New chromosome abnormalities and lack of <i>BCL‐6</i> gene rearrangements in Argentinean diffuse large B‐cell lymphomas

Cerretini, Roxana; Noriega, Maria Fernanda; Narbaitz, Marina; Slavutsky, Irma

doi:10.1111/j.1600-0609.2005.00616.x

Cited by 10 publications

(7 citation statements)

References 57 publications

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“…Consistent with this notion, deletions of 5q13-14 have been reported in a distinct subset of human diffuse large B cell lymphomas (DLBCL) lacking BCL6 rearrangements (Cerretini et al, 2006). Moreover, global expression profiling to distinguish Burkitt lymphoma from DLBCL identified high SSBP2 expression in Burkitt lymphoma compared to DLBCL(Dave et al, 2004).…”

Section: Discussionmentioning

confidence: 59%

SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability

et al. 2010

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SSBP proteins bind and stabilize transcriptional cofactor Lim Domain Binding protein1 (LDB1) from proteosomal degradation to promote tissue specific transcription through an evolutionarily conserved pathway. The human SSBP2 gene was isolated as a candidate tumor suppressor from a critical region of loss in chromosome 5q14.1. By gene targeting, we demonstrate increased predisposition to B cell lymphomas and carcinomas in Ssbp2−/− mice. Remarkably, loss of Ssbp2 causes increased LDB1 turnover in the thymus, a pathway exploited in Trp53−/− Ssbp2−/− mice to develop highly aggressive, immature thymic lymphomas. Using T cell differentiation as a model, we report a stage specific up regulation of Ssbp2 expression which in turn regulates LDB1 turnover under physiological conditions. Furthermore, transcript levels of pTα, a target of LDB1 containing complex, and a critical regulator T cell differentiation is reduced in Ssbp2−/− immature thymocytes. Our findings suggest disruption of the SSBP2 regulated pathways may be an infrequent but critical step in malignant transformation of multiple tissues.

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Section: Discussionmentioning

confidence: 59%

SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability

et al. 2010

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“…The incidence of t(11; 14)(q13;q32) in MCL was 91.9%, ranging from 66.7 to 100% (Bigoni et al, 1996;Siebert et al, 1998;Li et al, 1999;Frater et al, 2001;Belaud-Rotureau et al, 2002;Kodet et al, 2003;Jarosova et al, 2004). In DLBCL, the 14; 18 translocation was found in 16% of the cases (range: 13.1 to 20%) (Huang et al, 2002;Barrans et al, 2003;Iqbal et al, 2004;Cerretini et al, 2006). Gozzetti et al (2002) used dual color FISH with an IGH probe to determine the rate of cryptic translocations and identify the chromosomal partners among 51 selected Bcell NHL patients.…”

Section: Discussionmentioning

confidence: 99%

Molecular cytogenetics of IGH rearrangements in non-Hodgkin B-cell lymphoma

Bernicot

Douet‐Guilbert²,

Bris³

et al. 2007

Cytogenet Genome Res

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Rearrangements involving the IGH gene have been identified in about 50% of non-Hodgkin B-cell lymphomas (NHLs) and correlated to clinically relevant subgroups. However, the detection rate largely varied with the technique used. We analyzed the incidence of IGH rearrangements using several fluorescence in situ hybridization (FISH) techniques on metaphases obtained from 96 patients with nodal NHL. An IGH rearrangement was identified in 71 cases (74%). A t(14;18)(q32;q21) was found in 37 of the 42 follicular lymphomas (88.1%) studied and a t(11;14)(q13;q32) in 12 of the 14 mantle cell lymphomas (85.7%). IGH rearrangements were identified in 21 of the 40 diffuse large B-cell lymphomas (52.5%), including seven t(14;18)(q32;q21) and four t(3;14)(q27;q32). Conventional cytogenetics was uninformative in several cases. However, the complemented analysis using 24-color FISH, chromosomal whole paints, telomeric probes and locus specific identifiers enabled us to characterize complex and/or masked IGH translocations in follicular lymphomas and mantle cell lymphomas and to identify all the chromosomal partners involved in IGH rearrangements in diffuse large B-cell lymphomas. This study shows the interest of using metaphase FISH in addition to conventional cytogenetics. Following banding techniques, FISH with the IGH dual color probe can be the first approach in NHL, after which chromosome painting and 24-color FISH can be used to identify the chromosomal partners involved in IGH rearrangements. The identification of these genes is of utmost importance for a better understanding of the molecular mechanisms involved in the genesis of lymphoma.

