type of renal lesion. PROCEDUREAll subjects omitted breakfast on the day of study and were recumbent during the clearance periods. To a group of ten 3 subjects with normal or almost normal kidney function (Table I) water was given in different amounts to produce a wide range of diuresis. To a second group of seventeen patients with renal insufficiency water was given, with two exceptions (Cases 9 and 11, Table II), at the rate of 200 cc. hourly from three hours before the beginning of the first clearance period to the end of the last clearance period.Creatinine was administered orally in doses of 1 The expenses of this investigation were in large part paid by a grant from the Commonwealth Fund.2 Skiodan, sodium mono-iodo methane sulphonate, contains 52 per cent of iodine. Neoskiodan or diodrast, 3:5 di-iodo-4-pyridon-N-acetic acid diethanolamine, contains 50 per cent iodine. Hippuran, sodium ortho-iodo-hippurate, contains 34.4 per cent iodine, when allowance is made for moisture in the powdered substance.3 One subject received neoskiodan and hippuran.3 or 5 grams in the water given one hour before the beginning of the first clearance period. Skiodan and neoskiodan were given intravenously in doses of 13.0 cc. (iodine 2.70 grams) and 20.0 cc. (iodine 3.50 grams) of the respective commercial solutions, approximately fifteen minutes before the beginning of the first clearance period to allow for thorough mixing in the blood stream. Hippuran was administered orally in doses of 12 grams dissolved with the creatinine in the water taken one hour prior to the beginning of the first clearance period. Urine was collected over two periods, each approximately one hour in duration, and timed to the nearest minute. In order to estimate the percentage of the entire dose eliminated in a given period, the urine formed in the interval between the administration of the organic iodine compound and the beginning of the first period was also saved. Venous blood samples were collected (using lithium oxalate as anti-coagulant) at the beginning and end of each clearance period so that average plasma concentrations of urea, creatinine and iodine could be determined. The blood was centrifuged within ten minutes after it was drawn from the vein to avoid errors ari...

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Section: Methodsmentioning

confidence: 99%

Simultaneous Plasma Clearances of Creatinine and Certain Organic Compounds of Iodine in Relation to Human Kidney Function 1

Landis

Elsom²,

Bott³

et al. 1936

J. Clin. Invest.

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“…Renal excretion of the substance by a normal kidney, measured as precipitable substance or as iodine, was rapid in contrast to that in kidneys with impaired excretory function. Most promising results were reported in 1929 [30] and the use of Uroselectan and other polyiodinated derivatives provided by the ScheringKahlbaum AG became a general therapeutic principle after 1930. Figure 7 gives reproductions of one of the first urograms obtained by Swick with Uroselectan.…”

Section: Excretion Urographymentioning

confidence: 99%

Pioneer IMephrologists of Berlin

Hierholzer¹,

Winau

1992

Am J Nephrol

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Intravenous Urography by Means of the Sodium Salt of 5-Iodo2-Pyridon-N-Acetic Acid

Swick¹

1930

JAMA

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In 1923 Rowntree and his co-workers 1 of the Mayo Clinic were the first to attempt to visualize the urinary tract by means of the intravenous injection of a 10 per cent solution of sodium iodide and also by the oral administration of that salt. The urinary bladder, and in some cases the pelvis and ureter, could be visualized.The following year Rosenstein and von Lichtenberg 2 reported at the urologic congress in Berlin their results, repeating the work of Rowntree and his co-workers with sodium iodide but in conjunction with perirenal pneumoradiography.In the same year Volkmann 3 reported his observations with the use of different halogen compounds; he found the intravenous injection of a 10 per cent solution of sodium iodide to be best.In 1927 Lenarduzzi and Pecco,4 tying off the ureter and injecting sodium iodide intravenously in animals, obtained positive roentgenograms of the kidney, pelvis and ureter.Hryntschak5 at the urologic congress in Berlin in 1928 and in a publication in 1929 6 reported his results with the use of a large series of bromine and iodine compounds, aromatic in nature, carrying out about 200 animal experiments. Neither the names nor the chemical formulas of the substances used by him are stated. In his publication the only detail of the chemical composition of three of them applied and numbered 13, 27 and 48 is that the first two were iodine and the last a bromine compound. In some of his experiments he simultaneously used an adjuvant, such as caffeine, urea, pituitary extract and atropine, to influence excre¬ tion and the dynamics of the pelvis and ureter. He obtained some positive results in animals and in a female patient. In his conclusions he stated that although, two and a half years ago, he had been able to obtain useful intravenous pyelograms in a few cases, the method had by no means met the conditions set forth by him. He, however, expressed the hope of accomplishing his aims by continued investigations.

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Klinische Prüfung des Uroselectans

Cited by 59 publications

References 0 publications

Simultaneous Plasma Clearances of Creatinine and Certain Organic Compounds of Iodine in Relation to Human Kidney Function 1

Simultaneous Plasma Clearances of Creatinine and Certain Organic Compounds of Iodine in Relation to Human Kidney Function 1

Pioneer IMephrologists of Berlin

Intravenous Urography by Means of the Sodium Salt of 5-Iodo2-Pyridon-N-Acetic Acid

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