King’s Score may be More Effective in the Determination of Severe Fibrosis in Chronic Hepatitis B Infections

Karacaer, Zehra; Avci, Özgür; Karadağ, Fatma Yılmaz

doi:10.4274/vhd.09326

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…For FIB-4, the sensitivity for the cut-off value of 1.45 was 62% and the specificity was 67%, while for the cut-off value of 0.5 for APRI, the sensitivity was 71% and the specificity was 55%. In the study, it has been reported that APRI and FIB-4 scores gave similar results with different non-invasive methods in terms of detection of significant fibrosis 16 .…”

Section: Discussionmentioning

confidence: 60%

Kronik hepatit C’li hastaların karaciğer fibrozisini göstermede APRI ve FIB-4 skorlamalarının değeri

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Demırdal

Bilir

2023

Cukurova Medical Journal

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Purpose: Infection with hepatitis C virus causes chronic liver damage, fibrosis and in later processes, cirrhosis and liver cancer. Currently, the use of biomarkers, instead of invasive procedures, is recommended to identify liver fibrosis. In this study, we aimed to evaluate the sensitivity and specificity of aspartate aminotransferase (AST) to Platelet Ratio Index (APRI) and Fibrosis-4 Index (FIB-4) scoring for detection of "significant fibrosis" in chronic hepatitis C patients. Materials and Methods: Liver biopsy results and blood test results of 50 patients, infected with chronic hepatitis C, were analyzed. APRI and FIB-4 scores were calculated. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and consistency for APRI and FIB-4 scorings were calculated using a fourfold table. The values of APRI and FIB-4, providing the best specificity and sensitivity in the diagnosis of significant fibrosis, was determined by ROC (receiver operator characteristics curve) analysis. Results: The mean fibrosis stage of 30 patients with significant fibrosis was 2.83±0.74 and the mean patient age was 56.8±13. The sensitivity of APRI ≥ 1.5 to detect significant fibrosis was 16%, the specificity was 90%, PPV was 71% and NPV was 41%. A FIB-4 score of ≥3.25 had a sensitivity of 20%, a specificity of 95%, a PPV of 85% and a NPV of 44%. Conclusion: APRI and FIB-4 have high specificity and PPV in demonstrating significant fibrosis, but have low sensitivity and NPV. The sensitivity of FIB-4 was higher compared to the APRI scoring. More research on this subject is needed, as well as revision of fibrosis scores and development of new fibrosis scores.

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Section: Discussionmentioning

confidence: 60%

Kronik hepatit C’li hastaların karaciğer fibrozisini göstermede APRI ve FIB-4 skorlamalarının değeri

Arıkan

Demırdal

Bilir

2023

Cukurova Medical Journal

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“…There are also studies showing that FIB-4 has a relatively high diagnostic value for detecting liver fibrosis in hepatitis B patients when the diagnostic threshold is greater than 2.0. It has been shown that the King score is superior to the AAR, APRI and FIB-4 scores (22). In the study of Hamidi et al, when the cut-off value of 0.661 was taken for the King score, 0.661 AUROC, 62.9% sensitivity and 57.6% specificity were obtained (23).…”

Section: Discussionmentioning

confidence: 97%

Evaluation of fibrosis with noninvasive biochemical tests in chronic viral hepatitis B

Barutçu¹

2023

Hepatology Forum

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Background and Aims:Liver biopsy is the gold standard for detecting of fibrosis but is an invasive diagnostic method and associated with several minor and major complications.The aim of our study is to investigate the performance of non-invasive biochemical methods for predicting liver fibrosis and in making treatment decision. Material and Methods:We retrospectively evaluated data of patients who diagnosed with CHB between 2010-2020 in the xxxx University Gastroenterology Department.AAR,API,APRI,FIB-4,KING score,FIBROQ score were calculated at the time of onset diagnosis.The performance of the new Zeugma score ( 𝑮𝒍𝒐𝒃𝒖𝒍𝒊𝒏𝒆 𝒙 𝑮𝑮𝑻 𝑨𝒍𝒃𝒖𝒎𝒊𝒏 𝒙 𝑷𝒍𝒂𝒕𝒆𝒍𝒆𝒕 𝒙 𝟏𝟎𝟎) was also evaluated.We considered liver biopsy findings as gold standard.Results:We included 1051 patients (%59,9 male) with median age 36 (36±12,2) at the time of liver biopsy.The area under curve values were 0.64 for API score, 0.71 for APRI score, 0.71 for FIB-4 score, 0.72 for KİNG score, 0.59 for FIBROQ score, 0.70 for Zeugma score (p<0.05).No statistically significant difference was observed for AAR score.The KİNG, FİB-4, APRI and Zeugma scores were the best indicators for the detection of advanced fibrosis.For KİNG, FİB-4, APRI and Zeugma score, the cut-off value for the prediction of advanced fibrosis were ≥8.67, ≥0.94, ≥16.24 and ≥9.63 with a sensitivity of %50.5,%56.7,%59.6,%52.3 and specificity of %87.2,%74.9,%73.6,%78.1 respectively (p<0.05).In our study, we compared the globulin and GGT parameters with fibrosis, which we used in the Zeugma score formula.Globulin and GGT mean values were significantly higher in the fibrosis group (p <0.05).There was statistically significant correlation between fibrosis and globulin, GGT values (respectively, p<0,05; r=0,230; p<0,05; r=0,305). Conclusion:The King score, FIB-4, ARPI and Zeugma scores reliable non-invasive markers for determining liver fibrosis in patients with chronic HBV.The AAR score was not optimal for predicting hepatic fibrosis in our study.Our data suggest that Zeugma score may be a novel and alternative noninvasive test that for evaluating liver fibrosis in patients with chronic HBV.

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“…While the AUC, sensitivity, specificity, PPV, and NPV were respectively 0.783, 61%, 84%, 75%, and 72% in chronic hepatitis (CHC) patients, the AUC, sensitivity, specificity, PPV, and NPV were respectively 0.770, 60%, 83%, 66%, and 76% in CHB patients (34). Karacaer et al found that the King score with cut off value of 5.76, had AUC of 0.807, sensitivity of 73%, specificity of 73%, PPV of 92.4%, and NPV of 36.3% [35]. This research found that optimum cut off value was 7.44, and the AUC, sensitivity, specificity, PPV, and NPV were 0.885, 80.6%, 87.2%, 80.6%, and 87.2%, respectively.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

SHFI: A Novel Noninvasive Predictive Model for Significant Fibrosis in Patients With Chronic Hepatitis B

et al. 2018

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King’s Score may be More Effective in the Determination of Severe Fibrosis in Chronic Hepatitis B Infections

Cited by 6 publications

References 16 publications

Kronik hepatit C’li hastaların karaciğer fibrozisini göstermede APRI ve FIB-4 skorlamalarının değeri

Kronik hepatit C’li hastaların karaciğer fibrozisini göstermede APRI ve FIB-4 skorlamalarının değeri

Evaluation of fibrosis with noninvasive biochemical tests in chronic viral hepatitis B

SHFI: A Novel Noninvasive Predictive Model for Significant Fibrosis in Patients With Chronic Hepatitis B

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