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“…Diffuse large B‐cell lymphoma (DLBCL) is the most common form of non‐Hodgkin lymphoma, accounting for 30–40% of all adult non‐Hodgkin lymphoma cases in Western countries. An even higher percentage was found in developing countries . DLBCL is heterogeneous in morphological, immunophenotypic, cytogenetic and molecular genetic features, which is consistent with a highly variable clinical course .…”

Section: Introductionmentioning

confidence: 99%

“…Identification and classification of chromosomal aberrations of hematologic disorders is an important strategy for the diagnosis, prognosis and stratification of individualized treatment. Many kinds of structural aberrations, such as gain, deletion, translocation and other types, have been reported in DLBCL [1,[4][5][6][7][8][9][10][11]. However, few large case-control studies of DLBCL describing chromosomal aberrations are available.…”

Section: Introductionmentioning

confidence: 99%

“…An even higher percentage was found in developing countries . DLBCL is heterogeneous in morphological, immunophenotypic, cytogenetic and molecular genetic features, which is consistent with a highly variable clinical course . Cancer is a genetic disease resulting from multiple genetic and epigenetic alterations of chromosomes during the process of tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Chromosome abnormalities in diffuse large B‐cell lymphomas: analysis of 231 Chinese patients

Zhao

Fan

Lin

et al. 2012

Hematological Oncology

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Genome instability is a hallmark of cancer. Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma with high levels of chromosomal aberrations. The purpose of this study was to characterize chromosomal aberrations in Chinese DLBCL patients and to compare chromosomal abnormalities between germinal centre B-cell-like (GCB) and non-GCB subgroups. Fluorescence in situ hybridization, G-band cytogenetics and immunohistochemistry were performed in 231 cases of de novo DLBCL. We demonstrated that the rate of abnormal and complex karyotypes was 89.1% (139/156) and 92.8% (129/139), respectively. We found a total of 490 structural chromosomal aberrations, including 96 frequent and recurring structural alterations. Most importantly, we identified several rare or novel chromosomal alterations: eight gains (5, 13, 14q, 17, 19p, 20, 21p, Y), one loss (21) and three recurrent translocations [t(7;15)(q22;q22), t(3;20)(p24;q13.1), t(2;3)(q21;q25)]. Moreover, the frequent recurrent genomic imbalance between GCB and non-GCB subgroups was different. Finally, we discovered two cases of concurrent IGH-BCL6 and MYC rearrangements. The rate of abnormal karyotypes in DLBCL patients of Chinese descent was similar to that of Western countries, but some common karyotypes were different, as were the abnormal karyotypes of GCB and non-GCB subgroups. Our discovery of rare and novel abnormal karyotypes may represent unique chromosomal alterations in Chinese DLBCL patients.

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New chromosome abnormalities and lack of BCL‐6 gene rearrangements in Argentinean diffuse large B‐cell lymphomas

Abstract: These studies emphasize the value of combining conventional cytogenetics with FISH and molecular studies to allow a more accurate definition of the genomic aberrations involved in DLBCL.

Cited by 10 publications

References 57 publications

SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability

SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability

Molecular cytogenetics of IGH rearrangements in non-Hodgkin B-cell lymphoma

Chromosome abnormalities in diffuse large B‐cell lymphomas: analysis of 231 Chinese patients

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