Paraneoplastic syndromes in cholangiocarcinoma

Rahman, Sohanur; Sana, Muhammad Khawar; Tahir, Zabreen; Ali, Aamir; Shah, Pir Ahmad

doi:10.4254/wjh.v12.i11.897

Cited by 10 publications

(10 citation statements)

References 84 publications

(30 reference statements)

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“…Paraneoplastic syndrome in cholangiocarcinoma is a very rare condition with only a few case reports worldwide. Previous cases had shown predisposing factors that led to paraneoplastic syndrome in cholangiocarcinoma 2 . In this case, DM was thought to be the possible cause of paraneoplastic syndrome.…”

Section: Discussionmentioning

confidence: 73%

“…Previous cases had shown predisposing factors that led to paraneoplastic syndrome in cholangiocarcinoma. 2 In this case, DM was thought to be the possible cause of paraneoplastic syndrome. DM is an autoimmune inflammatory myopathy, characterized by proximal muscle weakness with characteristic skin manifestations, such as heliotrope rash, Gottron papules and the V-neck and shawl signs.…”

Section: Discussionmentioning

confidence: 90%

“…However, Rahman et al concluded that cholangiocarcinoma can be associated with various paraneoplastic syndromes involving multiple organ systems, including dermatological, neurological, renal and haematological manifestations. 2 Here, we report the first case of cholangiocarcinoma with paraneoplastic syndrome consisting of acute renal failure from…”

mentioning

confidence: 93%

“…Paraneoplastic syndrome is very rare in cholangiocarcinoma. However, Rahman et al concluded that cholangiocarcinoma can be associated with various paraneoplastic syndromes involving multiple organ systems, including dermatological, neurological, renal and haematological manifestations 2 …”

Section: Introductionmentioning

confidence: 99%

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A rare case of cholangiocarcinoma presenting with paraneoplastic syndrome

et al. 2021

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Cholangiocarcinoma is an aggressive malignancy of the bile ducts.It has a poor prognosis because of the poor early detection rate and limited treatment options. Surgery is usually the treatment of choice; however, it is limited to patients with early-stage disease. Therefore, it is important to understand and identify the symptoms of paraneoplastic syndromes in order to detect occult malignancies early, when they are still at a highly treatable stage. Effective treatment can then be offered to improve both oncologic outcomes and quality of life, thus minimizing morbidity and mortality. 1 Paraneoplastic syndromes are a group of rare syndromes that arise from immune cross-reactivity between malignant and normal tissues and result in tissue damage distant from the location of the malignancy. Paraneoplastic syndrome is very rare in cholangiocarcinoma. However, Rahman et al concluded that cholangiocarcinoma can be associated with various paraneoplastic syndromes involving multiple organ systems, including dermatological, neurological, renal and haematological manifestations. 2 Here, we report the first case of cholangiocarcinoma with paraneoplastic syndrome consisting of acute renal failure from

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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A rare case of cholangiocarcinoma presenting with paraneoplastic syndrome

et al. 2021

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“…Paraneoplastic neurological syndrome (PNS) refers to a syndrome of "distant" nervous system damage caused by tumors[ 1 ], the incidence of PNS was 1/100000 person-years, and the prevalence was 4/100000 or 1 PNS in every 334 cancers[ 2 ]. The current academic consensus is to classify paraneoplastic cerebellar degeneration (PCD) as a "classic" PNS.…”

Section: Introductionmentioning

confidence: 99%

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Lou

Zhang

et al. 2021

WJCC

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BACKGROUND Paraneoplastic cerebellar degeneration (PCD), which is rare in clinical practice, is closely related to autoimmunity. Cases positive for anti-Yo antibodies (anti-Purkinje cytoplasmic antibody 1) are the main subtype of PCD. PCD is subacute cerebellar degeneration, and while it progresses over weeks to months, its resultant deficits last much longer. Cancer patients with anti-Yo antibody-positive PCD are very rare. Most of them are breast cancer or ovarian cancer patients but also occasionally lung cancer patients. CASE SUMMARY A 61-year-old woman presented with sudden vertigo, nausea, and vomiting for approximately 10 d. The patient's neurological examination showed torsion with downbeat nystagmus and ataxia of the right limb and trunk. Laboratory examination found that the patient's cerebrospinal fluid and serum were anti-Yo antibody-positive, positron emission tomography computed tomography showed an increased metabolic rate in the retroperitoneal lymph nodes, and the pathology of lymph node punctures in the retroperitoneum and neck suggested adenocarcinoma of the pancreaticobiliary duct, which strengthens the hypothesis of paraneoplastic origin. Intravenous immunoglobulin (IVIg) 0.4 g/kg/d for 5 d and methylprednisolone 160 mg for 3 d were initiated, which was reduced to 80 mg for 3 d and then to 40 mg for 7 d. After treatment with IVIg and a steroid, the patient's vertigo and ataxia alleviated. CONCLUSION The patient's vertigo and ataxia alleviated after treatment, suggesting that early immunotherapeutic intervention may have certain value in stopping neurological loss.

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Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Hussain,

Gupta,

Samuel

et al. 2023

Reviews in Medical Virology

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The immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology‐induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV‐associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.

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Paraneoplastic syndromes in cholangiocarcinoma

Cited by 10 publications

References 84 publications

A rare case of cholangiocarcinoma presenting with paraneoplastic syndrome

A rare case of cholangiocarcinoma presenting with paraneoplastic syndrome

Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

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