Kinetics of the disappearance of gelatin protected radiogold colloids from the blood stream

Cohen, Yehudi A.; Ingrand, Jacques; Caro, R.A.

doi:10.1016/0020-708x(68)90058-6

Cited by 13 publications

(1 citation statement)

References 5 publications

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“…Phagocytotic particle elimination of various colloids (including "solid" microspheres made of albumin, latex, or gelatin) by resident and circulating macrophages (Kupffer cells in the liver, etc.) have been well documented [23][24][25][26][27] and correlated to particle size and opsonin recognition. 23,25,27 It is not surprising that the latex microsphere group of animals, receiving a relatively inert and uniform particle size of 3.99 µm formulation with similar particle concentration to FS069, would show some WBC changes but not complete identity with the WBC changes seen in the FS069 group.…”

Section: Discussionmentioning

confidence: 99%

Lack of bioeffects of ultrasound energy after intravenous administration of FS069 (Optison) in the anesthetized rabbit.

Killam

Greener

McFerran

et al. 1998

Journal of Ultrasound in Medicine

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The current study was designed to provide a sensitive in vivo model to maximize the potential bioeffects (measured by hemolysis) of B-mode ultrasound energy in combination with FS069 (Optison). B-mode ultrasound energy was delivered to anesthetized male New Zealand white rabbits with a phased array 5 MHz transducer on a Hewlett-Packard Sonos 1500 ultrasonograph, with transmit level set to maximum (40 dB, approx 135 W/cm2). FS069 (Optison), latex particles in human albumin, or human albumin alone (vehicle) was infused via an ear vein at 0.6 mL/kg. No statistically significant changes were noted in serum free hemoglobin or lactate dehydrogenase either over time or between groups.

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