Klinefelter Syndrome and Non-Hodgkin Lymphoma

Humphreys, Mervyn; Lavery, Philip; Morris, Curly; Nevin, N. C.

doi:10.1016/s0165-4608(96)00386-x

Cited by 13 publications

(4 citation statements)

References 21 publications

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“…Swerdlow et al suggested that this relationship is due to the over-activation of an oncogene on the X chromosome that evokes escape of X inactivation, and that the risk of lymphoma was especially high in males who have multiple X chromosomes [ 13 ]. There are no available data on whether immunologic problems develop more frequently in patients with Klinefelter syndrome than in those with normal karyotype; however, several reports suggested that the prevalence of autoimmune diseases, including systemic lupus erythematosus, may be elevated in males with Klinefelter syndrome [ 14 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

Angioimmunoblastic T-Cell Lymphoma in a Patient with Klinefelter Syndrome

Park

Bae

et al. 2016

Am J Case Rep

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Patient: Male, 61Final Diagnosis: AITL in Klinefelter syndromeSymptoms: —Medication: —Clinical Procedure: ChemotherapySpecialty: HematologyObjective:Rare diseaseBackground:Although patients with Klinefelter syndrome have elevated risk and incidence rates for several solid cancers, reports on the incidence of hematological malignancies have been equivocal.Case Report:We report a patient diagnosed with angioimmunoblastic T-cell lymphoma in whom Klinefelter syndrome was newly detected. Moreover, we discuss the development of a variety of lymphomas in patients with Klinefelter syndrome.Conclusions:This is the first case describing angioimmunoblastic T-cell lymphoma in a patient with Klinefelter syndrome who was treated with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Angioimmunoblastic T-Cell Lymphoma in a Patient with Klinefelter Syndrome

Park

Bae

et al. 2016

Am J Case Rep

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“…People with Klinefelter syndrome tend to have a higher incidence of malignant soft tissue tumors. 14,15 Whether there is an additive effect to this syndrome involving Dacron and the aneurysm is speculative as well.…”

Section: Discussionmentioning

confidence: 99%

Hemangiosarcoma After Endovascular Aortic Aneurysm Repair

Umscheid

Rouhani

et al. 2007

Journal of Endovascular Therapy

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“…In fact, a number of XYY and XXY males with hematological malignancies have been reported, most of them with leukemia or myelodysplastic syndromes (54). Conversely, only sporadic cases with NHL have been described (55–59). Previous results of our laboratory in a series of patients with hematological disorders (14) did not find differences when the incidence of sex chromosome abnormalities was compared with that of the overall population, indicating that this type of CCA does not predispose to hematological malignancies.…”

Section: Discussionmentioning

confidence: 99%