Klebsiella pneumonia and Its Antibiotic Resistance: A Bibliometric Analysis

Abstract

The rapid development of antibiotic resistance in K. pneumonia has led to a major concern. In order to analyze the hotspots and develop trends in this field through visual the analysis, this study used CiteSpace software to summarize the available data in the literature to provide insights. A total of 9366 research articles were retrieved from the Web of Science Core Collection, and the number of published papers is increasing year by year. The country with the most articles was the USA, followed by China and India. The institution with the highest number of publications was LERU. The author with the highest number of articles was Li. The journal with the highest citation rate was Antimicrobial Agents and Chemotherapy. In addition, based on keyword coword analysis and cited literature prominence analysis by CiteSpace, the current research focus in the field was therapy, CRKP, and resistance genes. This paper provides a new quantitative visualization way for the development of the field in the recent ten years. The results show global trends that researchers can use to determine future directions.

Identification and Antimicrobial Resistance in Klebsiella spp. Isolates from Turkeys in Poland between 2019 and 2022

“…The rise in drug resistance is a global issue and a critical challenge for human and veterinary medicine [ 9 ]. In response to this threat, the WHO has launched the “One Health” initiative, which aims to combat the most pressing health issues facing the modern world, such as zoonoses, antibiotic resistance, and food safety.…”

“…This conclusion is supported by the fact that the last 10 years have brought a noted increase in research on this subject, the output within this timeframe totaling approx. 10 thousand papers [ 9 ]. As a country where Klebsiella spp.…”

Characterization and comprehensive genome analysis of novel bacteriophage, vB_Kpn_ZCKp20p, with lytic and anti-biofilm potential against clinical multidrug-resistant Klebsiella pneumoniae

“…Today, they are reconsidered for treating MDR infections owing to their high specificity and ability to replicate and coevolve with their hosts. In contrast to antibiotics, phage therapy has an activity that is limited to the site of infection, and it neither leads to dysbacteriosis nor toxicity to eukaryotic cells ( Burrowes et al., 2011 ; Li et al., 2022 ). Additionally, some phages can disrupt bacterial biofilms, for example, through the production of tail-associated depolymerases, which degrade the polysaccharides of the bacterial biofilm to reach and infect the bacterial cell.…”

Antimicrobial resistance in Klebsiella pneumoniae: identification of bacterial DNA adenine methyltransferase as a novel drug target from hypothetical proteins using subtractive genomics

“…Current antibi-Antimicrobial resistance in Klebsiella pneumoniae: identification of bacterial DNA adenine methyltransferase as a novel drug target from hypothetical proteins using subtractive genomics otics are unable to effectively combat MDR pathogens, which can acquire mobile genetic traits that make them resistant to antibiotics [4]. Carbapenems and colistin are among the most potent antibiotics, but some bacteria, such as K. pneumoniae carbapenemase-producing strains have developed resistance to them [5,6].…”

“…Current antibiotics are unable to effectively combat MDR pathogens, which can acquire mobile genetic traits that make them resistant to antibiotics [ 4 ]. Carbapenems and colistin are among the most potent antibiotics, but some bacteria, such as K. pneumoniae carbapenemase-producing strains have developed resistance to them [ 5 , 6 ].…”