Kisspeptin induces ovulation in cycling Welsh pony mares

Briant, Christine; Schneider, J.; Guillaume, Daniel; Ottogalli, Monique; Duchamp, Guy; Bruneau, Bernard; Caraty, Alain

doi:10.1016/j.anireprosci.2006.04.021

Cited by 7 publications

(2 citation statements)

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“…It is perhaps therefore not surprising that providing evidence for a role of kisspeptin in the LH surge has proven more challenging. A single IV injection of a large dose of kisspeptin (10 mg) did advance ovulation in mares with large ovarian follicles (Briant et al 2006). Lower doses of kisspeptin, however, whether as bolus injections or continuous infusions, up to 9 days in length and across a range of doses, all increased circulating LH concentrations, but failed to induce an LH surge (Magee et al 2009, Decourt et al 2014, McGrath et al 2016, whether in cycling mares, anoestrous mares or those in vernal transition.…”

Section: Kisspeptin Regulation Of the Lh Surge And Ovulationmentioning

confidence: 92%

Kisspeptin and the regulation of the reproductive axis in domestic animals

Scott

Rose

Gunn

et al. 2019

Journal of Endocrinology

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The control of reproductive processes involves the integration of a number of factors from the internal and external environment, with the final output signal of these processes being the pulsatile secretion of gonadotrophin-releasing hormone (GnRH) from the hypothalamus. These factors include the feedback actions of sex steroids, feed intake and nutritional status, season/photoperiod, pheromones, age and stress. Understanding these factors and how they influence GnRH secretion and hence reproduction is important for the management of farm animals. There is evidence that the RF-amide neuropeptide, kisspeptin, may be involved in relaying the effects of these factors to the GnRH neurons. This paper will review the evidence from the common domestic animals (sheep, goats, cattle, horses and pigs), that kisspeptin neurons are (i) regulated by the factors listed above, (ii) contact GnRH neurons and (iii) involved in the regulation of GnRH/gonadotrophin secretion.

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Section: Kisspeptin Regulation Of the Lh Surge And Ovulationmentioning

confidence: 92%

Kisspeptin and the regulation of the reproductive axis in domestic animals

Scott

Rose

Gunn

et al. 2019

Journal of Endocrinology

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“…Additionally, the pre-ovulatory surge induced by estrogen is inhibited by anti-Kp antibodies, suggesting the involvement of Kp in follicular rupture and ovulation [51] . This local action of Kp in controlling ovulation is further supported by its stimulatory effect on ovulation in ewes and mares [44,81] . The importance of Kp in both female puberty and the preovulatory gonadotrophin surge has been highlighted by the use of potent Kp antagonists [16,17] .…”

Section: Modulation Of the Kisspeptin System To Induce Ovulationmentioning

confidence: 76%

Kisspeptin: Bridging physiology and clinical application in HPG axis regulation

2024

Int. J. Adv. Biochem. Res.

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Kisspeptin (Kp), a neuropeptide primarily produced by neuronal clusters within discrete hypothalamic nuclei from the KISS1 gene, serves as a critical initiator of puberty and regulator of ovulation in sexually mature females through central control of the hypothalamic-pituitary-gonadal (HPG) axis. Its interaction with the G protein-coupled receptor (GPR) 54 is indispensable for activating the HPG axis. Although extensively studied in various animal models including rodents, primates, and livestock such as sheep and cattle, the physiological characterization of the KISS1R/GPR54 system remains ongoing. Evidence suggests that KISS-1 neurons occupy a central role in the regulation of the gonadotropinreleasing hormone (GnRH) system. Beyond reproduction, Kp expression influences non-reproductive functions such as lactation, stress response, nutrition, cancer, and metabolism. The development of agonists and antagonists targeting KISS1R/GPR54 holds promise for therapeutic advancements. This paper provides a comprehensive review of Kp, its physiological effects, and the responses to its analogs on reproductive functions in animals, highlighting its importance for therapeutic and diagnostic interventions in animal reproductive diseases and infertility.

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