SHFI: A Novel Noninvasive Predictive Model for Significant Fibrosis in Patients With Chronic Hepatitis B

Arslan, Fatma Demet; Karakoyun, İnanç; Tatar, Bengü; Pala, Emel Ebru; Ulasoglu, Celal; Duman, Can; Akar, Harun; Köse, Şükran; Başok, Banu İşbilen

doi:10.5812/hepatmon.63310

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…For this purpose, several antioxidants and hepatoprotective agents have been reported to significantly increase liver fibrosis in rodent models (vitamin E, glutathione, N-acetylcysteine, S-adenosyl-methionine, resveratrol, curcumin, herbal supplements, inhibitors of NADPH oxidase isoforms and many others) [66,67]. Several non-invasive tests have been made available for the assessment of liver fibrosis, such as the aspartate transaminase to platelet ratio index, enhanced liver fibrosis, FIB-4, FibroTest, Forns index and FibroScan [68][69][70].…”

Section: Biochemical Profilementioning

confidence: 99%

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Scudiero

Pero

Ranieri

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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In the last few years, a significant increase of childhood obesity incidence unequally distributed within countries and population groups has been observed, thus representing an important public health problem associated with several health and social consequences. Obese children have more than a 50% probability of becoming obese adults, and to develop pathologies typical of obese adults, that include type 2-diabetes, dyslipidemia and hypertension. Also environmental factors, such as reduced physical activity and increased sedentary activities, may also result in increased caloric intake and/or decreased caloric expenditure. In the present review, we aimed to identify and describe a specific panel of parameters in order to evaluate and characterize the childhood obesity status useful in setting up a preventive diagnostic approach directed at improving health-related behaviors and identifying predisposing risk factors. An early identification of risk factors for childhood obesity could definitely help in setting up adequate and specific clinical treatments.

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Section: Biochemical Profilementioning

confidence: 99%

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Scudiero

Pero

Ranieri

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Recently, several non-invasive tests have been made available for the assessment of liver fibrosis, such as aspartate transaminase to platelet ratio index, enhanced liver fibrosis, FIB-4, FibroTest, Forns index, FibroScan, and a significant hepatic fibrosis index [12][13][14]. Serum markers could be useful in directly and indirectly evaluating liver function and liver fibrosis [15].…”

Section: Introductionmentioning

confidence: 99%

Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review

Haghgoo

Sharafi

Alavian

2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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Chronic liver disease (CLD) is a major health problem worldwide. Non-alcoholic fatty liver disease (NAFLD), chronic hepatitis C (CHC), chronic hepatitis B (CHB), and alcoholic liver disease (ALD) are the most common etiologies of CLD. Liver biopsy is the gold standard for assessment of liver fibrosis, however, it is an invasive method. This review attempts to evaluate the usefulness of serum adiponectin, serum leptin, serum ferritin, serum transforming growth factor-β1 (TGF-β1), and serum platelet derived growth factor-BB (PDGF-BB) as non-invasive markers in the diagnosis of liver fibrosis/cirrhosis. A systematic search in MEDLINE, Web of Science, Scopus, and local databases was performed to identify articles published in English or Persian as of November 2017. Studies conducted among CLD patients, with biopsy proven fibrosis/cirrhosis, and providing sufficient details of patients' clinicopathological characteristics were included. In the 95 studies included, there were a total of 15,548 CLD patients. More than 83% of studies were carried out in Asia and Europe. The relationship between liver fibrosis/cirrhosis and serum levels of ferritin, adiponectin, leptin, TGF-β1, and PDGF-BB was assessed in 42, 33, 27, nine, and three studies, respectively. Serum levels of the markers, particularly ferritin, could successfully predict liver fibrosis/cirrhosis, however, these data might not be clinically replicated and further studies are needed.

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“…Liver fibrosis is a common response to HBV infection, which may result in potentially lethal sequelae and progression of compensated cirrhosis to hepatic decompensation and HCC. Incorrect diagnosis and monitoring of liver fibrosis can lead to progressive inflammation and fibrosis, resulting in liver cirrhosis and even HCC (4). Liver fibrosis degree can significantly affect the prognosis and treatment of chronic liver diseases.…”

Section: Introductionmentioning

confidence: 99%

Hepatic Arterial Blood Flow Index Is Associated with the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B Virus Infection

Gao

Yin

et al. 2020

Hepat Mon

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Background: Liver fibrosis due to Hepatitis B Virus (HBV) infection is an important public health concern worldwide. An accurate assessment of liver fibrosis is crucial for the identification of susceptible patients to severe clinical conditions and selection of treatment for patients with Chronic Hepatitis B (CHB) infection. Today, the development of simple, accurate, cost-effective, and non-invasive liver fibrosis tests is essential in clinical practice. Methods: According to liver biopsy as the reference standard, we compared the efficacy of hepatic arterial blood flow index (HBI) versus liver stiffness measurement (LSM), aspartate aminotransferase-to-platelet count ratio index (APRI), and fibrosis index based on 4 factors (FIB-4) to predict various degrees of liver fibrosis among 87 patients with CHB infection. Results: Spearman’s rank correlation coefficient of HBI versus the degree of liver fibrosis, according to the METAVIR scoring system, was 0.672 (P < 0.001). The area under the receiver operating characteristic curve (AUROC) of HBI (0.884; 95% CI: 0.806 - 0.961; P = 0.000) was greater than that of LSM (0.807; 95% CI: 0.703 - 0.912; P = 0.00), APRI (0.684; 95% CI: 0.556 - 0.812; P = 0.009), and FIB-4 (0.757; 95% CI: 0.641 - 0.873; P = 0.000) for the diagnostic analysis of significant liver fibrosis (≥ F2); similar results were obtained for the prediction of other liver fibrosis stages. Conclusions: The present findings shed new light on the association of HBI with the degree of liver fibrosis in patients with CHB infection. Hepatic Arterial Perfusion Scintigraphy (HAPS) with the measurement of HBI is a promising diagnostic method of liver fibrosis stage, which can guide therapy in CHB patients, although further large-scale studies are needed.

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SHFI: A Novel Noninvasive Predictive Model for Significant Fibrosis in Patients With Chronic Hepatitis B

Abstract: Background: This study aimed at creating a new predictive model of significant fibrosis in chronic hepatitis B using direct and indirect parameters and comparing this model with other noninvasive models for its validation in clinical settings.

Cited by 3 publications

References 43 publications

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review

Hepatic Arterial Blood Flow Index Is Associated with the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B Virus Infection

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