Klatskin's cholangiocarcinoma presenting with the sign of Leser-Trelat

Morgenthau, Ari; Almudaires, A

doi:10.1136/bcr-2019-232507

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The most reported cancers associated with TLS occur in the gastrointestinal tract [2][3][4][5]11,12,[15][16][17][18][19] , such as adenocarcinoma of the stomach, colon and rectum. 7,15,16,23 , being more common in the stomach 15,19 . Lymphoproliferative disorders are the second most common type.…”

Section: Discussionmentioning

confidence: 99%

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leles¹,

Capop²,

Crispim³

2021

JHS

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Leser-Trélat sign (TLS) is a rare paraneoplastic syndrome characterized by the sudden onset of multiple seborrheic keratoses (QS), indicating an underlying malignancy. The cancers most associated with TLS occur in the gastrointestinal tract and, as they are more common in elderly people, some authors question its legitimacy as a predictor of malignancy. So, this study aimed to compile all case reports published in the last ten years, to analyze their common characteristics, such as the sex and age of the people affected, as well as the main associated malignancies, the evolution of skin lesions and its relationship with the onset of cancer. A bibliographic search was carried out in the databases: Medical Literature Analysis and Retrieval System Online (Medline) via PubMed, Scientific Electronic Library Online (SciELO) and Latin American and Caribbean Literature in Health Sciences (LILACS), using the term: Leser-Trelat. Based on the selection criteria, 13 articles were included in this study and it was found that the disease is more common in the elderly, with no sex predilection. The most common location of QS was on the back and chest, with sudden onset and with a higher occurrence of gastric and hepatocellular adenocarcinoma, in addition to cutaneous T lymphoma. Despite the need for more studies to improve the understanding of the disease, it is concluded that TLS must indeed be considered a paraneoplastic syndrome and, therefore, an omen for screening for hidden malignancies.

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Section: Discussionmentioning

confidence: 99%

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leles¹,

Capop²,

Crispim³

2021

JHS

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“…It is mostly associated with GI adenocarcinoma and rarely with CCA[ 50 ]. It clinically presents as a 1-week history of worsening jaundice, pale stools, and recent onset abdominal pain as evident by the study of Morgenthau[ 51 ]. The pathophysiology behind this sign is a sudden increase in cytokines and various growth factors like epidermal growth factor-alpha resulting in hyperpigmentation of the skin[ 52 ].…”

Section: Paraneoplastic Syndromesmentioning

confidence: 99%

Paraneoplastic syndromes in cholangiocarcinoma

Rahman

Sana

Tahir

et al. 2020

WJH

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Paraneoplastic syndromes are the symptoms or signs which result from damage to tissues that are distant from the site of malignancy, due to complex interactions between the body’s immune system and malignant neoplasm. Cholangiocarcinoma (CCA) is an aggressive epithelial malignancy of hepatobiliary tree and it is found to be associated with various paraneoplastic syndromes. These syndromes can present as dermatological, neurological, renal, hematological, or multi-systemic manifestations. Clinical suspicion and timely recognition of these syndromes can lead to early diagnosis of covert malignancies like CCA. The management plan remains the removal of the underlying cause which in this case is CCA.

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Klatskin's cholangiocarcinoma presenting with the sign of Leser-Trelat

Cited by 2 publications

References 7 publications

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Paraneoplastic syndromes in cholangiocarcinoma

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